I. Intangiriro
Fosifolipide ni ibintu by'ingenzi bigize ingirabuzimafatizo kandi bigira uruhare runini mu gukomeza ubusugire n'imikorere y'utugingo ngengabuzima. Bakora lipide bilayeri ikikije kandi ikarinda neuron nizindi selile zo mu bwonko, bikagira uruhare mumikorere rusange ya sisitemu yo hagati. Byongeye kandi, fosifolipide igira uruhare muburyo butandukanye bwerekana inzira hamwe na neurotransmission inzira ikomeye mumikorere yubwonko.
Ubuzima bwubwonko nibikorwa byubwenge nibyingenzi mubuzima bwiza muri rusange nubuzima bwiza. Inzira zo mumutwe nko kwibuka, kwitondera, gukemura ibibazo, no gufata ibyemezo nibyingenzi mumikorere ya buri munsi kandi biterwa nubuzima nimikorere myiza yubwonko. Uko abantu basaza, kubungabunga imikorere yubwenge bigenda birushaho kuba ingirakamaro, bigatuma ubushakashatsi bwibintu bigira ingaruka kumagara yubwonko byingenzi mugukemura ikibazo cyo kugabanuka kwubwenge hamwe nindwara zubwenge nko guta umutwe.
Intego yubu bushakashatsi ni ugushakisha no gusesengura ingaruka za fosifolipide ku buzima bwubwonko no mumikorere yubwenge. Mugukora ubushakashatsi ku ruhare rwa fosifolipide mukubungabunga ubuzima bwubwonko no gushyigikira inzira zubwenge, ubu bushakashatsi bugamije gutanga ibisobanuro byimbitse kubyerekeye isano iri hagati ya fosifolipide nibikorwa byubwonko. Byongeye kandi, ubushakashatsi buzasuzuma ingaruka zishobora guterwa no kuvura bigamije kubungabunga no kuzamura ubuzima bwubwonko nibikorwa byubwenge.
II. Gusobanukirwa Fosifolipide
A. Ibisobanuro bya fosifolipide:
Fosifolipideni urwego rwa lipide igizwe ningingo nyamukuru yibice byose bigize selile, harimo nubwonko. Zigizwe na molekile ya glycerol, acide ebyiri zamavuta, itsinda rya fosifate, hamwe nitsinda ryumutwe wa polar. Fosifolipide irangwa na kamere ya amphifilike, bivuze ko ifite hydrophilique (ikurura amazi) hamwe na hydrophobique (yanga amazi). Uyu mutungo utuma fosifolipide ikora lipide bilayers ikora nkimiterere yimiterere ya selile, itanga inzitizi hagati yimbere yimbere yimbere nibidukikije.
B. Ubwoko bwa fosifolipide iboneka mu bwonko:
Ubwonko burimo ubwoko butandukanye bwa fosifolipide, hamwe nibinyabuzima byinshifosifatique, fosifatidylethanolamine,fosifatique, na sphingomyelin. Iyi fosifolipide igira uruhare mu miterere yihariye n'imikorere ya selile y'ubwonko. Kurugero, phosphatidylcholine nikintu cyingenzi cyimyanya myakura ya selile, mugihe phosphatidylserine igira uruhare mugukwirakwiza ibimenyetso no kurekura neurotransmitter. Sphingomyelin, ikindi kintu cyingenzi cya fosifolipide kiboneka mu bwonko bwubwonko, kigira uruhare mukubungabunga ubusugire bwimiti ya myelin ikingira kandi ikarinda fibre nervice.
C. Imiterere n'imikorere ya fosifolipide:
Imiterere ya fosifolipide igizwe na hydrophilique fosifate umutwe wumutwe ufatanye na molekile ya glycerol hamwe nimirizo ibiri ya hydrophobique fatty acide. Iyi miterere ya amphifilike ituma fosifolipide ikora lipide bilayers, imitwe ya hydrophilique ireba hanze naho umurizo wa hydrophobi ureba imbere. Iyi gahunda ya fosifolipide itanga urufatiro rwamazi ya mozayike ya selile ya selile, bigafasha guhitamo neza bikenewe mumikorere ya selile. Mu mikorere, fosifolipide igira uruhare runini mukubungabunga ubusugire nimikorere yibice byubwonko. Bagira uruhare mu gutuza no gutembera kwa selile, byorohereza ubwikorezi bwa molekile hejuru ya membrane, kandi bakagira uruhare mukumenyekanisha no gutumanaho. Byongeye kandi, ubwoko bwihariye bwa fosifolipide, nka fosifatiqueylserine, byajyanye nibikorwa byubwenge hamwe nibikorwa byo kwibuka, byerekana akamaro kabo mubuzima bwubwonko nibikorwa byubwenge.
III. Ingaruka za Fosifolipide ku buzima bwubwonko
A. Kubungabunga imiterere y'utugingo ngengabuzima:
Fosifolipide igira uruhare runini mugukomeza uburinganire bwimiterere ya selile yubwonko. Nkibice byingenzi bigize selile, fosifolipide itanga urwego rwibanze rwubwubatsi n'imikorere ya neuron nizindi selile zubwonko. Fosifolipide bilayeri ikora inzitizi yoroheje kandi ifite imbaraga itandukanya ibidukikije byimbere byingirangingo zubwonko nibidukikije, bigenga kwinjira no gusohoka kwa molekile na ion. Ubu busugire bwimiterere ningirakamaro kumikorere myiza ya selile yubwonko, kuko butuma habaho kubungabunga homeostasis yo mu nda, itumanaho hagati ya selile, no kwanduza ibimenyetso byubwonko.
B. Uruhare muri neurotransmission:
Fosifolipide igira uruhare runini mugikorwa cya neurotransmission, ningirakamaro mubikorwa bitandukanye byubwenge nko kwiga, kwibuka, no kugenzura imyumvire. Itumanaho rya neural rishingiye ku kurekura, gukwirakwizwa, no kwakira neurotransmitter kuri synaps, kandi fosifolipide igira uruhare muri ibyo bikorwa. Kurugero, fosifolipide ikora nkibibanziriza synthesis ya neurotransmitter kandi igahindura ibikorwa byabashinzwe kwakira no gutwara ibintu. Fosifolipide igira kandi ingaruka ku gutembera no gutembera kwa selile, bigira ingaruka kuri exocytose na endocytose ya neurotransmitter irimo imitsi irimo no kugenzura kwanduza synaptic.
C. Kurinda impagarara za okiside:
Ubwonko bushobora kwibasirwa cyane na okiside bitewe no gukoresha ogisijeni nyinshi, aside irike nyinshi ya polyunzurure, hamwe nuburyo buke bwo kwirinda antioxydeant. Fosifolipide, nkibigize igice kinini cyubwonko bwubwonko, bigira uruhare mukurinda imbaraga za okiside ikora nkibitego hamwe nibigega bya molekile ya antioxydeant. Fosifolipide irimo antioxydeant nka vitamine E, igira uruhare runini mu kurinda ingirabuzimafatizo zo mu bwonko kwirinda lipide peroxidisation no gukomeza ubusugire bwa membrane hamwe n’amazi. Byongeye kandi, fosifolipide nayo ikora nka molekile yerekana inzira yo gusubiza ingirabuzimafatizo zirwanya imbaraga za okiside kandi zigatera ubuzima kubaho.
IV. Ingaruka za Fosifolipide kumikorere yo kumenya
A. Ibisobanuro bya fosifolipide:
Fosifolipide ni urwego rwa lipide igizwe ningingo nyamukuru yibice byose bigize selile, harimo nubwonko. Zigizwe na molekile ya glycerol, acide ebyiri zamavuta, itsinda rya fosifate, hamwe nitsinda ryumutwe wa polar. Fosifolipide irangwa na kamere ya amphifilike, bivuze ko ifite hydrophilique (ikurura amazi) hamwe na hydrophobique (yanga amazi). Uyu mutungo utuma fosifolipide ikora lipide bilayers ikora nkimiterere yimiterere ya selile, itanga inzitizi hagati yimbere yimbere yimbere nibidukikije.
B. Ubwoko bwa fosifolipide iboneka mu bwonko:
Ubwonko burimo ubwoko butandukanye bwa fosifolipide, hamwe cyane ni fosifatidylcholine, fosifatiylethanolamine, fosifatiqueylserine, na sphingomyelin. Iyi fosifolipide igira uruhare mu miterere yihariye n'imikorere ya selile y'ubwonko. Kurugero, phosphatidylcholine nikintu cyingenzi cyimyanya myakura ya selile, mugihe phosphatidylserine igira uruhare mugukwirakwiza ibimenyetso no kurekura neurotransmitter. Sphingomyelin, ikindi kintu cyingenzi cya fosifolipide kiboneka mu bwonko bwubwonko, kigira uruhare mukubungabunga ubusugire bwimiti ya myelin ikingira kandi ikarinda fibre nervice.
C. Imiterere n'imikorere ya fosifolipide:
Imiterere ya fosifolipide igizwe na hydrophilique fosifate umutwe wumutwe ufatanye na molekile ya glycerol hamwe nimirizo ibiri ya hydrophobique fatty acide. Iyi miterere ya amphifilike ituma fosifolipide ikora lipide bilayers, imitwe ya hydrophilique ireba hanze naho umurizo wa hydrophobi ureba imbere. Iyi gahunda ya fosifolipide itanga urufatiro rwamazi ya mozayike ya selile ya selile, bigafasha guhitamo neza bikenewe mumikorere ya selile. Mu mikorere, fosifolipide igira uruhare runini mukubungabunga ubusugire nimikorere yibice byubwonko. Bagira uruhare mu gutuza no gutembera kwa selile, byorohereza ubwikorezi bwa molekile hejuru ya membrane, kandi bakagira uruhare mukumenyekanisha no gutumanaho. Byongeye kandi, ubwoko bwihariye bwa fosifolipide, nka fosifatiqueylserine, byajyanye nibikorwa byubwenge hamwe nibikorwa byo kwibuka, byerekana akamaro kabo mubuzima bwubwonko nibikorwa byubwenge.
V. Ibintu bigira ingaruka kurwego rwa fosifolipide
A. Inkomoko yimirire ya fosifolipide
Fosifolipide ningingo zingenzi zimirire myiza kandi irashobora kuboneka mubiribwa bitandukanye. Inkomoko yibanze yimirire ya fosifolipide harimo umuhondo w amagi, soya, inyama zingingo, hamwe nibiryo bimwe na bimwe byo mu nyanja nka herring, makerel, na salmon. Umuhondo w'igi, cyane cyane, ukungahaye kuri fosifatidylcholine, imwe muri fosifolipide nyinshi mu bwonko kandi ibanziriza neurotransmitter acetylcholine, ifite akamaro kanini mu kwibuka no mu mikorere. Byongeye kandi, soya nisoko yingenzi ya fosifatidylserine, indi fosifolipide yingenzi ifite ingaruka nziza mumikorere yubwenge. Kwemeza gufata neza amasoko yimirire birashobora kugira uruhare mukubungabunga urugero rwiza rwa fosifolipide kubuzima bwubwonko nibikorwa byubwenge.
B. Imibereho n'ibidukikije
Imibereho nibidukikije birashobora kugira ingaruka zikomeye kurwego rwa fosifolipide mumubiri. Kurugero, guhangayika karande no guhura nuburozi bwibidukikije birashobora gutuma umusaruro wiyongera wa molekile zitera umuriro zigira ingaruka kumiterere nubusugire bwibice bigize selile, harimo nubwonko. Byongeye kandi, ibintu byubuzima nko kunywa itabi, kunywa inzoga nyinshi, hamwe nimirire yuzuye amavuta ya transit hamwe namavuta yuzuye birashobora kugira ingaruka mbi kuri fosifolipide metabolism no mumikorere. Ku rundi ruhande, imyitozo ngororamubiri isanzwe hamwe nimirire ikungahaye kuri antioxydants, omega-3 fatty acide, nintungamubiri zingenzi zishobora guteza imbere fosifolipide nziza kandi igafasha ubuzima bwubwonko nibikorwa byubwenge.
C. Ibishobora kuzuzwa
Bitewe n'akamaro ka fosifolipide mu buzima bw'ubwonko n'imikorere y'ubwenge, hagenda hagaragara ubushake bwo kongera fosifolipide yo gushyigikira no kunoza urwego rwa fosifolipide. Inyongera ya fosifolipide, cyane cyane irimo fosifatidylserine na fosifatidylcholine ikomoka ku masoko nka soya lecithine na fosifolipine yo mu nyanja, byakozweho ubushakashatsi ku ngaruka zabyo zo kongera ubwenge. Igeragezwa rya Clinical ryerekanye ko inyongera ya fosifolipide ishobora kuzamura kwibuka, kwitabwaho, no gutunganya umuvuduko haba mubakuze n'abakuru. Byongeye kandi, inyongera ya fosifolipide, iyo ihujwe na acide ya omega-3 ya fatty acide, yerekanye ingaruka zifatika mugutezimbere ubwonko bwiza bwubwonko nibikorwa byubwenge.
VI. Ubushakashatsi nubushakashatsi
A. Incamake yubushakashatsi bujyanye na Fosifolipide nubuzima bwubwonko
Fosifolipide, ibyingenzi byingenzi bigize imiterere ya selile, bigira uruhare runini mubuzima bwubwonko no mumikorere yubwonko. Ubushakashatsi ku ngaruka za fosifolipide ku buzima bwubwonko bwibanze ku ruhare rwabo muri plastike ya synaptic, imikorere ya neurotransmitter, hamwe nubushobozi rusange bwo kumenya. Ubushakashatsi bwakoze ubushakashatsi ku ngaruka ziterwa na fosifolipide yimirire, nka fosifatidilcholine na fosifatiidylserine, ku mikorere yubwenge nubuzima bwubwonko haba mubyitegererezo byinyamaswa ndetse no mubantu. Byongeye kandi, ubushakashatsi bwerekanye inyungu zishobora guterwa na fosifolipide mu guteza imbere ubwenge no gushyigikira gusaza mu bwonko. Byongeye kandi, ubushakashatsi bwa neuroimaging bwatanze ibisobanuro byerekana isano iri hagati ya fosifolipide, imiterere yubwonko, hamwe no guhuza imikorere, bitanga urumuri kuburyo bushingiye ku ngaruka za fosifolipide ku buzima bwubwonko.
B. Ibisubizo by'ingenzi n'imyanzuro yavuye mu bushakashatsi
Kongera ubumenyi:Ubushakashatsi bwinshi bwerekanye ko fosifolipide yimirire, cyane cyane fosifatiqueylserine na fosifatiqueylcholine, ishobora kuzamura ibintu bitandukanye byimikorere yubwenge, harimo kwibuka, kwitondera, no kwihuta gutunganya. Mu igeragezwa ry’amavuriro ryateguwe, rihumye-rihumye, rigenzurwa na platbo, inyongera ya fosifatidylserine yasanze igamije kunoza imitekerereze n’ibimenyetso by’indwara ziterwa na hyperactivite yibana ku bana, byerekana ko hashobora kuvurwa uburyo bwo kuvura ubwenge. Mu buryo nk'ubwo, inyongera ya fosifolipide, iyo ihujwe na aside irike ya omega-3, yerekanye ingaruka zifatika mugutezimbere imikorere yubwenge kubantu bafite ubuzima bwiza mumyaka itandukanye. Ibyavuye mu bushakashatsi bishimangira ubushobozi bwa fosifolipide nkibintu byongera ubwenge.
Imiterere y'ubwonko n'imikorere: Ubushakashatsi bwa Neuroimaging bwatanze ibimenyetso byerekana isano iri hagati ya fosifolipide nuburyo bwubwonko ndetse no guhuza imikorere. Kurugero, ubushakashatsi bwa magnetiki resonance spectroscopy bwerekanye ko urugero rwa fosifolipide mubice bimwe byubwonko bifitanye isano nimikorere yubwenge no kugabanuka kwimyaka. Byongeye kandi, ubushakashatsi bwerekana amashusho ya diffusion tensor bwerekanye ingaruka za fosifolipide yibintu byera, bifite akamaro kanini mu itumanaho ryiza. Ubu bushakashatsi bwerekana ko fosifolipide igira uruhare runini mu kubungabunga ubwonko n'imikorere y'ubwonko, bityo bikagira ingaruka ku bushobozi bwo kumenya.
Ingaruka zo Gusaza Ubwonko:Ubushakashatsi kuri fosifolipide nabwo bugira ingaruka ku gusaza k'ubwonko no mu miterere ya neurodegenerative. Ubushakashatsi bwerekanye ko ihinduka ry’imiterere ya fosifolipide na metabolisme rishobora kugira uruhare mu kugabanuka kw’ubwenge hamwe n’indwara zifata ubwonko nk’indwara ya Alzheimer. Byongeye kandi, inyongera ya fosifolipide, cyane cyane yibanda kuri fosifatidylserine, yerekanye amasezerano yo gushyigikira gusaza kwubwonko bwiza ndetse no kugabanya kugabanuka kwubwenge bujyanye no gusaza. Ubu bushakashatsi bwerekana akamaro ka fosifolipide mu rwego rwo gusaza mu bwonko no guta ubwenge bijyanye n'imyaka.
VII. Amavuriro Yingirakamaro hamwe nicyerekezo kizaza
A. Ibishobora gukoreshwa mubuzima bwubwonko nibikorwa byubwenge
Ingaruka za fosifolipide kubuzima bwubwonko no mumikorere yubwenge bifite ingaruka zikomeye kubishobora gukoreshwa mubuvuzi. Gusobanukirwa uruhare rwa fosifolipide mu gushyigikira ubuzima bwubwonko byugurura inzira yubuvuzi bushya bwo kuvura hamwe ningamba zo gukumira zigamije kunoza imikorere yubwenge no kugabanya kugabanuka kwubwenge. Mubishobora gukoreshwa harimo iterambere rya fosifolipide ishingiye ku mirire, uburyo bwo kunganirana, hamwe nuburyo bwo kuvura abantu bafite ibyago byo kutamenya. Byongeye kandi, uburyo bushobora gukoreshwa bwa fosifolipide mu bikorwa byo gushyigikira ubuzima bw’ubwonko n’imikorere y’ubwenge mu baturage batandukanye b’amavuriro, barimo abantu bageze mu za bukuru, abantu barwaye indwara zifata ubwonko, ndetse n’abafite ubumuga bwo mu mutwe, bitanga amasezerano yo kuzamura umusaruro rusange w’ubwenge.
B. Ibitekerezo byubushakashatsi nibindi bigeragezo
Ubundi bushakashatsi nubushakashatsi bwamavuriro nibyingenzi kugirango dutezimbere gusobanukirwa ningaruka za fosifolipide kubuzima bwubwonko no mumikorere yubwonko no guhindura ubumenyi buriho mubikorwa byubuvuzi bwiza. Inyigisho z'ejo hazaza zigomba gusobanura uburyo bushingiye ku ngaruka ziterwa na fosifolipide ku buzima bw'ubwonko, harimo imikoranire yabo na sisitemu ya neurotransmitter, inzira zerekana ibimenyetso bya selile, hamwe nuburyo bwa plastike. Byongeye kandi, hakenewe ibigeragezo birebire by’amavuriro kugira ngo hamenyekane ingaruka ndende ziterwa na fosifolipide ku mikorere y’ubwenge, gusaza mu bwonko, ndetse n’ingaruka ziterwa na neurodegenerative. Ibitekerezo byubushakashatsi burimo kandi birimo gushakisha ingaruka zishobora guhuzwa na fosifolipide hamwe nibindi binyabuzima, nka omega-3 fatty acide, mugutezimbere ubuzima bwubwonko nibikorwa byubwenge. Ikigeretse kuri ibyo, ibizamini by’amavuriro byibanze ku baturage b’abarwayi, nk’abantu ku byiciro bitandukanye by’ubumuga bwo kutamenya, birashobora gutanga ubumenyi bwimbitse ku ikoreshwa ryihariye rya fosifolipide.
C. Ibyerekeye ubuzima rusange nuburezi
Ingaruka za fosifolipide ku buzima bwubwonko no mumikorere yubwenge bugera no kubuzima rusange nuburezi, hamwe ningaruka zishobora guterwa ningamba zo gukumira, politiki yubuzima rusange, hamwe nuburezi. Gukwirakwiza ubumenyi ku ruhare rwa fosifolipide mu buzima bw’ubwonko n’imikorere y’ubwenge birashobora kumenyesha ubukangurambaga bw’ubuzima rusange bugamije guteza imbere indyo yuzuye y’imirire ifasha gufata fosifoli ihagije. Byongeye kandi, gahunda z’uburezi zigamije abaturage batandukanye, harimo abakuze, abarezi, n’inzobere mu buvuzi, zirashobora gukangurira abantu kumenya akamaro ka fosifolipide mu gukomeza kwihanganira ubwenge no kugabanya ibyago byo kugabanuka kwubwenge. Byongeye kandi, guhuza amakuru ashingiye ku bimenyetso kuri fosifolipide muri gahunda y’uburezi y’inzobere mu buvuzi, inzobere mu mirire, n’abarezi bishobora kurushaho gusobanukirwa uruhare rw’imirire mu buzima bw’ubwenge kandi bigaha abantu ubushobozi bwo gufata ibyemezo byuzuye bijyanye n'imibereho yabo yo kumenya.
VIII. Umwanzuro
Muri ubu bushakashatsi bwakozwe ku ngaruka za fosifolipide ku buzima bwubwonko no mumikorere yubwonko, ingingo nyinshi zingenzi zagaragaye. Ubwa mbere, fosifolipide, nkibice byingenzi bigize uturemangingo, bigira uruhare runini mukubungabunga ubusugire bwimiterere nimikorere yubwonko. Icya kabiri, fosifolipide igira uruhare mumikorere yubwenge ishyigikira neurotransmission, plastike synaptic, hamwe nubuzima bwubwonko muri rusange. Byongeye kandi, fosifolipide, cyane cyane ikungahaye kuri aside irike ya polyunzure, ifitanye isano ningaruka za neuroprotective hamwe ninyungu zishobora guterwa no kumenya ubwenge. Byongeye kandi, imirire nubuzima bigira ingaruka kuri fosifolipide irashobora kugira ingaruka kubuzima bwubwonko no mumikorere yubwenge. Hanyuma, gusobanukirwa n'ingaruka za fosifolipide ku buzima bwubwonko ningirakamaro mugutezimbere ingamba zigamije guteza imbere ubwenge no kugabanya ingaruka zo kugabanuka kwubwenge.
Gusobanukirwa n'ingaruka za fosifolipide ku buzima bwubwonko no mumikorere yubwenge ningirakamaro cyane kubwimpamvu. Ubwa mbere, ubwo bwumvikane butanga ubushishozi muburyo bushingiye kumikorere yubwenge, butanga amahirwe yo gutezimbere ibikorwa bigamije gushyigikira ubuzima bwubwonko no kunoza imikorere yubwenge mubuzima bwose. Icya kabiri, uko abatuye isi basaza kandi ubwiyongere bwimyaka bugabanuka bwubwenge bugenda bwiyongera, gusobanura uruhare rwa fosifolipide mugusaza kwubwenge biba ngombwa mugutezimbere gusaza neza no kubungabunga imikorere yubwenge. Icya gatatu, impinduka zishobora kuba ziterwa na fosifolipide binyuze mu mirire no mu mibereho ishimangira akamaro ko kumenya no kwigisha bijyanye n'inkomoko n'ibyiza bya fosifolipide mu gushyigikira imikorere y'ubwenge. Byongeye kandi, gusobanukirwa n'ingaruka za fosifolipide ku buzima bwubwonko ni ngombwa mu kumenyesha ingamba z’ubuzima rusange, ibikorwa by’ubuvuzi, hamwe n’uburyo bwihariye bugamije guteza imbere ubwenge no kugabanya igabanuka ry’ubwenge.
Mu gusoza, ingaruka za fosifolipide ku buzima bwubwonko no mumikorere yubwonko ni ahantu henshi kandi hafite imbaraga zubushakashatsi bufite ingaruka zikomeye kubuzima rusange, mubikorwa byubuvuzi, no kumererwa neza kumuntu. Mugihe twunvise uruhare rwa fosifolipide mumikorere yubwenge ikomeje kugenda itera imbere, ni ngombwa kumenya ubushobozi bwibikorwa bigamije ingamba hamwe ningamba zihariye zikoresha inyungu za fosifolipide mugutezimbere ubushobozi bwubwenge mubuzima bwose. Muguhuza ubu bumenyi mubikorwa byubuzima rusange, ibikorwa byubuvuzi, nuburezi, turashobora guha imbaraga abantu guhitamo neza bifasha ubuzima bwubwonko nibikorwa byubwenge. Ubwanyuma, gutsimbataza byimazeyo ingaruka za fosifolipide kubuzima bwubwonko nimirimo yubwonko itanga amasezerano yo kuzamura umusaruro wubwenge no guteza imbere gusaza neza.
Reba:
1. Alberts, B., n'abandi. (2002). Ibinyabuzima bya molekuline by'akagari (ed. 4). New York, NY: Ubumenyi bwa Garland.
2. Vance, JE, & Vance, DE (2008). Fosifolipide biosynthesis mungirangingo. Ibinyabuzima na Biologiya selile, 86 (2), 129-145. https://doi.org/10.1139/O07-167
3. Svennerholm, L., & Vanier, MT (1973). Ikwirakwizwa rya lipide muri sisitemu yumuntu. II. Lipid igizwe n'ubwonko bw'umuntu bijyanye n'imyaka, igitsina, n'akarere ka anatomique. Ubwonko, 96 (4), 595-628. https://doi.org/10.1093/ubwonko/96.4.595
4. Agnati, LF, & Fuxe, K. (2000). Ihererekanyabubasha nkibintu byingenzi biranga amakuru muri sisitemu yo hagati. Ibishoboka bishya byo gusobanura agaciro ka B ya mashini ya Turing. Iterambere mubushakashatsi bwubwonko, 125, 3-19. https://doi.org/10.1016/S0079-6123(00)25003-X
5. Di Paolo, G., & De Camilli, P. (2006). Fosifinositide mugutunganya selile hamwe na membrane dinamike. Kamere, 443 (7112), 651-657. https://doi.org/10.1038/imiterere05185
6. Markesbery, WR, & Gukunda, MA (2007). Kwangiza lipide, proteyine, ADN, na RNA mubumuga bwubwenge buke. Ububiko bwa Neurologiya, 64 (7), 954-956. https://doi.org/10.1001/archneur.64.7.954
7. Bazinet, RP, & Layé, S. (2014). Polyunsaturated fatty acide na metabolite mumikorere yubwonko nindwara. Kamere Isubiramo Neuroscience, 15 (12), 771-785. https://doi.org/10.1038/nrn3820
8. Jäger, R., Purpura, M., Geiss, KR, Weiß, M., Baumeister, J., Amatulli, F., & Kreider, RB (2007). Ingaruka ya phosphatidylserine kumikorere ya golf. Ikinyamakuru cyumuryango mpuzamahanga wimirire yimikino, 4 (1), 23. https://doi.org/10.1186/1550-2783-4-23
9. Cansev, M. (2012). Ibyingenzi bya fatty acide n'ubwonko: Ingaruka zishoboka mubuzima. Ikinyamakuru mpuzamahanga cya Neuroscience, 116 (7), 921-945. https://doi.org/10.3109/00207454.2006.356874
10. Kidd, PM (2007). Omega-3 DHA na EPA kubijyanye no kumenya, imyitwarire, hamwe nuburyo bwiza: Ibisubizo byubuvuzi hamwe nuburyo bwimikorere-hamwe na selile membrane fosifolipide. Ubundi buryo bwo gusuzuma imiti, 12 (3), 207-227.
11. Lukiw, WJ, & Bazan, NG (2008). Acide ya Docosahexaenoic n'ubwonko busaza. Ikinyamakuru cyimirire, 138 (12), 2510-2514. https://doi.org/10.3945/jn.108.100354
12. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., & Tatsumi, Y. (2006). Ingaruka yubuyobozi bwa fosifatiqueylserine kumwibuka nibimenyetso byindwara ya hyperactivite yibitekerezo: Ikizamini cyamavuriro cyateganijwe, gihumye-gihumye, kigenzurwa na platbo. Ikinyamakuru cyimirire yabantu nimirire, 19 (2), 111-119. https://doi.org/10.1111/j.1365-277X.2006.00610.x
13. Hirayama, S., Terasawa, K., Rabeler, R., Hirayama, T., Inoue, T., & Tatsumi, Y. (2006). Ingaruka yubuyobozi bwa fosifatiqueylserine kumwibuka nibimenyetso byindwara ya hyperactivite yibitekerezo: Ikizamini cyamavuriro cyateganijwe, gihumye-gihumye, kigenzurwa na platbo. Ikinyamakuru cyimirire yabantu nimirire, 19 (2), 111-119. https://doi.org/10.1111/j.1365-277X.2006.00610.x
14. Kidd, PM (2007). Omega-3 DHA na EPA kubijyanye no kumenya, imyitwarire, hamwe nuburyo bwiza: Ibisubizo byubuvuzi hamwe nuburyo bwimikorere-hamwe na selile membrane fosifolipide. Ubundi buryo bwo gusuzuma imiti, 12 (3), 207-227.
15. Lukiw, WJ, & Bazan, NG (2008). Acide ya Docosahexaenoic n'ubwonko busaza. Ikinyamakuru cyimirire, 138 (12), 2510-2514. https://doi.org/10.3945/jn.108.100354
16. Cederholm, T., Salem, N., Palmblad, J. (2013). ω-3 Amavuta acide mukurinda kugabanuka kwubwenge kubantu. Iterambere mu mirire, 4 (6), 672-676. https://doi.org/10.3945/an.113.004556
17. Fabelo, N., Martín, V., Santpere, G., Marín, R., Torrent, L., Ferrer, I., Díaz, M. (2011). Guhindura cyane muburyo bwa lipide yibice byimbere ya cortex lipid rafts yindwara ya Parkinson nimpanuka 18. Indwara ya Parkinson. Ubuvuzi bwa molecular, 17 (9-10), 1107-1118. https://doi.org/10.2119/molmed.2011.00137
19. Kanoski, SE, na Davidson, TL (2010). Uburyo butandukanye bwo kutibuka buherekeza kubungabunga igihe gito kandi kirekire kumirire yingufu nyinshi. Ikinyamakuru cya Pimologiya y'Ikigereranyo: Inzira Zitwara Inyamaswa, 36 (2), 313-319. https://doi.org/10.1037/a0017318
Igihe cyo kohereza: Ukuboza-26-2023
