I. IRIBURIRO
Fosisholipids ni icyiciro cya Lipide ari ngombwa bigize inzara zakagari kandi zifite imiterere yihariye igizwe numutwe wa hydrophilic hamwe numurizo wa hydrophobic. Kamere ya ampite ya fosipulide irabafasha gukora Bilayers Lipid, niyo shingiro rya membranes. Fosifelipids igizwe na Glycerone Inyuma, iminyururu ibiri ya acide, hamwe n'itsinda rya fosifate, hamwe n'amatsinda atandukanye yometse kuri fosifate. Iyi miterere iha fosige ubushobozi bwo kwiteranya muri Bilayers na Vesches, ari ngombwa kubera ubunyangamugayo n'imikorere ya membranes y'ibinyabuzima.
Phossilupide ifite uruhare rukomeye mu nganda zinyuranye kubera imitungo yabo idasanzwe, harimo kuzenguruka, gusetsa, no kugira ingaruka zihamye. Mu nganda zibiribwa, fosipulide zikoreshwa nka emalifiers nindangabaga mubiryo bitunganijwe, hamwe nibikoresho by'utunguzi bitewe nubuzima bwabo. Muri kwisiga, fosmelipique ikoreshwa kubijyanye n'imiterere yabo itera imbere kandi ikumisha, no kuzamura itangwa ryibikoresho bifatika mubikorwa byuruhu nibicuruzwa byita ku ruhu. Byongeye kandi, fosipulide zifite ibyifuzo byingenzi muri farumasi, cyane cyane muri sisitemu yo gutanga ibiyobyabwenge no gushyiraho, bitewe nubushobozi bwabo bwo gusoza no gutanga ibiyobyabwenge muburyo bwihariye mumubiri.
II. Uruhare rwa FosifiliPide mu biribwa
A. exalimifiye no Gutezimbere Ibintu
Phossikored ikora nka ebyeiers zingenzi munganda zibiribwa kubera imiterere yabo ya ampilic. Ibi bibafasha gusabana n'amazi n'amavuta, bigatuma bakora ingendo zibangamira, nka Mayode, Kwambara salade, n'ibikomoka ku mata. Umuyobozi wa Hydrophilic Molekile yakundaga amazi, mugihe imirizo ya hydrophobic yanga kuri nayo, bikavamo gushiraho umurongo uhamye hagati yamavuta n'amazi. Uyu mutungo ufasha gukumira gutandukana no gukomeza ikwirakwizwa rimwe ryibikoresho mubicuruzwa.
B. Koresha mugutunganya ibiryo no gutanga umusaruro
Fosisholipide ikoreshwa mu gutunganya ibiryo ku mitungo yabo ikora, harimo n'ubushobozi bwabo bwo guhindura imiterere, kunoza ubukuru, kandi bigatanga umutekano ku bicuruzwa. Bakunze gukoreshwa mubikorwa byibicuruzwa bitetse, ibihuha, nibikomoka ku mata kugirango bongere ubuzima bwiza nubuzima bwangiza ibicuruzwa byanyuma. Byongeye kandi, fosipulide ikoreshwa nk'abakozi barwanya barwanya mu gutunganya inyama, inkoko, n'ibicuruzwa byo mu nyanja.
C. Inyungu zubuzima hamwe nibisabwa byimirire
Phossilupite igira uruhare mu mirire myiza y'ibiryo nk'abatwara ibintu byinshi by'imirire, nk'amagi, soya, n'ibikomoka ku mata. Bamenyekana ku nyungu zabo zubuzima, harimo uruhare rwabo muburyo bwa selire n'imikorere, hamwe nubushobozi bwabo bwo gushyigikira ubuzima bwubwonko nubuzima bwubwenge. Phossikore nayo yakozwe ubushakashatsi kugirango ubushobozi bwabo bwo kunoza metabolism nubuzima bwumubiri.
III. Gusaba fosipusi muri kwisiga
A. Gutanga imyanya no kugirira ingaruka mbi
Fosisholipide ikoreshwa cyane mu kwisiga no kwita ku kuntu ku giti cye ku ngaruka zinyuranye kandi zikamba. Kubera imiterere yabo ya ampilic, fosipulide zabo zirashobora gukora empesion zihamye, zituma amazi ahamye hamwe na peteroli avanga, bituma habaho amavuta no kwisiga hamwe nimiterere yoroshye, imwe. Byongeye kandi, imiterere yihariye ya fosiporo ibafasha kwigana uruhu rwa Lipid Liquint, rukubera uruhu rwose kandi rukumira igihombo cyamazi, rufite akamaro ko kubuma amazi, ariba ari byiza ko kubuma amazi ari byiza kubuma hydtion no gukumira gukama.
Fosifelipids nka lecithin yakoreshejwe nka Emulsifers na Moosterizers ibicuruzwa bitandukanye byo kwisiga no ku ruhu, harimo amavuta, amavuta, na sumorns. Ubushobozi bwabo bwo kuzamura imiterere, kumva, hamwe nibiranga ibyo bicuruzwa bituma bagira ingaruka zifatika munganda zo kwisiga.
B. Kuzamura itangwa ryibintu bifatika
Fosifelipide ifite uruhare rukomeye mu rwego rwo kwemeza itangwa ry'ibikoresho bifatika muri cosmere. Ubushobozi bwabo bwo gukora Liposomes, ihitisi igizwe na Bilayelipide ya Fosiporo, yemerera gukomeye no kurengera ibice bikora, nka vitamine, Antiyoxiden, nibindi bikoresho byingirakamaro. Aya macoma afasha kunoza umutekano, bioakwaiLalabulity, kandi agabajwe no gutanga ibi bikora bikora kuruhu, kuzamura imikorere yabo mubicuruzwa byihinga nibicuruzwa.
Byongeye kandi, sisitemu yo gutanga ya Fhosito yakoreshejwe kugirango ikemure ibibazo byo gutanga ibikoresho byamazi n'amashanyarazi, bibatera abatwara ibintu byinshi bikora ibintu byinshi byo kwisiga. Ibikorwa bya Liposomal birimo fosifipa byahawe akazi cyane mu gihe cyo gusaza, kibabaza, hamwe nibicuruzwa byo gusana uruhu, aho bishobora gutanga ibintu bifatika kubikorwa byuruhu.
C. Uruhare Mubicuruzwa byita ku Ruhu
Fosifelipide ifite uruhare runini mu bicuruzwa byita ku ruhu rw'ubwuzu n'ibicuruzwa byawe bwite, bigira uruhare mu mikorere yabo no gukora neza. Usibye guhimbanwa kwabo, kwiyoroshya, no kuzamura imitungo, fosifelipide kandi itanga inyungu nkimpu zuruhu, uburinzi, no gusana. Izi molekile zinyuranye zirashobora gufasha kunoza uburambe bwumva neza hamwe nibikorwa byo kwisiga, bigatuma abantu bakundwa mubigize uruhu.
Kwishyira hamwe kwa fosipusi mu bicuruzwa byita ku ruhu Kamere yabo yo mu mibereho yabafasha gukemura uruhu rutandukanye n'ubwitonzi, butanga inyungu zidasanzwe kandi zubuvuzi kubwumutekano.
IV. Gukoresha fosifinide muri farumasi
A. Gutanga ibiyobyabwenge no gushiraho
FosifelipIde ifite uruhare runini mu gutanga ibiyobyabwenge na farumasi bitewe na kamere yabo ya ampilic, bibemerera gukora ibiyobyabwenge bya Lipid na Vesticles bishoboye gukwirakwiza ibiyobyabwenge byombi bya hydrophobike n'ibiyobyabwenge. Uyu mutungo ushoboza fosisimu kugirango utezimbere kwikebagura, gushikama, na bioakwaiLebity yibiyobyabwenge bidakesha, bikamura ubushobozi bwabo bwo gukoresha. Sisitemu yo gutanga ibiyobyabwenge ishingiye ku biyobyabwenge irashobora kandi kurinda ibiyobyabwenge, kugenzura ibiyobyabwenge, kandi bigamije ingirabuzimafatizo cyangwa ingirabuzimafatizo runaka, bitanga umusanzu mu kuzamura ibiyobyabwenge ndetse n'ingaruka zo kugerwaho.
Ubushobozi bwa fosipubushobozi bwo gukora inyubako ziteraniye hamwe, nka liposomes na miryango, byakoreshejwe mugutezimbere ibijyanye na farumasi zitandukanye, harimo no mu kanwa, imyambarire, hamwe na dosiye. Ibikorwa bishingiye kuri Lipide, nko kuzenguruka, noNoparticles ikomeye, no kwinjiza uburyo bwo gutanga ibiyobyabwenge, akenshi binjiza fosiporo kugirango batsinde ibibazo bifitanye isano no kwishyura ibiyobyabwenge no kwinjizamo ibibazo bifitanye isano no kwishyurwa no kwinjizwa mu mvugo.
B. Sisitemu yo gutanga ibiyobyabwenge
Sisitemu yo gutanga ibiyobyabwenge Liposoman ni urugero rwiza rwukuntu POSSholipide ikoreshwa mubikorwa bya farumasi. Liposomes, igizwe na Bilayelipide ya Fositolipide, ifite ubushobozi bwo kwambara ibiyobyabwenge muri Bither yabo cyangwa Bilayers ya Lipide, itanga ibidukikije birinda no kugenzura irekurwa ry'ibiyobyabwenge. Sisitemu yo gutanga ibiyobyabwenge irashobora guhuzagurika kunoza imiti itandukanye, harimo n'abakozi ba chemithApeutic, antibiyotike, n'inkingo, byagabanije ibyiza nk'igihe kirekire, no kuzamura intego z'igice cyihariye cyangwa selile.
Ibisobanuro bya Liposomes bituma habaho modulation yubunini bwazo, kwishyuza, nuburyo bwo hejuru bwo guhitamo gupakira ibiyobyabwenge, gutuza, no gukwirakwiza tissue. Iyi mpinduka yatumye habaho iterambere ryinshi ryemewe na statusmosonal for progaramu zinyuranye, zishimangira akamaro ka fosifori zinyuranyije nikoranabuhanga ritanga ibiyobyabwenge.
C. Ibishobora gusaba mubushakashatsi bwubuvuzi no kuvura
Phossikore ifite amahirwe yo gusaba mubushakashatsi bwubuvuzi no kuvura birenze sisitemu yo gutanga ibiyobyabwenge. Ubushobozi bwabo bwo gukorana na membranes yakagari kandi bihindura inzira ya selile itanga amahirwe yo guteza imbere ingamba zo kurwara urugamba. Phossipolupid ikozweho iperereza ku bushobozi bwabo bwo kwibanda ku nzira mbi, modulate gene, no kuzamura imikorere y'abakozi bakuru, basaba imiti yadutse.
Byongeye kandi, fosipide yashanguriwe uruhare bagize mu guteza imbere gusana indwara zo gusana no kuvugurura, erekana ubushobozi bwo gukiza ibikomere, Ubwubatsi bw'amashami, n'ubuvuzi bwaka. Ubushobozi bwabo bwo kwigana muri kamere karemano kandi bakorana na sisitemu yibinyabuzima bituma fosipide afite aho asezerana avenue yo guteza imbere ubushakashatsi bwubuvuzi no kuvura.
V. INGORANE N'IMITERERE Y'ejo hazaza
A. IBIKORWA BY'UMURYANGO N'IBIBAZE
Imikoreshereze ya fosipusi mu biribwa, kwisiga, hamwe na farumasi irerekana ibintu bitandukanye bishinzwe kugenzura no guhangayikishwa n'umutekano. Mu nganda zibiribwa, fosisini zikoreshwa nka ebyersiers, stabilizers, na sisitemu yo gutanga kubikoresho bikora. Inzego zigenga ibiryo, nk'ubuyobozi bw'ibiyobyabwenge (FDA) muri Amerika ndetse n'Ubuyobozi bw'Ubuyobozi bw'ibiribwa mu Burayi (EFSA) mu Burayi, bigenzura umutekano n'imyanya y'ibiryo birimo fosisige. Isuzuma ry'umutekano ni ngombwa kugira ngo ibyo bishyuzwe ibiryo bya Fhositolipite bifite umutekano wo kunywa no kubahiriza amabwiriza yashyizweho.
Mu nganda zihirika, fosipidide zikoreshwa mu ruhu, umusatsi, imisatsi, n'ibicuruzwa byita ku giti cyabo kubitekerezo byabo byihishe, bitera inzitizi, hamwe nuruhu. Ibigo bishinzwe kugenzura, nk'ubumwe bw'ibihugu by'Uburayi n'amavuta yo kwisiga by'Amerika n'Ubuyobozi bw'ibiyobyabwenge (FDA), gukurikirana umutekano no kurangiza ibicuruzwa byo kwisiga birimo fosimelipide yo kurinda umutekano. Isuzuma ryumutekano nubushakashatsi bwuburozi bukorwa kugirango dusuzume umwirondoro wumutekano wa foschutid yibikoresho byimikorere ya fosimelipide.
Mu rwego rw'imiti, umutekano n'umutekano wa fosifatizo bikubiyemo imikoreshereze ya sisitemu yo gutanga ibiyobyabwenge, imitwe ya Liposoal, hamwe n'abavandimwe ba farumasi. Inzego zishinzwe kugenzura, nka FDA n'ibiro bishinzwe imiti y'i Burayi (EMA), suzuma umutekano, usuzume umutekano, kandi ubwiza bw'ibicuruzwa birimo fosimaside binyuze mu bikorwa byo gusuzuma. Impungenge z'umutekano zijyanye na fosislipide muri farumasi zishingiye cyane cyane ku burozi bushobora kuba uburozi, imbunogenity, no guhuza ibintu by'ibiyobyabwenge.
B. Kugenda bigenda no guhanga udushya
Gushyira mu bikorwa fosipi bikoreshwa mu biribwa, kwisiga, hamwe na farumasi hari imiti irimo guhangayikishwa no guhanga udushya. Mu nganda zibiribwa, gukoresha fosiporo nka ebyesifizi karemano nintagondwa ni ugukurura, biterwa no gukenera ikirango gisukuye hamwe nibikoresho bisanzwe. Tekinoroji yo guhanga udushya, nka nanomulsions ihagaze neza na fosisini, irasakuza yongeraho kukesha ibibazo n'ibinyabuzima bigize ibinyabuzima bikora, nko mu binyabuzima na vitamine.
Mu nganda zihirika, gukoresha fosifinide mubyerekeranye byuruhu rwahantuho uruhu ni inzira ikomeye, yibanze kuri sisitemu yo gutanga lipid ishingiye kubikorwa bifatika hamwe no gusana uruhinja. Amabwiriza akubiyemo Nanocarliprite ya FOSPHolipdid, nka liposomes hamwe na batwara ibikorwa bya lipid (NLCs), bitera inkunga ibikorwa byo kwisiga, bitanga umusanzu mubikorwa byo kurwanya anti-an, hamwe nibicuruzwa byizuba.
Mu rwego rw'umuti, imiti igaragara mu itangwa ry'ibiyobyabwenge rishingiye ku biyobyabwenge rikubiyemo imiti yihariye, imiti igenewe, hamwe na sisitemu yo gutanga ibiyobyabwenge. Abatwara bakomeye bateje imbere, barimo Hybrid Lipid-Polymer Nanoparticles na Lipid-bashinjwaga ibiyobyabwenge bitemewe, gukemuriza ibiyobyabwenge, gutuza, hamwe nintego yihariye.
C. Imbaraga zo guhuza inganda no kubona amahirwe yo kwiteza imbere
Guhinduranya kwa fosiporo byerekana amahirwe ku bufatanye bwambukiranya inganda no guteza imbere ibicuruzwa bishya mu masangano y'ibiryo, kwisiga, na farumasi. Ubufatanye bw'inganda bushobora koroshya kungurana ubumenyi ubumenyi, ikoranabuhanga, n'imikorere myiza bijyanye no gukoresha fosifiri mu nzego zitandukanye. Kurugero, ubuhanga muri sisitemu yo gutanga lipide iva mumiti ya farumasi irashobora gukoreshwa kugirango yongere igishushanyo mbonera cyibikoresho bya lipide bikora mubiryo no kwisiga.
Byongeye kandi, guhuza ibiryo, kwisiga, hamwe na farucetics biganisha ku iterambere ryibicuruzwa byinshi byinshi bikemura ubuzima, bwiza, nubwiza. Kurugero, nutraceuticals na cosmeceuticaticals inyoteza phosplipdide biragaragara nkibisubizo byubufatanye bwambukiranya inganda, bitanga ibisubizo bishya biteza imbere inyungu zubuzima imbere ninyuma. Ubu bufatanye kandi burera amahirwe yo gukora ubushakashatsi no guteza imbere intego yo gukora ubushakashatsi ku bushakashatsi n'ibitekerezo bya phoswolippipes na fosifipari mu bicuruzwa byinshi.
Vi. Umwanzuro
A. recap ya verisiyo n'akamaro ka fosipu
Fosifelipide ifite uruhare runini mu nganda zitandukanye, itanga urugero runini mu biryo, kwisiga, hamwe n'imirenge ya farumasi. Imiterere yabo yimiti yihariye, ikubiyemo uturere twa Hydrophilique ninzira za Hydrophobic, ibafasha gukora nka emalifier, stabilizers, na sisitemu yo gutanga kubikoresho bikora. Mu nganda zibiribwa, fosisini zigira uruhare mu itumanaho hamwe nimiterere y'ibiryo bitunganijwe, mugihe cyo kwisiga, zitanga imitungo mibi, itanduza, kandi iteruza ibikomoka ku bicuruzwa. Byongeye kandi, imiti yinganda zunganda za farumasi muri sisitemu yo gutanga ibiyobyabwenge, ibipimo bya liposoman, hamwe nibibyimba bya farumasi kubera ubushobozi bwabo bwo kuzamura ibinyabuzima hamwe nintego yihariye yibikorwa.
B. Ingaruka zo gukora ubushakashatsi nigihe cyunguzi
Nkuko ubushakashatsi bwikigo cya Fosiporo bukomeje gutera imbere, hari ingaruka nyinshi zubushakashatsi bwayo ejo hazaza hamwe ninganda. Ubwa mbere, ubundi bushakashatsi mumutekano, ningaruka, hamwe nibishobora hagati ya fosispiralipdide nibindi bikoresho birashobora gutanga inzira yo guteza imbere ibicuruzwa byo mu mibare yinjira mubyo abaguzi bahura nabaguzi bakeneye. Byongeye kandi, gukora ubushakashatsi kuri fosipolipide yikoranabuhanga muri Ikoranabuhanga nka Nanocarimu, na Hybrid, na Hybrid Nanoparticles bifata ibyemezo byo kuzamura ibinyabuzima bifatika mu biryo, kwisiga, na farumesi. Ubu bushakashatsi burashobora gutuma hashyirwaho ibicuruzwa bishya bitanga imikorere myiza nibikorwa byiza.
Duhereye ku nganda, akamaro ka fosiporo mu masezerano atandukanye ashimangira akamaro ko gukomeza guhanga udushya n'ubufatanye n'inzego. Hamwe no gukurura ibintu bisanzwe nibikorwa, kwishyira hamwe kwa fosipu mubiryo, kwisiga, hamwe na farumasi bereka amahirwe kumasosiyete yo guteza imbere ibicuruzwa byinshi, birambye bihuza nibyo abaguzi. Byongeye kandi, ibyifuzo bya fosipi byinganda bishobora kuba bikubiyemo ubufatanye bwambukiranya imirenge, aho ubumenyi nubuhanga, hamwe nikoranabuhanga, hamwe nikoranabuhanga rya farumasi rishobora guhanura ibintu bishya byubuzima bwimiterere.
Mu gusoza, guhinduranya kwa fosipubushobozi byayo hamwe nibiryo byayo mubiryo, kwisiga, hamwe na farumasi bituma biba bigize ibice byinshi. Ubushobozi bwabo bwo gukora ubushakashatsi nibisabwa byinganda bitanga inzira yo gukomeza gutera imbere mubihe byinshi hamwe nibintu bishya, bituma ahantu h'isoko ryisi yose kunganda zinyuranye.
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Igihe cyo kohereza: Ukuboza-27-2023
