Spermidine ikuramo ingano ni iki?

Ubumenyi Inyuma ya Spermidine

Spermidine ni polyamine isanzwe ibaho igira uruhare runini mubikorwa bya selile. Polyamine, nka spermidine, ni ingenzi mu mikurire, kwigana, no gufata neza ingirabuzimafatizo. Izi nteruro zigira uruhare runini mugutunganya autophagy, inzira umubiri usubiramo kandi ugahanagura selile zangiritse. Ubu buryo bwimbere "kubungabunga urugo" nibyingenzi mubuzima kandi ubu bifitanye isano no kugabanuka kwimyaka.

Ingaruka zo Kurwanya Gusaza:Spermidine ifitanye isano n'ingaruka zo kurwanya gusaza, kuko usanga igabanuka mu rwego rwo gusaza kandi ikaba ifitanye isano no kubaho igihe gito ndetse n'indwara nyinshi, zirimo imikorere mibi y'umubiri, imiterere y’umuriro, ibibazo bya sisitemu y'umutima cyangwa imitsi, na tumorigenez.
Imikorere yubudahangarwa:Spermidine igira uruhare runini mumikorere yumubiri, harimo gutandukanya no gufata neza selile T, selile B, na selile naturel (NK). Iragira kandi uruhare muri polarisiyasi ya macrophage yerekeza kuri anti-inflammatory phenotype, bityo igafasha kugabanya gucana.
Imikoranire na Gut Microbiota:Ibimenyetso byerekana ko microbiota yo munda ishobora guhuza intanga ngabo ziva muri polyamine cyangwa izindi zabanjirije. Iyi mikoranire hagati ya bagiteri na nyirayo irashobora kugira ingaruka kuri spermidine ya nyirarureshwa nubuzima muri rusange.
Kurinda umutima n'imitsi:Spermidine yerekanye ingaruka z'umutima, zishobora kugira uruhare mu gukumira indwara z'umutima.
Neuroprotection: Yerekanye kandi ingaruka za neuroprotective, zishobora kuba ingirakamaro mu kurwanya indwara zifata ubwonko.
Kwirinda Kanseri:Mugukangurira anticancer immunosurveillance, spermidine irashobora gufasha mukurinda kanseri.
Amabwiriza ya Metabolic: Spermidine igira uruhare muguhindura metabolike ya polyamine, ikubiyemo imikoranire hagati ya nyirayo na microbiota yayo.
Ibigeragezo bya Clinical n'umutekano:Kubera ko spermidine isanzwe iboneka mumirire yabantu, ibizamini byo kwa muganga kugirango byongere ifatwa bifatwa nkibishoboka. Hakozwe kandi ubushakashatsi bwo gusuzuma umutekano wa spermidine, ingaruka z’ubuzima, kwinjiza, metabolism, na bioprocessing.
Mu gusoza, spermidine ni molekile yibice byinshi ishobora kugira ingaruka kubuzima bwabantu, harimo kurwanya gusaza, imikorere yubudahangarwa, no kwirinda indwara zitandukanye. Uburyo bwibikorwa byabwo bikubiyemo imikoranire ya mikorobe yo mu nda, ingirabuzimafatizo, n'inzira za metabolike. Ubundi bushakashatsi hamwe nubuvuzi bwa kliniki birashoboka gushakisha ubushobozi bwayo nkumuti wo kuvura.

Umwirondoro wintungamubiri yubudage

Imigera y'ingano, igice cyimyororokere yintete zingano, ikungahaye ku ntungamubiri zidasanzwe. Ifite vitamine E nyinshi, magnesium, zinc, na fibre. Ariko, igituma mikorobe y'ingano irushaho kuba idasanzwe ni intanga ngabo. Mugihe intanga nke za spermidine ziboneka mubiribwa bitandukanye, mikorobe y'ingano itanga uburyo bworoshye, bworoshye kuboneka.

Poroteyine:Imigera y'ingano ni isoko nziza ya poroteyine, irimo aside amine umunani zose zingenzi, bigatuma iba proteine ​​yuzuye.
Fibre:Ifite fibre soluble na elegitoronike, ifasha mu igogora kandi ifasha kugenzura urugero rw'isukari mu maraso.
Vitamine E:Imigera y'ingano ni imwe mu masoko akungahaye kuri vitamine E, cyane cyane imiterere ya tocopherol, ikaba ari antioxydants ikomeye.
B Vitamine:Ni isoko ikungahaye kuri vitamine B, harimo thiamin (B1), riboflavin (B2), niacin (B3), aside pantothenike (B5), pyridoxine (B6), na folate (B9). Iyi vitamine igira uruhare runini mu gutanga ingufu no gukora amaraso atukura.
Vitamine B12:Nubwo bidakunze kuboneka mubiribwa byibimera, mikorobe yingano nimwe mumasoko make yibimera ya vitamine B12, ningirakamaro mumikorere yimitsi no kubyara ADN na RNA.
Amavuta acide:Imigera y'ingano irimo ingano nziza y'amavuta ya monounsaturated na polyunsaturated, harimo omega-3 na omega-6 fatty acide, zikenewe mubuzima bwumutima.
Amabuye y'agaciro:Nisoko yimyunyu ngugu itandukanye nka magnesium, fosifore, potasiyumu, zinc, fer, na selenium, bifite akamaro mumikorere myinshi yumubiri.
Phytosterole:Imigera y'ingano irimo phytosterole, ikaba ari ibimera bifasha kugabanya urugero rwa cholesterol.
Antioxydants:Kurenga vitamine E, mikorobe y'ingano nayo irimo izindi antioxydants zifasha kurinda selile kwangizwa na radicals yubuntu.
Carbohydrates:Itanga karubone nziza, igogorwa buhoro kandi igatanga isoko ihamye yingufu.
Imigera y'ingano irashobora gukoreshwa muburyo butandukanye, nk'inyongera mu kanyerera, kuminjagira ku binyampeke, cyangwa nk'ibigize ibicuruzwa bitetse. Bitewe n’ibinure byinshi, irashobora guhinduka iyo itabitswe neza, bityo rero ni ngombwa kuyigumya gukonjesha cyangwa gukonjeshwa kugirango ikomeze gushya nagaciro kayo.

 

Uburyo Ingano Zikuramo Spermidine ikora

Iyo spermidine imaze gukoreshwa, intanga ziva mu ngano ziva mu ngano zirinjira kandi zigatangira uruhare rwazo mu ngirabuzimafatizo. Bumwe mu buryo bwibanze ni ukuzamura imikorere ya mito-iyambere. Mitochondria, bakunze kuvugwa nka "power power" z'akagari, ishinzwe kubyara ingufu. Mugushyigikira ibikorwa bya mitochondrial, spermidine ntabwo ifasha mukubyara ingufu gusa ahubwo ifasha no kugabanya imbaraga za okiside, ikintu cyingenzi mubusaza. Dore uko ikora mumubiri:

Autophagy Induction:Bumwe mu buryo bw'ingenzi spermidine itekereza ko igira uruhare mu buzima no kuramba ni ugukangura autophagy, inzira ya selile ikubiyemo kwangirika no gutunganya ibice bigize selile byangiritse. Ubu buryo bujyanye no gukuraho ingirangingo zangiritse hamwe na poroteyine zegeranye, zishobora kwegeranya n'imyaka kandi zikagira uruhare mu ndwara zitandukanye. Mugutezimbere autophagy, spermidine irashobora gufasha kubungabunga ubuzima bwimikorere nimikorere.

Amabwiriza yo kwerekana Gene:Spermidine yerekanwe ko igira ingaruka kuri acetylation ya histone nizindi poroteyine, zishobora guhindura imvugo ya gene. Irashobora kubuza histone acetyltransferase (HATs), biganisha kuri deacetylation ya histone kandi birashobora guhindura iyandikwa rya gen zigira uruhare muri autophagy nibindi bikorwa bya selile.

Ingaruka za Epigenetike:Spermidine irashobora kandi kugira ingaruka kuri epigenome muguhindura acetylation yamateka, arizo poroteyine zikikije ADN. Ibi birashobora guhindura uburyo gen zigaragazwa, bityo, imikorere ya selile nubuzima.

Imikorere ya Mitochondrial:Spermidine yahujwe no kunoza imikorere ya mito-iyambere, ifite akamaro kanini mu gutanga ingufu mu ngirabuzimafatizo. Irashobora gushimangira umusaruro wa mitochondriya nshya no kongera ubwiza bw’ibyangiritse binyuze mu nzira yitwa mitofagy, ikaba ari ubwoko bwa autofagy yibasira mitochondriya.

Ingaruka zo kurwanya inflammatory:Spermidine yerekanye imiti igabanya ubukana, ishobora kuba ingirakamaro mu kugabanya umuriro ujyanye no gusaza n'indwara zitandukanye ziterwa n'imyaka.

Kurinda Stress ya Oxidative:Nka polyamine, spermidine irashobora gukora nka antioxydants, ikingira selile kwangirika kwatewe nubwoko bwa ogisijeni ikora (ROS), igira uruhare mu gusaza n'indwara nyinshi ziterwa n'imyaka.

Ingaruka Kubyubaka Intungamubiri na Senescence ya Cellular:Spermidine irashobora kandi kugira uruhara muburyo bwo kwiyumvisha intungamubiri, zishobora guhindura imikorere ya selile nko gukura, gukwirakwira, na metabolism. Hasabwe igitekerezo cyo guhagarika senescence ya selile, leta yo gufatwa kwingirangingo idasubirwaho ifitanye isano no gusaza n'indwara ziterwa n'imyaka.

Basabwe Gukoresha Ingano Zikuramo Spermidine

Abahanga barasaba kwinjiza spermidine mumirire ya buri munsi muke, kugenzurwa. Ingano yatanzwe kubwinyungu nziza ziratandukanye, ariko ubushakashatsi bwinshi busaba hagati ya miligarama 1 kugeza kuri 5 kumunsi. Umubare munini, cyane cyane muburyo bwinyongera, ugomba gukoreshwa mubwitonzi, kandi nibyiza kugisha inama inzobere mubuzima mbere yo gutangira ubutegetsi bushya.

Umwanzuro: Ejo hazaza heza hamwe ningano ya Germ Spermidine

Spermidine ikuramo mikorobe yerekana amahirwe ashimishije kubashaka kuzamura ubuzima bwabo muri rusange no kuramba. Ubushobozi bwayo bwo guteza imbere ingirabuzimafatizo, kongera imikorere yubwenge, no gushyigikira gahunda nziza yo gusaza ibifata nkinyongera itanga icyizere. Hamwe nubushakashatsi bukomeje, spermidine irashobora guhinduka inkingi yubuzima bwo kwirinda.