Mugihe uruhu rusaza, habaho kugabanuka kumikorere ya physiologique. Izi mpinduka ziterwa nibintu byombi (chronologique) hamwe nibidasanzwe (byiganjemo UV-biterwa). Ibimera bitanga inyungu zishoboka zo kurwanya bimwe mu bimenyetso byo gusaza. Hano, turasubiramo guhitamo ibihingwa hamwe nibimenyetso bya siyansi inyuma yibyo basaba kurwanya gusaza. Ibimera bishobora gutanga anti-inflammatory, antioxidant, moisturizing, UV-kurinda, nizindi ngaruka. Ubwinshi bwibimera byashyizwe kurutonde nkibigize ibintu byo kwisiga no kwisiga, ariko bike byatoranijwe hano. Ibi byatoranijwe hashingiwe kuboneka amakuru yubumenyi, inyungu bwite z abanditsi, hamwe n "" gukundwa "kwibintu byo kwisiga no kwisiga. Ibimera byasuzumwe hano birimo amavuta ya argan, amavuta ya cocout, crocin, feverfew, icyayi kibisi, marigold, amakomamanga, na soya.
Ijambo ryibanze: ibihingwa; kurwanya gusaza; amavuta ya argan; amavuta ya cocout; ingona; umuriro; icyayi kibisi; marigold; amakomamanga; soya
3.1. Amavuta ya Argan
3.1.1. Amateka, Imikoreshereze, n'ibisabwa
Amavuta ya Argan yanduye muri Maroc kandi akomoka mu mbuto za Argania sponosa L. Ifite imikoreshereze gakondo nko mu guteka, kuvura indwara zuruhu, no kwita ku ruhu no kumisatsi.
3.1.2. Ibigize hamwe nuburyo bukoreshwa
Amavuta ya Argan agizwe na 80% byamavuta yuzuye hamwe na 20% byuzuye amavuta acide kandi arimo polifenol, tocopherol, steroli, squalene, na alcool ya triterpene.
3.1.3. Ibimenyetso bya siyansi
Amavuta ya Argan yari asanzwe akoreshwa muri Maroc kugirango agabanye ibara ryo mu maso, ariko ishingiro ry'ubumenyi kuri iki kirego ntabwo ryigeze risobanuka. Mu bushakashatsi bwimbeba, amavuta ya argan yabujije tyrosinase na dopachrome tautomerase mumagambo ya B16 murine melanoma, bigatuma kugabanuka kwa dose biterwa na melanin. Ibi byerekana ko amavuta ya argan ashobora kuba intandaro ya melanin biosynthesis, ariko ibigeragezo byateganijwe (RTC) mubisobanuro byabantu birakenewe kugirango tumenye iyi hypothesis.
RTC ntoya y'abagore 60 nyuma yo gucura yavuze ko kurya buri munsi no / cyangwa gukoresha amavuta ya argan byagabanije gutakaza amazi ya transepidermal (TEWL), byongera ubworoherane bwuruhu, hashingiwe ku kwiyongera kwa R2 (ubwinshi bwuruhu rwuruhu), R5 . Amatsinda yatoranijwe kurya amavuta ya elayo cyangwa amavuta ya argan. Amatsinda yombi yakoresheje amavuta ya argan kumaboko ya volar gusa. Ibipimo byakuwe mu kuboko kw'iburyo n'ibumoso. Gutezimbere muri elastique byagaragaye mu matsinda yombi ku kuboko aho amavuta ya argan yakoreshwaga cyane, ariko ku kuboko aho amavuta ya argan adakoreshejwe gusa itsinda ryakoreshaga amavuta ya argan ryiyongereye cyane muri elastique [31]. Ibi byatewe nubwiyongere bwa antioxydeant mumavuta ya argan ugereranije namavuta ya elayo. Biravugwa ko ibyo bishobora guterwa na Vitamine E hamwe na aside ferulike, izwi nka antioxydants.
3.2. Amavuta ya cocout
3.2.1. Amateka, Imikoreshereze, n'ibisabwa
Amavuta ya cocout akomoka ku mbuto zumye za Cocos nucifera kandi ifite byinshi ikoreshwa, haba mu mateka ndetse no muri iki gihe. Yakoreshejwe nk'impumuro nziza, uruhu, hamwe nogukora umusatsi, no mubikoresho byinshi byo kwisiga. Mugihe amavuta ya cocout afite ibiyakomokaho byinshi, harimo aside ya cocout, acide hydrogène hydrogène, hamwe namavuta ya cocout hydrogène, tuzaganira kubushakashatsi bwakozwe bujyanye ahanini namavuta yisukari yisugi (VCO), ategurwa nta bushyuhe.
Amavuta ya cocout yakoreshejwe muguhindura uruhu rwuruhinja kandi rushobora kuba ingirakamaro mukuvura dermatite ya atopic kumiterere yacyo ndetse ningaruka zishobora gutera kuri Staphylococcus aureus nizindi mikorobe zuruhu kubarwayi ba atopi. Amavuta ya cocout yerekanwe kugabanya ubukoroni bwa S. aureus kuruhu rwabantu bakuru bafite dermatite ya atopic muri RTC-impumyi ebyiri.
3.2.2. Ibigize hamwe nuburyo bukoreshwa
Amavuta ya cocout agizwe na 90-95% yuzuye triglyceride (acide lauric, acide myristic, acide caprylic, acide capric, acide palmitike). Ibi bitandukanye namavuta menshi yimboga / imbuto, agizwe ahanini namavuta adahagije. Byashyizwe mubikorwa cyane byuzuye bya triglyceride kugirango bigabanye uruhu nkuruhu rwiza muguhindura impande zumye zumye za corneocytes no kuziba icyuho kiri hagati yazo.
3.2.3. Ibimenyetso bya siyansi
Amavuta ya cocout arashobora gutobora uruhu rwumye. Mirongo itandatu na kabiri kwijana rya acide yibinure muri VCO bifite uburebure busa naho 92% byuzuye, ibyo bigatuma gupakira cyane bivamo ingaruka zikomeye kuruta amavuta ya elayo. Triglyceride iri mu mavuta ya cocout isenywa na lipase mu bimera bisanzwe byuruhu kugeza glycerine na aside irike. Glycerine ni humectant ikomeye, ikurura amazi kumurongo wa corneal epidermis uturutse hanze ndetse no muruhu rwimbitse. Amavuta acide muri VCO afite aside irike ya linoleque, ifite akamaro kuko aside linoleque ishobora kurakaza uruhu. Amavuta ya cocout aruta amavuta yubumara mukugabanya TEWL kubarwayi barwaye dermatite ya atopic kandi ifite akamaro kandi ifite umutekano nkamavuta yubutare mukuvura xerose.
Acide ya Lauric, ibanziriza monolaurine kandi ni kimwe mu bintu by'ingenzi bigize VCO, irashobora kugira imiti igabanya ubukana, igashobora guhindura ikwirakwizwa ry'uturemangingo kandi ikagira uruhare mu ngaruka zimwe na zimwe ziterwa na virusi. VCO irimo aside irike ya ferulike na aside p-coumaric (acide fenolike zombi), kandi urugero rwinshi rwa acide fenolike ifitanye isano no kongera ubushobozi bwa antioxydeant. Acide ya fenolike ifite akamaro mukurwanya kwangirika kwa UV. Nubwo, nubwo bivugwa ko amavuta ya cocout ashobora gukora nkizuba ryizuba, mubushakashatsi bwa vitro bwerekana ko itanga ubushobozi-buke-bwo guhagarika UV.
Usibye ingaruka ziterwa na antioxydeant, imiterere yinyamanswa zerekana ko VCO ishobora kugabanya igihe cyo gukira ibikomere. Hariho urwego rwiyongereye rwa pepsin-soluble collagen (hejuru ya collagen cross-ihuza) mu bikomere bivurwa na VCO ugereranije no kugenzura. Histopathology yerekanye ubwiyongere bwa fibroblast hamwe na neovascularization muri ibyo bikomere. Ubushakashatsi bwinshi burakenewe kugirango tumenye niba ikoreshwa rya VCO rishobora kongera urugero rwa kolagene mu gusaza kwabantu.
3.3. Crocin
3.3.1. Amateka, Ikoreshwa, Ibisabwa
Crocin ni igice cyibinyabuzima kigizwe na saffron, gikomoka ku gutukwa kwumye kwa Crocus sativus L. Saffron ihingwa mu bihugu byinshi birimo Irani, Ubuhinde, n'Ubugereki, kandi yakoreshejwe mu buvuzi gakondo kugira ngo igabanye indwara zitandukanye zirimo kwiheba, gutwika , indwara y'umwijima, n'abandi benshi.
3.3.2. Ibigize hamwe nuburyo bukoreshwa
Crocin ishinzwe ibara rya saffron. Crocin iboneka no mu mbuto za Gardenia jasminoides Ellis. Yashyizwe mubikorwa nka karotenoide glycoside.
3.3.3. Ibimenyetso bya siyansi
Crocin igira ingaruka za antioxydeant, irinda squalene kwirinda UV iterwa na peroxidation, kandi ikabuza kurekura abunzi batera umuriro. Ingaruka ya antioxydeant yagaragaye mubushakashatsi bwa vitro bwerekanaga ibikorwa birwanya antioxydeant ugereranije na Vitamine C. Byongeye kandi, ingona ibuza UVA iterwa na selile membrane peroxidation kandi ikabuza imvugo y'abunzi benshi batera umuriro harimo IL-8, PGE-2, IL -6, TNF-α, IL-1α, na LTB4. Igabanya kandi imvugo ya gen-nyinshi zishingiye kuri NF-κB. Mu bushakashatsi bwakoresheje fibroblast y’umuco, crocin yagabanije ROS iterwa na UV, iteza imbere imvugo ya poroteyine yo mu bwoko bwa matrix Col-1, kandi igabanya umubare w’uturemangingo dufite fenotipike ya senescent nyuma y’imirasire ya UV. Igabanya umusaruro wa ROS kandi igabanya apoptose. Crocin yerekanwe guhagarika ERK / MAPK / NF-κB / STAT yerekana inzira muri selile ya HaCaT muri vitro. Nubwo ingona ifite ubushobozi bwo kurwanya isanzure ry'ikirere, uruganda rurakomeye. Imikoreshereze ya nanostructures lipid ikwirakwiza kubuyobozi bukuru yarakozweho ubushakashatsi hamwe nibisubizo bitanga icyizere. Kugirango umenye ingaruka za crocin muri vivo, hakenewe izindi moderi zinyamanswa hamwe nigeragezwa ryamavuriro ryateganijwe.
3.4. Feverfew
3.4.1. Amateka, Ikoreshwa, Ibisabwa
Feverfew, Tanacetum parthenium, nicyatsi kimaze igihe kinini cyakoreshejwe mubikorwa byinshi mubuvuzi bwa rubanda.
3.4.2. Ibigize hamwe nuburyo bukoreshwa
Feverfew irimo parthenolide, lactone ya sesquiterpene, ishobora kuba nyirabayazana w'ingaruka zayo zo kurwanya inflammatory, binyuze mu kubuza NF-κB. Uku kubuza NF-κB bigaragara ko bitigenga ingaruka za antioxydeant ya parthenolide. Parthenolide yerekanye kandi ingaruka zo kurwanya kanseri y'uruhu iterwa na UVB no kurwanya selile ya melanoma muri vitro. Kubwamahirwe, parthenolide irashobora kandi gutera allergie reaction, ibisebe byo munwa, hamwe na dermatite ya allergique. Kubera izo mpungenge, ubu ikuweho muri rusange mbere yuko feverfew yongerwaho ibicuruzwa byo kwisiga.
3.4.3. Ibimenyetso bya siyansi
Bitewe nibibazo bishobora guterwa no gukoresha parthenolide yibanze, bimwe mubintu byo kwisiga byubu birimo feverfew bikoresha parthenolide-depleted feverfew (PD-feverfew), ivuga ko idafite ubushobozi bwo gukangurira. PD-feverfew irashobora kongera ibikorwa bya ADogen-gusana uruhu, bishobora kugabanya kwangirika kwa ADN biterwa na UV. Mu bushakashatsi bwakozwe na vitro, PD-feverfew yongereye ingufu za hydrogène peroxide ya UV iterwa no kugabanuka kwa cytokine. Yerekanye ingaruka zikomeye za antioxydeant ugereranije, Vitamine C, kandi igabanya erythma iterwa na UV muri 12-RTC.
3.5. Icyayi kibisi
3.5.1. Amateka, Ikoreshwa, Ibisabwa
Icyayi kibisi cyakoreshejwe ku nyungu z’ubuzima mu Bushinwa mu binyejana byinshi. Bitewe ningaruka zikomeye za antioxydeant, hariho inyungu mugutezimbere ibintu bihamye, bioavailable topical formulaire.
3.5.2. Ibigize hamwe nuburyo bukoreshwa
Icyayi kibisi, kiva muri Camellia sinensis, kirimo ibinyabuzima byinshi byangiza umubiri hamwe n'ingaruka zishobora kurwanya gusaza, harimo cafeyine, vitamine, na polifenol. Polifenole nini mu cyayi kibisi ni catechine, cyane cyane gallocatechin, epigallocatechin (ECG), na epigallocatechin-3-gallate (EGCG). Epigallocatechin-3-gallate ifite antioxydeant, Photoprotective, immunomodulatory, anti-angiogenic, na anti-inflammatory. Icyayi kibisi kirimo kandi flavonol glycoside kaempferol nyinshi, yinjizwa neza muruhu nyuma yo kuyikoresha neza.
3.5.3. Ibimenyetso bya siyansi
Icyayi kibisi kigabanya umusaruro wa ROS udasanzwe muri vitro kandi wagabanije na ROS iterwa na ROS. Epigallocatechin-3-gallate (icyayi kibisi polyphenol) ibuza irekurwa rya UV iterwa na hydrogen peroxide, irwanya fosifora ya MAPK, kandi igabanya umuriro binyuze mu gukora NF-κB. Ukoresheje uruhu rwa ex vivo ruva kumugore wimyaka 31 ufite ubuzima bwiza, uruhu rwashizwemo icyayi cyera cyangwa icyatsi kibisi cyerekanaga kugumana ingirabuzimafatizo za Langerhans (selile-antigen-selile ishinzwe kwinjiza ubudahangarwa mu ruhu) nyuma yumucyo UV.
Muburyo bwimbeba, gukoresha cyane icyayi kibisi mbere yo guhura na UV byatumye erythma igabanuka, kugabanuka kwuruhu rwa leukocytes, no kugabanya ibikorwa bya myeloperoxidase. Irashobora kandi kubuza 5-α-reductase.
Ubushakashatsi bwinshi bwerekeye amasomo yabantu bwasuzumye inyungu zishobora guterwa nicyayi kibisi. Gushyira mu bikorwa icyayi cyatsi kibisi cyabujije 5-α-reductase kandi bituma igabanuka ryubunini bwa microcomedone muri acne microcomedonal acne. Mu bushakashatsi buto bw'ibyumweru bitandatu abantu batandukanijwe-mu maso, cream irimo EGCG yagabanije hypoxia-inducable factor 1 α (HIF-1α) hamwe no gukura kw'imitsi iva mu mitsi (VEGF), byerekana ubushobozi bwo kwirinda telangiectasias. Mu bushakashatsi bubiri-buhumye, icyayi kibisi, icyayi cyera, cyangwa imodoka byakoreshwaga gusa ku kibuno cyabakorerabushake 10 bazima. Uruhu rwahise rushyirwa hamwe na 2 × ntoya ya erythema (MED) ya UVR yigana izuba. Uruhu rwa biopies ruva kururu rubuga rwerekanye ko gukoresha icyayi kibisi cyangwa cyera gishobora kugabanya cyane kugabanuka kwingirangingo za Langerhans, zishingiye kuri CD1a nziza. Habayeho kandi gukumira igice cyangiza UV iterwa na okiside yangiza ADN, nkuko bigaragazwa no kugabanuka kurwego rwa 8-OHdG. Mu bushakashatsi butandukanye, abakorerabushake 90 bakuze batoranijwe mu matsinda atatu: Nta muti, icyayi kibisi, cyangwa icyayi cyera. Buri tsinda ryagabanijwemo ibice bitandukanye byimirasire ya UV. Muri vivo izuba rirengera wasangaga hafi ya SPF 1.
3.6. Marigold
3.6.1. Amateka, Ikoreshwa, Ibisabwa
Marigold, Calendula officinalis, ni igihingwa cyindabyo nziza kandi gishobora kuvurwa. Yakoreshejwe mu buvuzi bwa rubanda haba mu Burayi no muri Amerika nk'umuti w'ingenzi wo gutwika, gukomeretsa, gukata, no kurwara. Marigold yerekanye kandi ingaruka za anticancer muri murine yerekana kanseri y'uruhu itari melanoma.
3.6.2. Ibigize hamwe nuburyo bukoreshwa
Ibintu nyamukuru bigize imiti ya marigolds ni steroid, terpenoide, alcool ya triterpene yubusa kandi yemewe, acide fenolike, flavonoide, nibindi bintu. Nubwo ubushakashatsi bumwe bwerekanye ko gukoresha imiti ya marigold bishobora kugabanya ubukana nububabare bwa dermatite yimirasire kubarwayi bahabwa imirasire ya kanseri yamabere, ubundi bushakashatsi bwamavuriro bwerekanye ko butaruta iyo ugereranije no gukoresha amavuta yo mumazi yonyine.
3.6.3. Ibimenyetso bya siyansi
Marigold ifite imbaraga za antioxydeant n'ingaruka za cytotoxique ku ngirabuzimafatizo za kanseri y'abantu muri vitro y'uruhu rw'umuntu. Mu bushakashatsi butandukanye bwakozwe na vitro, cream irimo amavuta ya calendula yasuzumwe hifashishijwe UV spectrophotometric hanyuma isanga ifite spécranitifike iri hagati ya 290-320 nm; ibi byafashwe bivuze ko gukoresha iyi cream byatanze izuba ryiza. Ni ngombwa kumenya ariko ko ibyo bitari mu kizamini cya vivo cyabaze igipimo ntarengwa cya erythma mu bakorerabushake b’abantu kandi bikaba bitarasobanuka neza uburyo ibyo byasobanurwa mu bigeragezo by’amavuriro.
Muri vivo murine yerekana, marigold ikuramo yerekanye ingaruka zikomeye za antioxydeant nyuma ya UV. Mu bushakashatsi butandukanye, burimo imbeba za albino, ikoreshwa ryibanze ryamavuta ya kalendula yagabanije malondialdehyde (ikimenyetso cya stress ya okiside) mugihe yongereye urwego rwa catalase, glutathione, disero ya superoxide, na acide acorbike kuruhu.
Mu bushakashatsi bwibyumweru umunani buhumye buhumyi hamwe nibintu 21 byabantu, gukoresha amavuta ya kalendula kumatama byongereye uruhu ariko ntibyagize ingaruka zikomeye kumiterere yuruhu.
Inzitizi ishobora gukoreshwa mu gukoresha marigold mu kwisiga ni uko marigold ari impamvu izwi itera allergique yo guhura na dermatite, kimwe n'abandi bantu benshi bo mu muryango wa Compositae.
3.7. Amakomamanga
3.7.1. Amateka, Ikoreshwa, Ibisabwa
Amakomamanga, Punica granatum, afite imbaraga za antioxydeant kandi yakoreshejwe mubicuruzwa byinshi nka antioxydeant yibanze. Ibirungo byinshi birwanya antioxydeant bituma iba ibintu bishimishije muburyo bwo kwisiga.
3.7.2. Ibigize hamwe nuburyo bukoreshwa
Ibinyabuzima bikora mubinyabuzima byikomamanga ni tannine, anthocyanine, aside asorbike, niacin, potasiyumu, na alkaloide ya piperidine. Ibi bikoresho bikora mubinyabuzima birashobora gukurwa mumitobe, imbuto, igishishwa, igishishwa, umuzi, cyangwa uruti rwikomamanga. Bimwe muri ibyo bice bikekwa ko bifite antitumor, anti-inflammatory, anti-microbial, antioxidant, na Photoprotective. Byongeye kandi, amakomamanga ni isoko ikomeye ya polifenol. Acide Ellegic, igice cyikomamanga yamakomamanga, irashobora kugabanya ibara ryuruhu. Bitewe no kuba ikintu cyiza cyo kurwanya gusaza, ubushakashatsi bwinshi bwakoze ubushakashatsi ku buryo bwo kongera uruhu rwinjira muri uru ruganda kugirango rukoreshwe neza.
3.7.3. Ibimenyetso bya siyansi
Ibikomoka ku mbuto z'ikomamanga birinda fibroblast y'abantu, muri vitro, indwara ziterwa na UV; birashoboka bitewe nigabanuka ryimikorere ya NF-κB, kugabanya caspace ya prapoptotique-3, no kongera gusana ADN. Irerekana anti-uruhu-ikibyimba itera ingaruka muri vitro kandi ikabuza guhinduranya UVB iterwa na NF-κB na MAPK inzira. Gushyira mu bikorwa ingingo z'ikomamanga z'ikomamanga bigabanya COX-2 mu ruhu rwa porcine ruherutse kuvamo, bikavamo ingaruka zikomeye zo kurwanya inflammatory. Nubwo aside ellegic ikunze gutekerezwa nkigice cyingenzi cyibikomoka ku makomamanga, moderi ya murine yerekanaga ibikorwa byinshi byo kurwanya inflammatory hamwe nimbuto isanzwe yamakomamanga ugereranije na acide ellegic yonyine. Ikoreshwa ryibanze rya microemuliyoni yumusemburo wamakomamanga ukoresheje surfactant ya polysorbate (Hagati ya 80®) mugihe cyo kumara ibyumweru 12 ugabanije-mumaso ugereranije nibintu 11, byagaragaje melanine yagabanutse (kubera kubuza tyrosinase) no kugabanuka kwa erythma ugereranije no kugenzura ibinyabiziga.
3.8. Soya
3.8.1. Amateka, Ikoreshwa, Ibisabwa
Soya ni ibiryo bya poroteyine nyinshi hamwe na bioactive ibice bishobora kugira ingaruka zo gusaza. By'umwihariko, soya iba nyinshi muri isoflavone, ishobora kugira ingaruka za antikarcinogeneque n'ingaruka zisa na estrogene bitewe n'imiterere ya diphenolike. Izi ngaruka zisa na estrogene zishobora kurwanya zimwe mu ngaruka zo gucura ku gusaza kwuruhu.
3.8.2. Ibigize hamwe nuburyo bukoreshwa
Soya, ikomoka muri Glycine maxi, irimo proteyine nyinshi kandi irimo isoflavone, harimo glycitein, equol, daidzein, na genistein. Izi isoflavone, nanone bita phytoestrogène, zishobora kugira ingaruka za estrogene mu bantu.
3.8.3. Ibimenyetso bya siyansi
Soya irimo isoflavone nyinshi hamwe ninyungu zishobora kurwanya gusaza. Mu zindi ngaruka zishingiye ku binyabuzima, glycitein yerekana ingaruka za antioxydeant. Fibroblast ya Dermal ivurwa na glycitein yerekanaga kwiyongera kwingirabuzimafatizo no kwimuka, kongera synthesis yubwoko bwa kolagen I na III, kandi byagabanutse MMP-1. Mu bushakashatsi butandukanye, soya ya soya yahujwe n’umusemburo wa haematococcus (algae y’amazi meza nayo irwanya antioxydants), yagabanije MMP-1 mRNA n’imvugo ya poroteyine. Daidzein, soya isoflavone, yerekanye ingaruka zo kurwanya inkari, koroshya uruhu, ningaruka zitera uruhu. Diadzein irashobora gukora mugukora estrogene-reseptor-β muruhu, bikavamo imvugo ishimishije ya antioxydants ya endogenous no kugabanuka kwimpamvu zanduza zitera keratinocyte ikwirakwizwa no kwimuka. Soya ikomoka kuri soya isoflavonoid equol yiyongereye ya kolagen na elastine kandi igabanya MMPs mumico y'akagari.
Inyongera mubushakashatsi bwa vivo murine yerekana ko igabanuka rya UVB iterwa ningirabuzimafatizo no kugabanuka kwibyorezo bya epidermal muri selile nyuma yo gukoreshwa muburyo bwa isoflavone. Mu bushakashatsi bwakozwe ku bagore 30 nyuma yo gucura, gukoresha umunwa wa isoflavone mu mezi atandatu byatumye ubwiyongere bwa epidermal bwiyongera ndetse na kolagen ya dermal yiyongera nkuko bipimwa na biopies y’uruhu ahantu harinzwe n’izuba. Mu bushakashatsi butandukanye, soya isoflavone isukuye yabujije urupfu rwa keratinocyte iterwa na UV kandi igabanya TEWL, umubyimba wa epidermal, na erythema mu ruhu rwimbeba UV.
Icyifuzo cya kabiri-gihumye RCT y'abagore 30 bafite imyaka 45-55 ugereranije no gukoresha estrogene na genistein (soya isoflavone) n'uruhu ibyumweru 24. Nubwo itsinda rikoresha estrogene kuruhu ryagize ibisubizo byiza, ayo matsinda yombi yerekanaga ubwoko bwa I na III bwo mu bwoko bwa kolagen bwo mu maso bushingiye kuri biopies yuruhu rwuruhu rwa preauricular. Soya oligopeptides irashobora kugabanya igipimo cya erythema muruhu rwerekanwe na UVB (ukuboko) kandi bikagabanya ingirabuzimafatizo zuba hamwe na cyclobutene pyrimidine dimers muri UVB-iradiya foreskin selile ex vivo. Ikigeragezo cy’impumyi zibiri zagenzuwe n’ibyumweru 12 by’amavuriro yitabiriwe n’abakobwa 65 bafite amafoto yo mu maso atagereranywa yerekanaga ko hari iterambere ry’imiterere y’imiterere, ibibyimba, umwijima, imirongo myiza, imiterere y’uruhu, hamwe n’uruhu ugereranije n’ikinyabiziga. Hamwe na hamwe, izi ngingo zishobora gutanga ingaruka zo kurwanya gusaza, ariko hakenewe ibigeragezo bikomeye byamavuriro bikenewe kugirango bigaragaze neza inyungu zabyo.
4. Ikiganiro
Ibicuruzwa bikomoka ku bimera, harimo n’ibivugwa hano, bifite ingaruka zo kurwanya gusaza. Uburyo bukoreshwa mu kurwanya gusaza ibimera birimo imbaraga za scaringing yubusa ya antioxydants ikoreshwa cyane, kurinda izuba, kongera uruhu rwinshi, hamwe ningaruka nyinshi zitera kwiyongera kwa kolagen cyangwa kugabanuka kwa kolagen. Zimwe muri izo ngaruka zoroheje mugihe ugereranije nubuvuzi bwa farumasi, ariko ibi ntibigabanya inyungu zishobora guterwa mugihe bikoreshejwe hamwe nizindi ngamba nko kwirinda izuba, gukoresha izuba, izuba ryinshi rya buri munsi hamwe nubuvuzi bukwiye bwo kuvura indwara zuruhu zihari.
Byongeye kandi, ibihingwa bitanga ubundi buryo bukoreshwa mubinyabuzima kubarwayi bakunda gukoresha ibintu "bisanzwe" gusa kuruhu rwabo. Nubwo ibyo bikoresho biboneka muri kamere, ni ngombwa gushimangira abarwayi ko ibyo bidasobanuye ko ibyo bintu bifite ingaruka mbi zeru, mubyukuri, ibicuruzwa byinshi by’ibimera bizwi ko ari byo bishobora gutera dermatite ya allergique.
Nkuko ibicuruzwa byo kwisiga bidasaba urwego rumwe rwibimenyetso kugirango bigaragaze neza, akenshi biragoye kumenya niba ibivugwa mu ngaruka zo kurwanya gusaza ari ukuri. Benshi mu bimera byavuzwe hano, ariko, bifite ingaruka zo kurwanya gusaza, ariko harakenewe ibigeragezo bikomeye byamavuriro. Nubwo bigoye guhanura uburyo izo miti y’ibimera izagirira akamaro abarwayi n’abaguzi mu gihe kiri imbere, birashoboka cyane ko kuri benshi muri ibyo bimera, ibihimbano bibinjiza nkibigize ibikoresho bizakomeza kwerekanwa nkibicuruzwa byita ku ruhu kandi niba aribyo gumana umutekano mugari, kwemerwa kwinshi kwabaguzi, no guhendwa neza, bizakomeza kuba bimwe mubikorwa bisanzwe byo kwita ku ruhu, bitanga inyungu nkeya kubuzima bwuruhu. Ku mubare muto w’ibi bikoresho by’ibimera, ariko, ingaruka nini ku baturage muri rusange zishobora kuboneka binyuze mu gushimangira ibimenyetso by’ibikorwa byabo by’ibinyabuzima, binyuze mu bushakashatsi bw’ibinyabuzima byinjira cyane hanyuma bigashyirwa ku ntego zitanga ikizamini cyo kwipimisha kwa muganga.
Igihe cyo kohereza: Gicurasi-11-2023
