Uko uruhu rusaza, habaho igabanuka ry'imikorere y'umubiri. Izi mpinduka ziterwa n'ibintu by'imbere mu mubiri (igihe) n'ibintu byo hanze (bikunze guterwa na UV). Ibimera bitanga inyungu zishobora gukoreshwa mu kurwanya bimwe mu bimenyetso by'ubusaza. Hano, turasuzuma ibimera byatoranijwe n'ibimenyetso bya siyansi biri inyuma y'ibyo bivuga ku kurwanya gusaza. Ibimera bishobora gutanga ingaruka zirwanya ububyimbirwe, antioxidant, moisturizing, UV-protective, n'izindi ngaruka. Ibimera byinshi biri ku rutonde rw'ibintu bikoreshwa mu kwisiga no mu kwisiga bizwi cyane, ariko bike gusa ni byo bivugwa hano. Ibi byatoranijwe hashingiwe ku makuru ya siyansi ahari, inyungu z'abanditsi, n'uko "bikunzwe" n'ibicuruzwa byo kwisiga n'iby'ubwiza bigezweho. Ibimera byasuzumwe hano birimo amavuta ya argan, amavuta ya kokonati, crocin, feverfew, icyayi kibisi, marigold, pomegranate, na soya.
Amagambo ahinnye: ibimera; kurwanya gusaza; amavuta ya argan; amavuta ya kokonati; crocin; feverfew; icyayi kibisi; marigold; pomegranate; soya
3.1. Amavuta ya Argan
3.1.1. Amateka, Imikoreshereze, n'Ibirego
Amavuta ya Argan aboneka cyane muri Maroc kandi akorwa mu mbuto za Argania sponosa L. Akoreshwa mu buryo butandukanye nko mu guteka, kuvura indwara z'uruhu, no kwita ku ruhu n'umusatsi.
3.1.2. Imiterere n'uburyo bwo gukora
Amavuta ya Argan agizwe na 80% by'ibinure bitagira ibinure na 20% by'ibinure byuzuye kandi arimo polyphenols, tocopherols, sterols, squalene, na triterpene alcohol.
3.1.3. Ibimenyetso bya siyansi
Amavuta ya Argan yakunze gukoreshwa muri Maroc mu kugabanya ibara ry’isura, ariko ishingiro rya siyansi ry’iki gitekerezo ntiryari rizwi mbere. Mu bushakashatsi bwakozwe ku mbeba, amavuta ya argan yabujije tyrosinase na dopachrome tautomerase ku turemangingo twa melanoma ya B16 murine, bigatuma ingano ya melanin igabanuka bitewe n’umuti. Ibi bigaragaza ko amavuta ya argan ashobora kuba imbogamizi ikomeye ku ikorwa rya melanin, ariko hakenewe ibizamini byo kugenzura abantu ku buryo butaziguye (RTC) kugira ngo hagenzurwe iki gitekerezo.
Itsinda rito rya RTC ry’abagore 60 bamaze gucura ryagaragaje ko gukoresha amavuta ya argan buri munsi cyangwa kuyashyira mu myanya ndangagitsina bigabanya gutakaza amazi mu ruhu (TEWL), bikongera ubukana bw’uruhu, hashingiwe ku kwiyongera kwa R2 (ubukana bw’uruhu), R5 (ubukana bw’uruhu), na R7 (ubukana bw’ibinyabuzima) hamwe no kugabanuka kw’igihe cyo gukora (RRT) (igipimo gifitanye isano n’ubukana bw’uruhu). Amatsinda yakoreshejwe ku buryo butaziguye kugira ngo anywe amavuta ya elayo cyangwa amavuta ya argan. Amatsinda yombi yakoresheje amavuta ya argan ku kuboko kw’ibumoso gusa. Ibipimo byafashwe ku kuboko kw’iburyo n’ibumoso. Iterambere ry’ubukana ryagaragaye mu matsinda yombi ku kuboko aho amavuta ya argan yashyirwaga ku kuboko, ariko ku kuboko aho amavuta ya argan atashyirwaga gusa, itsinda ryakoreshaga amavuta ya argan ryagize ubukana bugaragara [31]. Ibi byatewe n’ubwiyongere bw’ibinyabutabire mu mavuta ya argan ugereranije n’amavuta ya elayo. Bikekwa ko ibi bishobora guterwa na Vitamine E na aside ferulic, izizwiho kuba antioxydants.
3.2. Amavuta ya kokonati
3.2.1. Amateka, Imikoreshereze, n'Ibirego
Amavuta ya kokonati akomoka ku mbuto zumye za Cocos nucifera kandi afite akamaro kenshi, haba mu mateka no mu gihe cya none. Yakoreshejwe nk'umuti wo guhumuriza uruhu, uruhu, no mu bikoresho byinshi byo kwisiga. Nubwo amavuta ya kokonati afite ibintu byinshi bikomokaho, harimo aside ya kokonati, aside ya kokonati ya hydrogenated, n'amavuta ya kokonati ya hydrogenated, tuzaganira ku byavuzwe mu bushakashatsi bifitanye isano cyane cyane n'amavuta ya kokonati ya virgin (VCO), ategurwa nta bushyuhe.
Amavuta ya kokonati yakoreshejwe mu gukurura uruhu rw'umwana kandi ashobora kuba ingirakamaro mu kuvura indwara ya atopic dermatitis bitewe n'ubushobozi bwayo bwo gukurura uruhu ndetse n'ingaruka zayo ku mikorobe za Staphylococcus aureus n'izindi mikorobe z'uruhu ku barwayi ba atopic. Amavuta ya kokonati yagaragaye ko agabanya S. aureus colonization ku ruhu rw'abantu bakuru bafite atopic dermatitis muri RTC ifite double-blind.
3.2.2. Imiterere n'uburyo bwo gukora
Amavuta ya kokonati agizwe na triglycerides yuzuye 90–95% (aside laurique, aside myristic, aside caprilic, aside caprique, na aside palmitic). Ibi bitandukanye n'amavuta menshi y'imboga/imbuto, agizwe cyane cyane n'ibinure bidafite amavuta menshi. Triglycerides yuzuye ikoreshwa ku mubiri ifasha uruhu kumera neza binyuze mu kugabanya impande z'imitsi yumye ya corneocytes no kuzuza icyuho kiri hagati yazo.
3.2.3. Ibimenyetso bya siyansi
Amavuta ya kokonati ashobora kuroshya uruhu rwumye rusaza. Mirongo itandatu na kabiri ku ijana bya aside irike iri muri VCO ifite uburebure bumwe kandi 92% byuzuye, bigatuma habaho gupfunyika gukomeye bigatuma habaho ingaruka nziza zo kwihisha kurusha amavuta ya elayo. Triglycerides iri mu mavuta ya kokonati igabanywa na lipase mu bimera bisanzwe by'uruhu ikajya kuri glycerin na aside irike. Glycerin ni humectant ikomeye, ikurura amazi mu gice cy'imbere cy'uruhu uhereye hanze no mu bice byimbitse by'uruhu. Aside irike iri muri VCO ifite aside linoleic nke, ibi bikaba ari ingenzi kuko aside linoleic ishobora kubabaza uruhu. Amavuta ya kokonati aruta ay'imyunyu ngugu mu kugabanya TEWL ku barwayi ba dermatitis ya atopic kandi ni meza kandi afite umutekano nk'amavuta ya myunyu ngugu mu kuvura xerosis.
Aside ya Laurike, itangira monolaurine ikaba n'igice cy'ingenzi cya VCO, ishobora kugira ubushobozi bwo kurwanya ububyimbirwe, ikabasha guhindura ikwirakwira ry'uturemangingo tw'umubiri no kuba nyirabayazana wa zimwe mu ngaruka za VCO zo kurwanya udukoko. VCO ikubiyemo aside nyinshi ya ferulic na aside p-coumaric (zombi aside phenolic), kandi urugero rwinshi rw'izi aside phenolic rufitanye isano no kwiyongera k'ubushobozi bwa antioxydant. Aside phenolic igira akamaro mu kurwanya kwangirika guterwa na UV. Nyamara, nubwo bivugwa ko amavuta ya kokonati ashobora gukora nk'umuti urinda izuba, ubushakashatsi bwakozwe muri vitro bugaragaza ko itanga ubushobozi buke bwo gukumira UV.
Uretse ingaruka zayo zo koroshya no kurwanya indwara ziterwa n’ingufu, inyamaswa zigaragaza ko VCO ishobora kugabanya igihe cyo gukira kw’ibikomere. Hari urwego rwinshi rwa pepsin-soluble collagen (collagen cross-linking) mu bikomere byavuwe na VCO ugereranije n’izindi. Histopathology yagaragaje ko fibroblast yiyongera ndetse n’imitsi mito y’amaraso muri ibi bikomere. Hakenewe ubundi bushakashatsi kugira ngo harebwe niba gukoresha VCO hejuru bishobora kongera urugero rwa collagen mu ruhu rw’umuntu rusaza.
3.3. Crocin
3.3.1. Amateka, Imikoreshereze, Ibirego
Crocin ni igice cy’ingenzi cya saffron mu miterere y’ibinyabuzima, gikomoka ku gisebe cyumye cya Crocus sativus L. Saffron ihingwa mu bihugu byinshi birimo Irani, Ubuhinde, n’Ubugereki, kandi yakoreshejwe mu buvuzi gakondo mu kugabanya indwara zitandukanye zirimo kwiheba, kubyimba, indwara z’umwijima, n’izindi nyinshi.
3.3.2. Imiterere n'uburyo bwo gukora
Crocin ni yo ituma habaho ibara rya safroni. Crocin iboneka kandi mu mbuto za Gardenia jasminoides Ellis. Ishyirwa mu cyiciro cya carotenoid glycoside.
3.3.3. Ibimenyetso bya siyansi
Crocin ifite ingaruka ku irwanya ubudahangarwa bw'umubiri, irinda squalene peroxidation iterwa na UV, kandi ikarinda irekurwa ry'ibintu bitera ubushyuhe. Ingaruka ku irwanya ubudahangarwa bw'umubiri zagaragaye mu isuzuma ryakozwe muri vitro ryagaragaje imikorere myiza ya antioxidant ugereranije na Vitamine C. Byongeye kandi, crocin ibuza peroxidation y'uturemangingo duterwa na UVA kandi ikabuza igaragara ry'ibintu byinshi bitera ubushyuhe birimo IL-8, PGE-2, IL-6, TNF-α, IL-1α, na LTB4. Inagabanya kandi igaragara ry'uturemangingo twinshi dushingiye kuri NF-κB. Mu bushakashatsi bwakozwe hakoreshejwe fibroblasts z'abantu, crocin yagabanyije ROS iterwa na UV, yateje imbere igaragara rya poroteyine ya Col-1 yo hanze y'umubiri, kandi igabanya umubare w'uturemangingo dufite imiterere y'umubiri nyuma y'imirasire ya UV. Igabanya ikorwa rya ROS kandi ikagabanya apoptosis. Crocin byagaragaye ko igabanya inzira z'ibimenyetso za ERK/MAPK/NF-κB/STAT mu turemangingo twa HaCaT muri vitro. Nubwo crocin ifite ubushobozi bwo kurwanya gusaza kw'uturemangingo, iki kinyabutabire ni ikintu kidakora neza. Gukoresha uburyo bwo gukwirakwiza ibinure mu mubiri hakoreshejwe uburyo bwa nanostructured lipids mu gutanga imiti yo mu mubiri byakoreweho ubushakashatsi, kandi ibisubizo bitanga icyizere. Kugira ngo hamenyekane ingaruka za crocin mu mubiri, hakenewe izindi ngero z’inyamaswa n’ibizamini by’ubuvuzi bya buri gihe.
3.4. Indwara y'umufunzo
3.4.1. Amateka, Imikoreshereze, Ibirego
Feverfew, Tanacetum parthenium, ni icyatsi kiramba cyakoreshejwe mu buryo butandukanye mu buvuzi gakondo.
3.4.2. Imiterere n'uburyo bwo gukora
Feverfew irimo parthenolide, sesquiterpene lactone, ishobora kuba nyirabayazana w’ingaruka zimwe na zimwe zayo zo kurwanya ububyimbirwe, binyuze mu gukumira NF-κB. Uku gukumira NF-κB bisa nkaho kudashingiye ku ngaruka za parthenolide zo kurwanya antioxidant. Parthenolide kandi yagaragaje ingaruka zo kurwanya kanseri ku kanseri y’uruhu iterwa na UVB no ku tunyangingo twa melanoma muri vitro. Ikibabaje ni uko parthenolide ishobora no gutera ubwivumbure, udusebe two mu kanwa, na dermatitis yo mu kanwa. Kubera izi mpungenge, ubu ikurwaho mbere yuko feverfew yongerwa mu bicuruzwa byo kwisiga.
3.4.3. Ibimenyetso bya siyansi
Bitewe n'ingorane zishobora guterwa no gukoresha parthenolide ku mubiri, bimwe mu bikoresho byo kwisiga birimo feverfew bikoresha parthenolide-depleted feverfew (PD-feverfew), ivuga ko nta bushobozi bwo gutuma uruhu rusa neza. PD-feverfew ishobora kongera imikorere yo gusana ADN mu ruhu, bigashobora kugabanya kwangirika kwa ADN guterwa na UV. Mu bushakashatsi bwakorewe muri vitro, PD-feverfew yagabanyije imiterere ya hydrogen peroxide iterwa na UV kandi igabanya isohoka rya cytokine itera ububyimbirwe. Yagaragaje ingaruka zikomeye zo kurwanya antioxidant kurusha Vitamine C, ndetse igabanya erythema iterwa na UV muri RTC y’abantu 12.
3.5. Icyayi cy'icyatsi kibisi
3.5.1. Amateka, Imikoreshereze, Ibirego
Icyayi cy’icyatsi kibisi kimaze ibinyejana byinshi kinyobwa mu Bushinwa kubera inyungu zacyo ku buzima. Bitewe n’ingaruka zacyo zikomeye zo kurwanya imisemburo mibi, hari abashishikajwe no guteza imbere uburyo buhamye kandi buboneka ku mubiri.
3.5.2. Imiterere n'uburyo bwo gukora
Icyayi cy’icyatsi kibisi, gikomoka kuri Camellia sinensis, gifite ibintu byinshi bifasha mu kurwanya gusaza, birimo kafeyine, vitamine, na polyphenols. Polyphenols zikomeye mu cyayi cy’icyatsi kibisi ni catechins, cyane cyane gallocatechin, epigallocatechin (ECG), na epigallocatechin-3-gallate (EGCG). Epigallocatechin-3-gallate ifite ubushobozi bwo kurwanya antioxidant, kurinda foto, gutuma umubiri udashobora kuvura indwara, kurwanya angiogenic, no kurwanya ububyimbirwe. Icyayi cy’icyatsi kibisi gifite kandi ingano nini ya flavonol glycoside kaempferol, inyurwa neza n’uruhu nyuma yo kuyikoresha ku mubiri.
3.5.3. Ibimenyetso bya siyansi
Icayi kibisi gikozwe mu cyayi gigabanya umusaruro wa ROS mu ngirabuzimafatizo kandi cyagabanyije ubwiyongere bw’indwara ya ROS. Epigallocatechin-3-gallate (polyphenol y’icyayi kibisi) ibuza irekurwa rya hydrogen peroxide iterwa na UV, ikagabanya phosphorylation ya MAPK, kandi ikagabanya ububyimbirwe binyuze mu gukora kwa NF-κB. Hakoreshejwe uruhu rwa ex vivo rw’umugore w’imyaka 31 muzima, uruhu rwavuwe mbere n’icyayi cyera cyangwa icyayi kibisi byagaragaje ko uturemangingo twa Langerhans (uturemangingo twitwa antigen dushinzwe kwinjiza ubudahangarwa mu ruhu) nyuma yo kubona urumuri rwa UV.
Mu buryo bwakoreshejwe mu gushushanya imbeba, gukoresha icyayi kibisi mu mwanya wacyo mbere yo kwanduzwa n’imiraba ya UV byatumye erythema igabanuka, uruhu rugabanuka, ndetse n’imikorere ya myeloperoxidase igabanuka. Bishobora kandi kubuza 5-α-reductase.
Ubushakashatsi bwinshi bwakorewe ku bantu bwasesenguye ibyiza bishobora guterwa no gukoresha icyayi kibisi mu mwanya wacyo. Gukoresha icyayi kibisi mu mwanya wacyo byabujije 5-α-reductase kandi binatuma ingano ya microcomedone igabanuka mu gihe cy'ibiheri bya microcomedonal. Mu bushakashatsi buto bwakorewe ku bantu bwamaze ibyumweru bitandatu, amavuta arimo EGCG yagabanyije hypoxia-inducible factor 1 α (HIF-1α) na vascular endothelial growth factor (VEGF), bigaragaza ubushobozi bwo gukumira telangiectasias. Mu bushakashatsi bwakozwe ku buryo bubiri, icyayi kibisi, icyayi cyera, cyangwa vehicle byashyizwe ku matako y'abakorerabushake 10 bazima gusa. Hanyuma uruhu rwashyizwemo imirasire ya 2 × minimum erythema dose (MED) ya UVR ikoreshwa n'izuba. Biopsies z'uruhu zavuye muri izi mbuga zagaragaje ko gukoresha icyayi kibisi cyangwa cyera bishobora kugabanya cyane igabanuka ry'uturemangingo twa Langerhans, hashingiwe ku kuba CD1a ari nziza. Habayeho kandi gukumira igice cya ADN ya oxidative iterwa na UV, nk'uko bigaragazwa no kugabanuka k'urugero rwa 8-OHdG. Mu nyigo itandukanye, abakorerabushake 90 bakuru bashyizwe mu matsinda atatu: Nta muti, icyayi kibisi gikoreshwa mu gusukura, cyangwa icyayi cyera gikoreshwa mu gusukura. Buri tsinda ryagabanyijwemo ibice bitandukanye by'imirasire ya UV. Byagaragaye ko ikintu cyo kurinda izuba mu mubiri ari hafi SPF 1.
3.6. Marigold
3.6.1. Amateka, Imikoreshereze, Ibirego
Marigold, Calendula officinalis, ni ikimera cy’indabyo gifite impumuro nziza kandi gishobora kuvura. Cyakoreshejwe mu buvuzi gakondo mu Burayi no muri Leta Zunze Ubumwe za Amerika nk'umuti uvura ubushye, ibikomere, ibisebe n'uduheri. Marigold kandi yagaragaje ingaruka zo kurwanya kanseri mu bwoko bwa kanseri y'uruhu idafite melanoma.
3.6.2. Imiterere n'uburyo bwo gukora
Ibice by'ingenzi bigize marigold ni steroid, terpenoids, alcohols za triterpene zidafite ibara kandi zikozwe mu buryo bwa esterified, aside phenolic, flavonoids, n'ibindi binyabutabire. Nubwo ubushakashatsi bumwe bwagaragaje ko gukoresha marigold extract hejuru bishobora kugabanya ubukana n'ububabare bw'uruhu rw'imirasire ku barwayi bahabwa imirasire ya kanseri y'ibere, andi magerageza y'ubuvuzi yagaragaje ko nta gaciro gakomeye ugereranyije no gukoresha amavuta yo mu mazi gusa.
3.6.3. Ibimenyetso bya siyansi
Marigold yagaragaje ubushobozi bwo kurwanya indwara ziterwa n’uturemangingo tw’umubiri ndetse n’ingaruka zabyo ku turemangingo twa kanseri y’umuntu mu buryo bwa “in vitro human skin model”. Mu nyigo yakozwe muri “in vitro”, amavuta arimo amavuta ya calendula yapimwe hifashishijwe spectrophotometric ya UV maze aboneka ko afite ubushobozi bwo kuyungurura hagati ya 290-320 nm; ibi byafashwe nk'aho bivuze ko gukoresha aya mavuta bitanga uburinzi bwiza ku zuba. Ariko, ni ngombwa kumenya ko iki atari ikizamini cya “in vivo” cyabaraga urugero rw’umuti wa erythema mu bantu kandi ntibirasobanuka neza uburyo ibi byasobanura mu igeragezwa ry’ubuvuzi.
Mu buryo bwa "in vivo murine", ikinyabutabire cya marigold cyagaragaje ingaruka zikomeye ku ruhu nyuma yo kwibasirwa n'imirasire y'izuba. Mu bundi bushakashatsi, bwakorewe ku mbeba z'aba albino, gukoresha amavuta ya calendula essential oil ku mubiri byagabanyije malondialdehyde (ikimenyetso cy'umuvuduko wa oxidative) mu gihe byongera urugero rwa catalase, glutathione, superoxide dismutase, na aside ascorbic mu ruhu.
Mu bushakashatsi bwakozwe mu byumweru umunani ku bantu 21, bwagaragaje ko gukoresha amavuta ya calendula ku matama byongera ubukana bw'uruhu ariko nta ngaruka zikomeye byagize ku ruhu rworoshye.
Imbogamizi zishobora guterwa no gukoresha marigold mu kwisiga ni uko marigold izwiho gutera dermatitis iterwa n’ubwivumbure, kimwe n’abandi bantu benshi bo mu muryango wa Compositae.
3.7. Ingano
3.7.1. Amateka, Imikoreshereze, Ibirego
Pomegranate, Punica granatum, ifite ubushobozi bukomeye bwo kurwanya indwara kandi yakoreshejwe mu bintu byinshi nk'umuti urinda indwara. Ifite ubwinshi bwa antioxidant ituma iba ikintu gishimishije mu miterere y'ubwiza.
3.7.2. Imiterere n'uburyo bwo gukora
Ibice bigize pomegranate bigira uruhare runini mu mikorere yabyo ni tannins, anthocyanins, aside ascorbic, niacin, potasiyumu, na alkaloids za piperidine. Ibi bice bigira uruhare runini mu mikorere yabyo bishobora gukurwa mu mutobe, imbuto, igishishwa, igishishwa, umuzi, cyangwa igiti cy'ipomegranate. Bimwe muri ibi bice bivugwa ko bigira ingaruka ku bibyimba, kurwanya ububyimbirwe, kurwanya mikorobe, kurwanya antioxidant, no kurinda ubwiza bw'umubiri. Byongeye kandi, pomegranate ni isoko ikomeye ya polyphenols. Aside ellegic, igice cy'imvange y'ipomegranate, ishobora kugabanya ibara ry'uruhu. Kubera ko ari ikintu cyiza cyo kurwanya gusaza, ubushakashatsi bwinshi bwakozweho ubushakashatsi ku buryo bwo kongera kwinjira k'uruhu rw'iyi mvange kugira ngo ikoreshwe mu mubiri.
3.7.3. Ibimenyetso bya siyansi
Imbuto y'imbuto z'amakomamanga irinda fibroblasts z'abantu, muri vitro, urupfu rw'uturemangingo duterwa na UV; birashoboka ko biterwa no kugabanuka k'imikorere ya NF-κB, kugabanuka kwa caspace-3 ya proapoptotic, no kwiyongera k'ubuziranenge bwa ADN. Igaragaza ingaruka zo kurwanya ikibyimba cy'uruhu muri vitro kandi ikabuza uburyo NF-κB na MAPK zihinduka bitewe na UVB. Gukoresha imbuto y'amakomamanga mu ruhu bigabanya COX-2 mu ruhu rw'ingurube rushya, bigatera ingaruka zikomeye zo kurwanya ububyimbirwe. Nubwo aside ellegic ikunze gufatwa nk'igice gikomeye cy'imbuto y'amakomamanga, icyitegererezo cya murine cyagaragaje imikorere yo kurwanya ububyimbirwe hamwe n'imbuto y'amakomamanga isanzwe ugereranije na aside ellegic yonyine. Gukoresha microemulsion y'imbuto y'amakomamanga hakoreshejwe polysorbate surfactant (Tween 80®) mu gihe cy'ibyumweru 12 ugereranije n'abantu 11, byagaragaje kugabanuka kwa melanin (kubera tyrosinase inhibition) no kugabanuka kwa erythema ugereranije n'uburyo imodoka zigenzura.
3.8. Soya
3.8.1. Amateka, Imikoreshereze, Ibirego
Soya ni ibiryo birimo poroteyine nyinshi hamwe n’ibintu bikora ku buzima bishobora kugira ingaruka ku gusaza. By’umwihariko, soya irimo isoflavones nyinshi, zishobora kugira ingaruka ku kurwanya kanseri ndetse n’ingaruka nk’iza estrogen bitewe n’imiterere ya diphenolic. Izi ngaruka nk’iza estrogen zishobora kurwanya zimwe mu ngaruka zo gucura ku busaza bw’uruhu.
3.8.2. Imiterere n'uburyo bwo gukora
Soya, ikomoka kuri Glycine maxi, ikungahaye kuri poroteyine kandi ikubiyemo isoflavones, harimo glycitein, equol, daidzein, na genistein. Izi isoflavones, zitwa kandi phytoestrogens, zishobora kugira ingaruka za estrogen ku bantu.
3.8.3. Ibimenyetso bya siyansi
Soya irimo isoflavones nyinshi zishobora kugabanya ubusaza. Mu zindi ngaruka za biyoloji, glycitein igaragaza ingaruka za antioxydants. Fibroblasts zo mu bwoko bwa dermal zavuwe na glycitein zagaragaje kwiyongera kw'ingirabuzimafatizo no kwimuka, kwiyongera k'uburyo bwa collagen I na III, no kugabanuka kwa MMP-1. Mu bushakashatsi butandukanye, isosi ya soya yahujwe n'isosi ya haematococcus (algae yo mu mazi meza nayo irimo antioxydants nyinshi), byagabanyije MMP-1 mRNA na poroteyine. Daidzein, isoflavone ya soya, yagaragaje ingaruka zo kurwanya iminkanyari, uruhu rutanga urumuri, kandi ifasha uruhu kumererwa neza. Diadzein ishobora gukora ikora ikoresheje estrogen-receptor-β mu ruhu, bigatuma habaho kwiyongera k'uburyo antioxydants zo mu mubiri no kugabanuka k'uburyo ibintu bya transcription bituma keratinocyte ikwirakwira no kwimuka. Isoflavonoid equol ikomoka kuri soya yongera kolagen na elastin kandi igabanya MMP mu mikurire y'uturemangingo.
Ubundi bushakashatsi bwakozwe mu mibonano mpuzabitsina bwagaragaje ko urupfu rw’uturemangingo duterwa na UVB rwagabanutse ndetse n’ubugari bw’uturemangingo mu turemangingo nyuma yo gukoresha isoflavone mu mubiri. Mu bushakashatsi bwakorewe ku bagore 30 bamaze gucura, gutanga isoflavone mu kanwa mu gihe cy’amezi atandatu byatumye ubugari bw’uturemangingo bwiyongereye ndetse n’ubwiyongere bwa kolajeni y’uruhu nk’uko byapimwe n’ibipimo by’uruhu mu bice birinzwe n’izuba. Mu bushakashatsi butandukanye, isoflavone za soya zavuguruwe zabujije urupfu rwa keratinocyte iterwa na UV ndetse zinagabanya TEWL, ubugari bw’uturemangingo, na erythema mu ruhu rw’imbeba rwagaragayemo UV.
Isuzuma ry’ibizamini bya RCT ry’abagore 30 bari hagati y’imyaka 45-55 ryagaragaje ko estrogen na genistein (soy isoflavone) byakoreshejwe ku ruhu mu gihe cy’ibyumweru 24. Nubwo itsinda ryakoresheje estrogen ku ruhu ryagize umusaruro mwiza, amatsinda yombi yagaragaje kolajeni yo mu maso yo mu bwoko bwa I na III yiyongera hashingiwe ku biopsies by’uruhu rwabanje kugaragara. Oligopeptides za Soy zishobora kugabanya igipimo cya erythema mu ruhu rwagaragayeho UVB (ku maboko) no kugabanya uturemangingo twatwitswe n’izuba na cyclobutene pyrimidine dimers mu turemangingo tw’uruhu twahishijwe UVB. Igerageza ryakozwe mu byumweru 12 ryakozwe n’abagore 65 bafite ikibazo cyo kwangirika k’isura mu buryo buciriritse ryagaragaje ko ibara ry’uruhu ryazamutse, amabara, ububobere, imirongo mito, imiterere y’uruhu, n’imiterere y’uruhu ugereranije n’imodoka. Muri rusange, ibi bintu bishobora gutanga ingaruka zishobora kugabanya gusaza, ariko hakenewe igerageza rikomeye ry’ubuvuzi kugira ngo rigaragaze neza akamaro karyo.
4. Ikiganiro
Ibikomoka ku bimera, harimo n'ibyavuzwe hano, bifite ingaruka zishobora kugabanya gusaza. Uburyo ibimera birwanya gusaza birimo ubushobozi bwo gukuraho antioxydants zikoreshwa ku ruhu, kwiyongera k'uburinzi bw'izuba, kwiyongera k'ubushuhe bw'uruhu, hamwe n'ingaruka nyinshi zituma collagen ikorwa cyangwa ikagabanuka. Zimwe muri izi ngaruka ni nto ugereranije n'imiti, ariko ibi ntibigabanya inyungu zishobora kuboneka iyo zikoreshejwe hamwe n'izindi ngamba nko kwirinda izuba, gukoresha imiti irinda izuba, kwisiga buri munsi no kuvura indwara z'uruhu zisanzwe.
Byongeye kandi, ibimera bitanga ibindi bintu bikora ku mubiri ku barwayi bakunda gukoresha ibintu "bisanzwe" gusa ku ruhu rwabo. Nubwo ibi bintu biboneka mu bimera, ni ngombwa gushimangira ku barwayi ko ibi bidasobanura ko ibi bintu nta ngaruka mbi bigira, mu by'ukuri, ibimera byinshi bizwiho kuba intandaro y'uburwayi bwo mu mutwe butera allergie.
Kubera ko ibikomoka ku bimera bidasaba ibimenyetso bimwe kugira ngo bigaragaze ko bifite akamaro, akenshi biragoye kumenya niba ibivugwa ku ngaruka zo kurwanya gusaza ari ukuri. Ariko, bimwe mu bimera bivugwa hano bifite ingaruka zishobora kurwanya gusaza, ariko hakenewe igeragezwa rikomeye ry’ubuvuzi. Nubwo bigoye kumenya uburyo ibi bimera bizagirira akamaro abarwayi n’abaguzi mu gihe kizaza, birashoboka cyane ko kuri byinshi muri ibi bimera, imiti ibikora nk'ibicuruzwa izakomeza gushyirwa mu bikorwa nk'ibicuruzwa byo kwita ku ruhu kandi niba bigumana umutekano munini, byemewe cyane n'abaguzi, kandi bihendutse, bizakomeza kuba bimwe mu bikorwa bisanzwe byo kwita ku ruhu, bitanga inyungu nke ku buzima bw'uruhu. Ariko, ku mubare muto w'ibi bimera, ingaruka nini ku baturage muri rusange zishobora kuboneka binyuze mu gushimangira ibimenyetso by'imikorere yabyo mu mubiri, binyuze mu isuzuma risanzwe rya biomarker ripima umusaruro mwinshi hanyuma bigashyirwa ku ntego nziza zo gupima igeragezwa ry’ubuvuzi.
Igihe cyo kohereza: Gicurasi-11-2023
