Corydalis Ikuramo Tetrahydropalmatine (dl-THP)
Tetrahydropalmatine (THP), izwi kandi nka dl-THP, Corydalin hydrochloride, cyangwa Corydalin Tube Extract, ni uruganda rwashyizwe mu bwoko bwa alkaloide isoquinoline. Yakuwe mubijumba byicyatsi cyabashinwa Corydalis yanhusuo. THP ni ibara ritagira ibara cyangwa ryijimye ry'umuhondo kristaline ifite uburyohe busharira gato hamwe no gushonga kwa 147-149 ° C. Ntishobora gushonga mumazi ariko irashonga cyane muri ether, chloroform, na Ethanol. Hydrochloride hamwe nu munyu wa sulfate birashonga mumazi.
THP yakozweho ubushakashatsi ku ngaruka zitandukanye za farumasi, harimo analgesic, anesthetic, neuroprotective, igiteranyo cya antiplatelet, antiulcer, antitumor, hamwe nuburyo bwo kurwanya ibiyobyabwenge. Byizerwa ko bigira ingaruka zidasanzwe muguhindura ibikorwa bya reseptor yo hagati ya dopamine kandi byagaragaje ubushobozi bwo kurinda neurone gukomeretsa ischemic. Byongeye kandi, THP yerekanye ingaruka zo guteranya antiplatelet kandi hakozwe ubushakashatsi ku bushobozi ifite mu kuvura ibisebe, kubuza gukura kw'ibibyimba, no gufasha mu biyobyabwenge.
Muri rusange, Tetrahydropalmatine (dl-THP) ni uruganda rufite imiti itandukanye ya farumasi kandi rwakorewe ubushakashatsi bwimbitse kubishobora gukoreshwa. Kubindi bisobanuro hamagaragrace@biowaycn.com.
Dore ibicuruzwa biranga Tetrahydropalmatine (THP) hamwe nubuzima bwabo ：
1. Ibyiza byo gusesengura:THP yerekana ingaruka zidasanzwe muguhindura ibikorwa bya reseptor ya dopamine yo hagati, itanga ububabare butagira imbaraga zikomeye zo kubatwa.
2. Ingaruka za Neuroprotective:THP yerekanye ubushobozi mu kurinda neurone gukomeretsa ischemic, kugabanya apoptose ya neuronal, no kugabanya urugero rwa glutamate mu bwonko, ibyo bikaba bishobora kugira uruhare mu mikorere ya neuroprotective.
3. Igiteranyo cya Antiplatelet:THP yasanze ibuza gukusanya platine, bishobora kugabanya ibyago byo gutembera kw'amaraso hamwe n'indwara zifata umutima.
4. Inkunga yubuzima bwa Gastrici:THP yerekanye ingaruka zo kurwanya ibisebe kandi irashobora gufasha mukugabanya ururenda rwa acide gastricike, itanga uburuhukiro bwibisebe byigifu nibihe bijyanye.
5. Igikorwa gishobora kurwanya antitumor:THP yerekanye ingaruka za cytotoxic kuri selile yibibyimba, byerekana uruhare rushoboka mukubuza gukura kwikibyimba.
6. Kurwanya Ibiyobyabwenge:THP yakozweho ubushakashatsi ku bushobozi ifite bwo kugabanya ibimenyetso byo kwikuramo bifitanye isano na opioide ndetse n’ibiyobyabwenge bitera imbaraga, bitanga amasezerano yo kuvura ibiyobyabwenge no kwirinda indwara.
Ibiranga byerekana inyungu zitandukanye zubuzima nibishobora kuvura Tetrahydropalmatine (THP).
Tetrahydropydalin (dl-THP) ni iyitwa isoquinoline alkaloide kandi ni alkaloide, cyane cyane mu bwoko bwa Corydalis lucidum (Yan Hu Suo), ariko no mu bindi bimera nka Stephania rotunda. Ibi bimera bifite imikoreshereze gakondo mubuvuzi bwibimera.Corydalis ni igihingwa cyatsi kibisi, uburebure bwa cm 10 kugeza kuri 20, hamwe nibijumba. Igiti cyacyo cyo hejuru-kigufi ni kigufi kandi cyoroshye, hamwe nubunini hejuru yigitereko. Amababi yibanze namababi ya cauline birasa muburyo, hamwe nibiti; amababi ya cauline arasimburana, hamwe nibibabi 2 na 3. Ikibabi cya kabiri gikunze gucikamo ibice bituzuye kandi gifunze cyane. Amababi mato ni maremare, oval, cyangwa oval. Umurongo, uburebure bwa cm 2, hamwe na apex itagaragara cyangwa ityaye kandi impande nziza. Inflorescence yayo ni ubwoko bwamoko, hamwe nibibabi cyangwa amababi atandukanye; uduce twinshi ni lanceolate; indabyo zitukura-zijimye kandi zikura mu buryo butambitse kuri pedicel yoroheje, zifite uburebure bwa mm 6; calyx igwa kare; ibibabi ni 4 naho indaya zo hanze ni 2 Ibice ni binini gato, bifite impande zijimye kandi hagati yubururu-bwijimye. Hariho igice kimwe cyo hejuru, kandi umurizo urambuye muri spur ndende. Uburebure bwa spur bufite hafi kimwe cya kabiri cyuburebure. Ibice 2 by'imbere biragufi kuruta ibice 2 byo hanze. Impera yo hejuru ni ubururu-ibara ry'umuyugubwe kandi irakize, naho igice cyo hepfo ni umutuku; Stamens ni 6, kandi filaments ihujwe mumigozi ibiri, buri hamwe na antheri 3; intanga ngore iringaniye-silindrike, imiterere ni ngufi kandi yoroheje, kandi gusebanya ni 2, nk'ikinyugunyugu gito. Imbuto zacyo ni capsule. Corydalis ikorerwa cyane cyane mumisozi cyangwa mubyatsi. Ahantu h’umusaruro mwinshi harimo Zhejiang, Hebei, Shandong, Jiangsu, nahandi.
| Isesengura | Ibisobanuro |
| Suzuma | Tetrahydropalmatine ≥98% |
| Kugaragara | Ifu yumuhondo yoroheje kugeza Ifu yera |
| Ivu | ≤0.5% |
| Ubushuhe | ≤5.0% |
| Imiti yica udukoko | Ibibi |
| Ibyuma biremereye | ≤10ppm |
| Pb | ≤2.0ppm |
| As | ≤2.0ppm |
| Impumuro | Ibiranga |
| Ingano y'ibice | 100% kugeza kuri 80 mesh |
| Microbiologiya: | |
| Bagiteri zose | 0001000cfu / g |
| Fungi | ≤100cfu / g |
| Salmgosella | Ibibi |
| Coli | Ibibi |
Dore inganda zikoresha ibicuruzwa bya Tetrahydropalmatine (THP):
1. Imiti:THP ikoreshwa mu nganda zimiti mugutezimbere imiti igabanya ububabare n imiti ya neuroprotective.
2. Intungamubiri:THP ikoreshwa munganda zintungamubiri mugutegura inyongera zigamije kugabanya ububabare nubufasha bwubuzima bwa gastric.
3. Ikoranabuhanga mu binyabuzima:THP isanga porogaramu muri biotechnologie yubushakashatsi kubuvuzi bwa antiplatelet hamwe nibishobora kuvura kanseri.
4. Ubuvuzi:THP yinjizwa mubicuruzwa byubuzima kugirango bikemure ibiyobyabwenge nibimenyetso byo kwikuramo bijyana na opioid no gukoresha imbaraga.
5. Cosmeceuticals:THP ishakishwa muri cosmeceuticals kubuzima bwuruhu rushobora no gukoreshwa.
Izi nganda zerekana uburyo butandukanye bushobora gukoreshwa bwa Tetrahydropalmatine (THP) mugutezimbere ibicuruzwa bitandukanye no mubushakashatsi.
Ibicuruzwa byacu byakozwe hifashishijwe ingamba zikomeye zo kugenzura ubuziranenge kandi byubahiriza ibipimo bihanitse byo gutunganya umusaruro. Dushyira imbere umutekano nubuziranenge bwibicuruzwa byacu, tukemeza ko byujuje ibisabwa n’amabwiriza y’inganda. Uku kwiyemeza ubuziranenge bigamije gushiraho ikizere nicyizere mubicuruzwa byacu. Ibikorwa rusange byumusaruro nuburyo bukurikira:
Ububiko:Bika ahantu hakonje, humye, kandi hasukuye, Kurinda ubushuhe numucyo utaziguye.
Igipapuro kinini:20~25kg / ingoma.
Igihe cyo kuyobora:Iminsi 7 nyuma yo gutumiza.
Ubuzima bwa Shelf:Imyaka 2.
Icyitonderwa:Ibisobanuro byihariye birashobora kugerwaho.
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