Methyltetrahydrofolate Kalisiyumu （5MTHF-Ca)
Kalisiyumu yuzuye ya Methyltetrahydrofolate (5-MTHF-Ca) nuburyo bwa folate iboneka cyane kandi ishobora gukoreshwa numubiri byoroshye.Numunyu wa calcium ya methyltetrahydrofolate, nuburyo bukora bwa folate mumubiri.Folate ni vitamine B y'ingenzi igira uruhare runini mu ngirabuzimafatizo zitandukanye, harimo synthesis ya ADN, umusaruro w'amaraso atukura, n'imikorere ya sisitemu y'imitsi.
MTHF-Ca ikoreshwa nkinyongera yimirire kugirango ishyigikire urugero rwa folate kubantu bashobora kugira ikibazo cyo guhinduranya cyangwa kwinjiza uburyo bwa sintetike ya acide folike iboneka mubiribwa bikomeye hamwe ninyongera.Ni ingirakamaro cyane cyane kubantu bafite itandukaniro rishingiye ku ngirabuzima fatizo zishobora kwangiza folate metabolism.
Kwiyongera hamwe na MTHF-Ca birashobora gufasha gufasha ubuzima bwiza muri rusange, cyane cyane mubice nkubuzima bwumutima nimiyoboro y'amaraso, iterambere ry'imitsi itwite mugihe utwite, imikorere yubwenge, hamwe no kugenzura imyumvire.Ni ngombwa kumenya ko MTHF-Ca igomba gukoreshwa iyobowe n’inzobere mu buzima, cyane cyane ku bantu bafite ubuvuzi bwihariye cyangwa abafata imiti imwe n'imwe.
| Izina RY'IGICURUZWA： | L-5-Methyltetrahydrofolate calcium |
| Synonyme： | 6S-5-Methyltetrahydrofolate calcium; Kalisiyumu L-5-Methyltetrahydrofolate; Kalisiyumu ya Levomefolate; |
| Inzira ya molekulari: | C20H23CaN7O6 |
| Uburemere bwa molekile: | 497.52 |
| URUBANZA Oya: | 151533-22-1 |
| Ibirimo: | ≥ 95.00% na HPLC |
| Kugaragara: | Ifu yera kugeza yoroheje umuhondo wa kristaline |
| Igihugu bakomokamo: | Ubushinwa |
| Ipaki: | 20kg / ingoma |
| Ubuzima bwa Shelf: | Amezi 24 |
| Ububiko: | Komeza ahantu hakonje & humye. |
| Ibintu | Ibisobanuro | Ibisubizo |
| Kugaragara | Ifu yera cyangwa itari yera | Emeza |
| Kumenyekanisha | Ibyiza | Emeza |
| Kalisiyumu | 7.0% -8.5% | 8.4% |
| D-5-Methylfolate | ≤1.0 | Ntibimenyekana |
| Ibisigisigi byo gutwikwa | ≤0.5% | 0.01% |
| Amazi | ≤17.0% | 13.5% |
| Suzuma (HPLC) | 95.0% -102.0% | 99.5% |
| Ivu | ≤0.1% | 0,05% |
| Icyuma kiremereye | ≤20 ppm | Emeza |
| Umubare wuzuye | 0001000cfu / g | Yujuje ibyangombwa |
| Umusemburo & Mold | ≤100cfu / g | Yujuje ibyangombwa |
| E.coil | Ibibi | Ibibi |
| Salmonella | Ibibi | Ibibi |
Bioavailability:MTHF-Ca ni bioavailable cyane ya folate, bivuze ko ishobora kwinjizwa byoroshye no gukoreshwa numubiri.Ibi ni ngombwa kuko abantu bamwe bashobora kugira ikibazo cyo guhindura aside folike ya sintetike muburyo bukora.
Uburyo bukora bwa folate:MTHF-Ca nuburyo bukora bwa folate, buzwi nka methyltetrahydrofolate.Iyi fomu ikoreshwa byoroshye numubiri kandi ntisaba ubundi buryo bwo guhindura ibintu.
Umunyu wa Kalisiyumu:MTHF-Ca ni umunyu wa calcium, bivuze ko uhambiriye kuri calcium.Ibi bitanga inyungu yinyongera ya calcium hamwe ninkunga ya folate.Kalisiyumu ningirakamaro kubuzima bwamagufwa, imikorere yimitsi, kwanduza imitsi, nibindi bikorwa byumubiri.
Birakwiriye kubantu bafite itandukaniro ryihariye:MTHF-Ca ifitiye akamaro kanini abantu bafite ihindagurika rishingiye ku gitsina rishobora kubangamira folate metabolism.Ihindagurika rishingiye ku ngirabuzima fatizo rishobora kugira ingaruka ku bushobozi bw'umubiri bwo guhindura aside folike mu buryo bukora, bigatuma hiyongeraho folate ikora.
Shyigikira ibintu bitandukanye byubuzima:Inyongera ya MTHF-Ca irashobora gushyigikira ubuzima rusange n'imibereho myiza.Ifite akamaro kanini kubuzima bwumutima nimiyoboro y'amaraso, gukura kw'imitsi itwite mugihe utwite, imikorere yubwenge, no kugenzura imyumvire.
Kalisiyumu yuzuye ya Methyltetrahydrofolate (MTHF-Ca) itanga inyungu nyinshi mubuzima:
Inkunga ya metabolism:MTHF-Ca ni bioavailable cyane kandi ikora ya folate.Ifasha gushyigikira metabolism ya folate yumubiri, ifite akamaro kanini muri synthesis ya ADN, kubyara amaraso atukura, hamwe nimikorere rusange ya selile.
Ubuzima bw'umutima n'imitsi:Urwego rwa folate ruhagije ni ngombwa kubuzima bwumutima.Inyongera ya MTHF-Ca irashobora gufasha kugabanya urugero rwa homocysteine, aside amine, iyo izamutse, ifitanye isano no kwiyongera kwindwara zifata umutima.
Inkunga yo gutwita:MTHF-Ca ni ingenzi mugihe utwite, kuko ifasha kwirinda inenge zifata imitsi mu mikurire.Birasabwa kubagore bafite imyaka yo kubyara kugirango barebe ko bafite folate ihagije, cyane cyane mugihe cyambere cyo gutwita.
Amabwiriza agenga imyitwarire:Folate igira uruhare runini muri synthesis ya neurotransmitter.Urwego rwa folate ruhagije rushyigikira umusaruro wa serotonine, dopamine, na norepinephrine, bifite akamaro kanini mugutunganya umwuka.Inyongera ya MTHF-Ca irashobora kugirira akamaro abantu bafite ibibazo byo kwiheba, nko kwiheba.
Imikorere yo kumenya:Folate ningirakamaro mumikorere yubwenge nubuzima bwubwonko.MTHF-Ca inyongera irashobora gushyigikira kwibuka, kwibanda, hamwe nibikorwa rusange byubwenge, cyane cyane kubantu bakuze.
Inkunga y'imirire:Inyongera ya MTHF-Ca irashobora kugirira akamaro abantu bafite ihindagurika rishingiye ku ngirabuzimafatizo bigira ingaruka kuri metabolism ya folate.Aba bantu barashobora kugira ikibazo cyo guhindura aside folike ya sintetike muburyo bukora.MTHF-Ca itanga uburyo bukora bwa folate mu buryo butaziguye, ukuraho ibibazo byose byo guhindura.
Intungamubiri ninyongera zimirire:MTHF-Ca isanzwe ikoreshwa nkibintu byingenzi byongera intungamubiri nintungamubiri.Itanga bioavailable cyane ya folate, itanga inyungu nyinshi mubuzima, nkuko byavuzwe haruguru.
Gukomeza ibiryo n'ibinyobwa:MTHF-Ca irashobora kwinjizwa mubiribwa n'ibinyobwa kugirango ikomeze hamwe na folate.Ibi ni ingenzi cyane kubicuruzwa byita kubaturage bafite ikibazo cya folate cyangwa kwiyongera kwa folate, nk'abagore batwite cyangwa abantu bafite ubuzima runaka.
Imiti ya farumasi:MTHF-Ca irashobora gukoreshwa muburyo bwa farumasi nkibikoresho bikora.Irashobora gukoreshwa mumiti igamije ibihe byihariye bijyanye no kubura folate cyangwa kwangirika kwa folate metabolism, nka anemia cyangwa indwara zimwe na zimwe.
Kwitaho no kwisiga:MTHF-Ca rimwe na rimwe ishyirwa mubicuruzwa byita kumuntu no kwisiga kubera inyungu zishobora kugira kubuzima bwuruhu.Folate igira uruhare mubikorwa bitandukanye byuruhu kandi birashobora kugira uruhare mubuzima rusange no kugaragara.
Ibiryo by'amatungo:MTHF-Ca irashobora kandi kwinjizwa mubiryo byamatungo kugirango hongerwe inyamaswa na folate.Ibi ni ingirakamaro cyane cyane mu nganda z’ubworozi n’inkoko, aho ari ngombwa ko habaho imirire ihagije kugirango imikurire myiza n’ubuzima ari ngombwa.
Izi porogaramu zerekana uburyo butandukanye bwa MTHF-Ca hamwe n’uburyo bushobora gukoreshwa mu nganda zitandukanye kugira ngo bikemure ibibazo by’ubuzima bijyanye na folate hamwe n’imirire.Nyamara, ni ngombwa gukurikiza umurongo ngenderwaho ukwiye no kugisha inama abanyamwuga mugihe winjije MTHF-Ca mubicuruzwa cyangwa ibicuruzwa.
Isoko ry'ibikoresho fatizo:Inzira itangirana no gushakisha ibikoresho byiza byo mu rwego rwo hejuru.Ibikoresho byibanze bisabwa kugirango umusaruro wa MTHF-Ca ni aside folike hamwe n umunyu wa calcium.
Guhindura aside folike kuri 5,10-Methylenetetrahydrofolate (5,10-MTHF):Acide Folike ihinduka 5,10-MTHF binyuze muburyo bwo kugabanya.Iyi ntambwe mubisanzwe ikubiyemo gukoresha kugabanya ibintu nka sodium borohydride cyangwa izindi catalizaires zikwiye.
Guhindura 5,10-MTHF kuri MTHF-Ca:5,10-MTHF yongeye gukoreshwa hamwe n'umunyu wa calcium ukwiye, nka calcium hydroxide cyangwa calcium karubone, kugirango ube Kalisiyumu ya Methyltetrahydrofolate (MTHF-Ca).Iyi nzira ikubiyemo kuvanga reaction no kubemerera kubyitwaramo mugihe cyagenzuwe, harimo ubushyuhe, pH, nigihe cyo kubyitwaramo.
Kwezwa no kuyungurura:Nyuma yo kubyitwaramo, igisubizo cya MTHF-Ca gikora inzira yo kwezwa nko kuyungurura, centrifugation, cyangwa ubundi buryo bwo gutandukana kugirango ukureho umwanda nibicuruzwa bishobora kuba byarakozwe mugihe cya reaction.
Kuma no gukomera:Igisubizo cya MTHF-Ca gisukuye noneho kiratunganywa kugirango gikureho ubuhehere burenze kandi bushimangire ibicuruzwa byanyuma.Ibi birashobora kugerwaho hifashishijwe tekinike nko kumisha spray cyangwa gukonjesha, bitewe nuburyo bwibicuruzwa wifuza.
Kugenzura ubuziranenge no kugerageza:Igicuruzwa cya nyuma cya MTHF-Ca gikorerwa ingamba zikomeye zo kugenzura ubuziranenge kugira ngo isukure, ituze, kandi yubahirize ibipimo ngenderwaho by’ubuziranenge.Ibi birashobora kubamo kwipimisha umwanda, imbaraga, nibindi bipimo bifatika.
Gupakira no kubika:MTHF-Ca yapakiwe mubikoresho byabigenewe, byemeza neza ibimenyetso byububiko kugirango bibungabunge ubusugire bwabyo kandi bihamye.Ubusanzwe ibikwa ahantu humye, hakonje kure yizuba ryizuba.
Ububiko: Bika ahantu hakonje, humye, kandi hasukuye, Kurinda ubushuhe n’umucyo utaziguye.
Igipapuro kinini: 25kg / ingoma.
Igihe cyo kuyobora: iminsi 7 nyuma yo gutumiza.
Ubuzima bwa Shelf: imyaka 2.
Icyitonderwa: Ibisobanuro byihariye nabyo birashobora kugerwaho.
20kg / umufuka 500kg / pallet
Gupakira neza
Umutekano wibikoresho
Express
Munsi ya 100kg, Iminsi 3-5
Serivisi ku muryango byoroshye gufata ibicuruzwa
Ku nyanja
Kurenga 300 kg, Hafi Iminsi 30
Icyambu kugeza ku cyambu serivisi yumwuga yemewe arakenewe
Na Air
100kg-1000kg, Iminsi 5-7
Ikibuga cyindege cya serivise yikibuga cyumwuga gikenewe
Methyltetrahydrofolate Kalisiyumu （5-MTHF-Ca)ni Icyemezo cya ISO, Icyemezo cya HALAL, na KOSHER icyemezo.
Itandukaniro riri hagati yisekuru ya kane ya acide folike (5-MTHF) na aside folike gakondo iri mumiterere yimiti yabo hamwe na bioavailable mumubiri.
Imiterere ya shimi:Acide folike gakondo nuburyo bukoreshwa bwa folate ikeneye gutera intambwe nyinshi zo guhinduka mumubiri mbere yuko ikoreshwa.Ku rundi ruhande, aside folike yo mu gisekuru cya kane, izwi kandi nka 5-MTHF cyangwa Methyltetrahydrofolate, nuburyo bukora, bioavailable ya folate idasaba guhinduka.
Bioavailable:Acide folike gakondo igomba guhindurwa muburyo bukora, 5-MTHF, binyuze mumikorere ya enzymatique mumubiri.Iyi nzira yo guhinduka iratandukanye kubantu kandi irashobora guterwa nubwoko butandukanye cyangwa izindi mpamvu.Ibinyuranye, 5-MTHF isanzwe mubikorwa byayo, bituma byoroha kuboneka no gufata selile.
Gukuramo no gukoresha:Gukuramo aside folike gakondo bibaho mu mara mato, aho bigomba guhinduka muburyo bukora na enzyme dihydrofolate reductase (DHFR).Nyamara, iyi nzira yo guhindura ntabwo ikora neza kubantu bamwe, biganisha kuri bioavailable yo hasi.5-MTHF, kuba uburyo bukora, byoroshye kwinjizwa no gukoreshwa numubiri, ukarenga inzira yo guhinduka.Ibi bituma iba uburyo bwatoranijwe kubantu bafite ihindagurika ryimiterere cyangwa imiterere bigira ingaruka kuri metabolism folate.
Ubuzima bwiza kubantu bamwe:Bitewe no gutandukanya kwinjiza no gukoresha, 5-MTHF ifatwa nkibikwiye kubantu bafite itandukaniro rishingiye ku ngirabuzima fatizo, nka mutation ya MTHFR, ishobora kubangamira ihinduka rya aside folike mu mikorere yayo.Kuri aba bantu, gukoresha 5-MTHF mu buryo butaziguye birashobora kwemeza urugero rwa folate mu mubiri kandi bigashyigikira ibikorwa bitandukanye byibinyabuzima.
Inyongera:Acide folike gakondo iboneka mubyongeweho, ibiryo bikomejwe, nibiribwa bitunganijwe, kuko bihamye kandi bihenze kubyara umusaruro.Ariko, harikwiyongera kuboneka kwa 5-MTHF yinyongera itanga ifishi ikora itaziguye, ishobora kugirira akamaro abantu bafite ikibazo cyo guhindura aside folike.
Ingaruka ziterwa na aside folike yo mu gisekuru cya kane (5-MTHF) muri rusange ni gake kandi yoroheje, ariko ni ngombwa kumenya ingaruka zishobora guterwa:
Allergic reaction:Kimwe ninyongera cyangwa imiti, reaction ya allergique irashoboka.Ibimenyetso bishobora kubamo guhubuka, guhinda, kubyimba, kuzunguruka, cyangwa guhumeka neza.Niba uhuye na kimwe muri ibyo bimenyetso, shakisha ubuvuzi bwihuse.
Ibibazo byigifu:Abantu bamwe barashobora kugira ikibazo cyo mu gifu, nko kugira isesemi, kubyimba, gaze, cyangwa impiswi.Ibi bimenyetso mubisanzwe nibyigihe gito kandi bigabanuka nkuko umubiri umenyera kubwinyongera.
Imikoranire n'imiti:5-MTHF irashobora gukorana n'imiti imwe n'imwe, harimo imiti ikoreshwa mu kuvura kanseri, anticonvulsants, methotrexate, na antibiotike zimwe na zimwe.Ni ngombwa kuvugana nubuvuzi bwawe niba ufata imiti iyo ari yo yose kugirango urebe ko nta mikoranire ishobora kubaho.
Kurenza urugero cyangwa kurenza urugero rwa folate:Nubwo bidasanzwe, gufata folate birenze urugero (harimo 5-MTHF) birashobora gutuma amaraso menshi ya folate.Ibi birashobora guhisha ibimenyetso byo kubura vitamine B12 kandi bikagira ingaruka ku gusuzuma no kuvura ibintu bimwe na bimwe.Ni ngombwa gukurikiza dosiye isabwa no kugisha inama inzobere mu buvuzi kugirango ikuyobore.
Ibindi bitekerezo:Abagore batwite cyangwa abateganya gusama bagomba kuvugana n’ushinzwe ubuzima mbere yo gufata urugero rwinshi rwa 5-MTHF, kubera ko gufata folate birenze urugero bishobora guhisha ibimenyetso byerekana kubura vitamine B12, ari ngombwa mu mikurire y’imitsi mu nda.
Kimwe ninyongeramusaruro cyangwa imiti iyo ari yo yose, birakenewe ko tuganira kubijyanye no gukoresha aside folike yo mu gisekuru cya kane (5-MTHF) hamwe n’ushinzwe ubuzima, cyane cyane niba ufite ubuzima bw’ibanze cyangwa ufata indi miti.Barashobora gutanga inama kugiti cyabo ukurikije ibyo ukeneye kandi bagafasha gukurikirana ingaruka zose zishobora kubaho.
Acide ya folike yo mu gisekuru cya kane, izwi kandi nka 5-methyltetrahydrofolate (5-MTHF), ni uburyo bukora bwa biologiya bwa folate bworoshye cyane kandi bugakoreshwa n'umubiri ugereranije no kongera aside folike gakondo.Hano hari ubushakashatsi bwa siyansi bushigikira imikorere yabwo:
Kongera bioavailable:5-MTHF yerekanwe ko ifite bioavailable nyinshi kuruta aside folike.Ubushakashatsi bwasohotse mu kinyamakuru cyo muri Amerika cyita ku mirire ya Clinical bwagereranije bioavailable ya aside folike na 5-MTHF ku bagore bazima.Yasanze 5-MTHF yarinjiye vuba kandi biganisha kuri folate nyinshi mu maraso atukura.
Kunoza imiterere ya folate:Ubushakashatsi bwinshi bwerekanye ko kuzuza 5-MTHF bishobora kongera urugero rwa folate.Mu igeragezwa ryateguwe ryasohotse mu kinyamakuru cy’imirire, abashakashatsi bagereranije ingaruka ziterwa na 5-MTHF hamwe na aside folike yiyongera ku miterere ya folate ku bagore bafite ubuzima bwiza.Basanze 5-MTHF yagize uruhare runini mu kongera urugero rwamaraso atukura ya folate kurusha aside folike.
Kongera imbaraga za aside folike metabolism:5-MTHF yerekanwe kurenga ku ntambwe ya enzymatique isabwa kugirango aside folike ikorwe kandi igire uruhare rutaziguye muri metabolisme ya selile.Ubushakashatsi bwasohotse mu kinyamakuru cyitwa Nutrition and Metabolism bwerekanye ko inyongera ya 5-MTHF yazamuye metabolisme yo mu bwoko bwa folate metabolisme ku bantu bafite ihindagurika ry’imiterere y’imisemburo igira uruhare mu gukora aside folike.
Kugabanya urwego rwa homocysteine:Urwego rwo hejuru rwa homocysteine, aside amine mu maraso, bifitanye isano no kongera ibyago byo kurwara umutima.Ubushakashatsi bwerekanye ko inyongera ya 5-MTHF ishobora kugabanya neza urugero rwa homocysteine.Isesengura rya meta ryasohotse mu kinyamakuru cyo muri Amerika College of Nutrition ryasesenguye ibigeragezo 29 byateganijwe kandi byanzura ko inyongera ya 5-MTHF yagize akamaro kuruta aside folike mu kugabanya urugero rwa homocysteine.
Ni ngombwa kumenya ko ibisubizo byabantu kugiti cyabo bishobora gutandukana, kandi imikorere ya 5-MTHF irashobora guterwa nimpamvu nkimiterere yimiterere yimiterere yimisemburo ya folate metabolism no gufata indyo yuzuye.Buri gihe birasabwa kugisha inama umuganga wubuzima kugirango agire inama yihariye yerekeye kongerwaho no kuganira kubibazo byihariye byubuzima.
