Kalisiyumu ya Methyltetrahydrofolate isukuye (5MTHF-Ca)
Methyltetrahydrofolate nziza Kalisiyumu (5-MTHF-Ca) ni ubwoko bwa folate buboneka cyane kandi bushobora gukoreshwa byoroshye n'umubiri. Ni umunyu wa kalisiyumu wa methyltetrahydrofolate, ari na wo utuma folate ikora mu mubiri. Folate ni vitamine B y'ingenzi igira uruhare runini mu mikorere itandukanye y'uturemangingo, harimo gukora ADN, gukora uturemangingo dutukura tw'amaraso, n'imikorere y'uturemangingo tw'imitsi.
MTHF-Ca ikunze gukoreshwa nk'inyongeramusaruro mu mirire kugira ngo ishyigikire urugero rwa folate ku bantu bashobora kugira ingorane mu gutunganya cyangwa kwinjiza aside folic iboneka mu biribwa bikungahaye ku ntungamubiri n'inyongeramusaruro. Ni ingirakamaro cyane cyane ku bantu bafite impinduka zimwe na zimwe mu ngirabuzimafatizo zishobora kwangiza imikorere ya folate.
Kongeraho MTHF-Ca bishobora gufasha mu kubungabunga ubuzima bwiza n'imibereho myiza muri rusange, cyane cyane mu nzego nko mu buzima bw'umutima n'imitsi, iterambere ry'imiyoboro y'ubwonko mu gihe cyo gutwita, imikorere y'ubwonko, no kugenzura uko amarangamutima ahagaze. Ni ngombwa kumenya ko MTHF-Ca ikwiye gukoreshwa iyobowe n'umuganga, cyane cyane ku bantu bafite indwara runaka cyangwa abafata imiti imwe n'imwe.
| Izina ry'igicuruzwa: | Kalisiyumu ya L-5-Methyltetrahydrofolate |
| Amagambo asa: | 6S-5-Methyltetrahydrofolate kalisiyumu; Kalisiyumu L-5-Methyltetrahydrofolate; Kalisiyumu ya Levomefolate |
| Formula ya Molecular: | C20H23CaN7O6 |
| Uburemere bwa molekile: | 497.52 |
| Nimero ya CAS: | 151533-22-1 |
| Ibikubiyemo: | ≥ 95.00% na HPLC |
| Ishusho: | Ifu y'umweru kugeza ku muhondo woroshye |
| Igihugu cy'inkomoko: | Ubushinwa |
| Pake: | 20kg/ingoma |
| Igihe cyo kubika: | Amezi 24 |
| Ububiko: | Bika ahantu hakonje kandi humutse. |
| Ibintu | Ibisobanuro | Ibisubizo |
| Isura | Ifu y'umweru cyangwa iy'umweru | Emeza |
| Indangamuntu | Ibyiza | Emeza |
| Kalisiyumu | 7.0%-8.5% | 8.4% |
| D-5-Methylfolate | ≤1.0 | Ntibyagaragaye |
| Ibisigazwa biri mu gutwika | ≤0.5% | 0.01% |
| Amazi | ≤17.0% | 13.5% |
| Isuzuma (HPLC) | 95.0%-102.0% | 99.5% |
| Ivu | ≤0.1% | 0.05% |
| Ibyuma bikomeye | ≤20 ppm | Emeza |
| Umubare wose w'amasahani | ≤1000cfu/g | Abafite Impamyabushobozi |
| Umusemburo n'Ibihumyo | ≤100cfu/g | Abafite Impamyabushobozi |
| E.coil | Ububi | Ububi |
| Salmonella | Ububi | Ububi |
Kuboneka cyane kw'ibinyabuzima:MTHF-Ca ni ubwoko bwa folate buboneka cyane mu mubiri, bivuze ko bushobora kwinjiza no gukoreshwa n'umubiri byoroshye. Ibi ni ingenzi kuko hari abantu bashobora kugira ikibazo cyo guhindura aside folic synthetic mu buryo bwayo bukora.
Ubwoko bw'umunyu wa folate:MTHF-Ca ni ubwoko bwa folate buzwi nka methyltetrahydrofolate. Ubu bwoko bukoreshwa byoroshye n'umubiri kandi ntibusaba ubundi buryo bwo guhindura.
Umunyu wa Kalisiyumu:MTHF-Ca ni umunyu wa kalisiyumu, bivuze ko ifitanye isano na kalisiyumu. Ibi bitanga inyungu yiyongereyeho yo kongeramo kalisiyumu hamwe n'inkunga ya folate. Kalisiyumu ni ingenzi ku buzima bw'amagufwa, imikorere y'imitsi, ihererekanya ry'imitsi, n'indi mirimo y'umubiri.
Bikwiriye abantu bafite itandukaniro ryihariye mu miterere y’uturemangingo:MTHF-Ca ni ingirakamaro cyane ku bantu bafite impinduka zimwe na zimwe mu ngirabuzimafatizo zishobora kwangiza imikorere ya folate. Izi mpinduka mu ngirabuzimafatizo zishobora kugira ingaruka ku bushobozi bw'umubiri bwo guhindura aside folic mu buryo bwayo bukora, bigatuma inyongera ya folate ikora iba ngombwa.
Ishyigikira ibintu bitandukanye by'ubuzima:Kongera MTHF-Ca bishobora gufasha ubuzima bwiza muri rusange. Ni ingirakamaro cyane cyane ku buzima bw'umutima n'imitsi, iterambere ry'imiyoboro y'ubwonko mu gihe cyo gutwita, imikorere y'ubwonko, no kugenzura uko umuntu yumva ameze.
Methyltetrahydrofolate Calcium (MTHF-Ca) itanga inyungu nyinshi ku buzima:
Inkunga y'ivuburwa rya folate:MTHF-Ca ni ubwoko bwa folate buboneka cyane kandi bukora. Ifasha mu gutera inkunga imikorere ya folate mu mubiri, ikaba ari ingenzi mu gukora ADN, gukora uturemangingo dutukura tw'amaraso, no gukora neza kw'uturemangingo muri rusange.
Ubuzima bw'umutima n'imitsi:Ingano ihagije ya folate ni ingenzi ku buzima bw'umutima n'imitsi. Kongera MTHF-Ca bishobora gufasha kugabanya urugero rwa homocysteine, aside amine, iyo ibaye nyinshi, ijyana n'ibyago byo kurwara indwara z'umutima n'imitsi.
Inkunga yo gutwita:MTHF-Ca ni ingenzi cyane mu gihe cyo gutwita, kuko ifasha mu gukumira ubusembwa bw'imiyoboro y'ubwonko mu nda zikiri nto. Abagore bageze mu kigero cyo kubyara ni byiza ko bagira urugero ruhagije rwa folate, cyane cyane mu gihe cyo gutwita.
Kugenzura uko amarangamutima ameze:Folate igira uruhare runini mu gukora neurotransmitters. Urugero ruhagije rwa folate rufasha mu gukora serotonin, dopamine, na norepinephrine, ibyo bikaba ari ingenzi mu kugenga ibyiyumvo. Kongera MTHF-Ca bishobora kuba ingirakamaro ku bantu bafite ibibazo by'imitekerereze, nko kwiheba.
Imikorere y'ubwenge:Folate ni ingenzi ku mikorere y'ubwonko no ku buzima bw'ubwonko. Kongera MTHF-Ca bishobora gufasha kwibuka, kwibanda ku bintu bifatika, no gukora neza mu bwenge muri rusange, cyane cyane ku bantu bakuze.
Inkunga y'imirire:Kongera MTHF-Ca bishobora kuba ingirakamaro ku bantu bafite impinduka mu miterere y’uturemangingo zigira ingaruka ku mikorere ya folate. Aba bantu bashobora kugira ingorane mu guhindura aside folic synthetic mu buryo bwayo bukora. MTHF-Ca itanga ubwoko bwa folate bukora mu buryo butaziguye, yirinda ibibazo byose byo guhindura.
Intungamubiri n'inyongeramusaruro mu mirire:MTHF-Ca ikunze gukoreshwa nk'ikintu cy'ingenzi mu ntungamubiri n'ibikomoka ku ntungamubiri. Itanga ubwoko bwa folate buboneka cyane, butanga inyungu nyinshi ku buzima, nk'uko byavuzwe mbere.
Kongera ibiryo n'ibinyobwa:MTHF-Ca ishobora gushyirwa mu biribwa n'ibinyobwa kugira ngo ikomeze folate. Ibi ni ingenzi cyane cyane ku bicuruzwa bifasha abantu bafite ikibazo cy'ibura rya folate cyangwa ibura ryinshi rya folate, nk'abagore batwite cyangwa abantu bafite indwara zimwe na zimwe.
Imiti: Imiti:MTHF-Ca ishobora gukoreshwa mu miti nk'ikintu gikora. Ishobora gukoreshwa mu miti yibanda ku ndwara zihariye zijyanye no kubura folate cyangwa imikorere mibi ya folate, nko kubura amaraso cyangwa indwara zimwe na zimwe ziterwa n'uturemangingo.
Kwita ku mubiri no kwisiga:MTHF-Ca rimwe na rimwe iboneka mu bikoresho byo kwisiga no mu mavuta yo kwisiga bitewe n'inyungu zayo ku buzima bw'uruhu. Folate igira uruhare mu mikorere itandukanye y'uturemangingo tw'uruhu kandi ishobora kugira uruhare mu buzima bwarwo muri rusange no ku isura yarwo.
Ibiryo by'amatungo:MTHF-Ca ishobora kandi gushyirwa mu biryo by'amatungo kugira ngo yongere folate ku matungo. Ibi ni ingenzi cyane ku matungo n'inkoko, aho kugira ngo habeho imirire ihagije kugira ngo habeho gukura no kugira ubuzima bwiza ari ngombwa.
Izi ngingo zigaragaza uburyo MTHF-Ca ikoreshwa mu buryo butandukanye n'uburyo ishobora gukoreshwa mu nganda zitandukanye mu gukemura ibibazo by'ubuzima bifitanye isano na folate n'ibikenewe mu mirire. Ariko, ni ngombwa gukurikiza amabwiriza akwiye yo gupima no kugisha inama abahanga mu bijyanye no gushyira MTHF-Ca mu gicuruzwa icyo ari cyo cyose cyangwa mu buryo ubwo aribwo bwose.
Gushaka ibikoresho fatizo:Iyi gahunda itangirira ku gushaka ibikoresho fatizo byiza cyane. Ibikoresho fatizo by'ibanze bikenewe kugira ngo MTHF-Ca ikoreshwe ni aside folike n'umunyu wa kalisiyumu.
Guhindura aside folike ikagera kuri 5,10-Methylenetetrahydrofolate (5,10-MTHF):Aside folike ihindurwamo 5,10-MTHF binyuze mu nzira yo kugabanya. Iyi ntambwe ikunze gukoreshwa mu gukoresha ibintu bigabanya nk'umusemburo wa sodium borohydride cyangwa ibindi bintu bikoreshwa mu kugabanya ubushyuhe.
Guhindura 5,10-MTHF muri MTHF-Ca:Ingano ya 5,10-MTHF iterwa kandi n'umunyu wa kalisiyumu ukwiye, nka kalisiyumu hidroksidi cyangwa karubone karubone, kugira ngo hakorwe Methyltetrahydrofolate Kalisiyumu (MTHF-Ca). Iyi nzira ikubiyemo kuvanga ibitera imbaraga no kubireka bigakorwa mu bihe bigenzurwa, harimo ubushyuhe, pH, n'igihe cyo gukora.
Gusukura no kuyungurura:Nyuma yo gukora isuzuma, umuti wa MTHF-Ca ukorerwa isuzuma nko kuyungurura, gupima, cyangwa ubundi buryo bwo gutandukanya kugira ngo ukureho imyanda n'ibindi bishobora kuba byarabayeho mu gihe cyo gukora isuzuma.
Kumisha no gukomera:Hanyuma umuti wa MTHF-Ca usukuye urushaho gutunganywa kugira ngo ukureho ubushuhe bwinshi no gukomeza umusaruro wa nyuma. Ibi bishobora kugerwaho hakoreshejwe uburyo nko kumisha cyangwa gukonjesha, bitewe n'ubwoko bw'umusaruro wifuza.
Igenzura ry'ubuziranenge n'ibizamini:Igicuruzwa cya nyuma cya MTHF-Ca gifatwa ingamba zikomeye zo kugenzura ubuziranenge kugira ngo kibe cyiza, gihamye, kandi kigenzurwe n'amahame y'ubuziranenge yagenwe. Ibi bishobora kuba birimo gupima imyanda, imbaraga, n'ibindi bipimo bifatika.
Gupakira no kubika:MTHF-Ca ipfunyikwa mu bikoresho bikwiye, bigatuma ibirango byayo bishyirwa neza kandi bikabikwa neza kugira ngo ikomeze kuba nziza kandi ihamye. Ubusanzwe ibikwa ahantu humutse kandi hakonje kure y'izuba ryinshi.
Kubika: Bika ahantu hakonje, humutse kandi hasukuye, Urinde ubushuhe n'urumuri rutaziguye.
Ipaki nini: 25kg/ingoma.
Igihe cyo gutanga serivisi: Iminsi 7 nyuma yo gutumiza.
Igihe cyo kuruhuka: Imyaka 2.
Icyitonderwa: Ibisobanuro byihariye nabyo birashobora kugerwaho.
20kg/umufuka 500kg/paleti
Gupfunyika by'imbaraga
Umutekano w'ibikoresho
Ikoranabuhanga rigezweho
munsi ya 100kg, iminsi 3-5
Serivisi yo ku nzu n'inzu biroroshye gufata ibicuruzwa
Ku nkengero z'inyanja
Birenze 300kg, hafi iminsi 30
Hakenewe umuhuzabikorwa w'inzobere mu gutanga serivisi zo ku cyambu uvuye ku cyambu
Mu ndege
100kg-1000kg, iminsi 5-7
Hakenewe umuhuzabikorwa w'inzobere mu gutanga serivisi zo ku kibuga cy'indege kuva ku kibuga cy'indege kugeza ku kibuga cy'indege
Kalisiyumu ya Methyltetrahydrofolate isukuye (5-MTHF-Ca)yemejwe ko afite icyemezo cya ISO, icyemezo cya HALAL, n'icyemezo cya KOSHER.
Itandukaniro riri hagati y’icyiciro cya kane cya aside folike (5-MTHF) na aside folike gakondo riri mu miterere yabyo n’uburyo biyoroheye umubiri.
Imiterere y'ibinyabutabire:Aside folike gakondo ni ubwoko bwa folike bukozwe mu buryo bwa sintetike bugomba kunyura mu ntambwe nyinshi mu mubiri mbere yuko bukoreshwa. Ku rundi ruhande, aside folike yo mu gisekuru cya kane, izwi kandi nka 5-MTHF cyangwa Methyltetrahydrofolate, ni ubwoko bwa folike bukora kandi buboneka mu mubiri kandi budasaba guhinduka.
Kuboneka kw'ibinyabuzima:Aside folike gakondo igomba guhindurwa ikaba imikorere yayo, 5-MTHF, binyuze mu bikorwa bya enzyme mu mubiri. Iyi nzira yo guhindura ihinduka iratandukanye bitewe n'abantu kandi ishobora guterwa n'impinduka mu ngirabuzimafatizo cyangwa izindi mpamvu. Mu buryo bunyuranye, 5-MTHF isanzwe iri mu miterere yayo, bigatuma iboneka ku buryo bworoshye kugira ngo ifashishwe mu ngirabuzimafatizo.
Uburyo bwo kwinjiza no gukoresha:Kwinjira kwa aside folike gakondo biba mu mara mato, aho ikenera guhinduka ikajya mu buryo bukora hakoreshejwe enzyme dihydrofolate reductase (DHFR). Ariko, ubu buryo bwo guhindura ntabwo bukora neza kuri bamwe, bigatuma bioavailability iba nke. 5-MTHF, kuko ari yo ikora, umubiri uhita winjira kandi ukoreshwa, ukirengagiza inzira yo guhindura. Ibi bituma iba ubwoko bwiza ku bantu bafite imiterere itandukanye cyangwa indwara zigira ingaruka ku mikorere ya folike.
Imyitozo ngororamubiri ku bantu bamwe na bamwe:Bitewe n'itandukaniro mu kwinjiza no gukoresha, 5-MTHF ifatwa nk'ikwiriye cyane ku bantu bafite impinduka zimwe na zimwe mu ngirabuzimafatizo, nko guhinduka kwa gene ya MTHFR, bishobora kwangiza ihinduka rya aside folic mu buryo bwayo bukora. Kuri abo bantu, gukoresha 5-MTHF mu buryo butaziguye bishobora kwemeza urugero rwiza rwa folate mu mubiri no gushyigikira imikorere itandukanye y'ibinyabuzima.
Inyongera:Aside folike gakondo ikunze kuboneka mu nyongeramusaruro, mu biribwa bikungahaye ku ntungamubiri, no mu biribwa bitunganywa, kuko ihoraho kandi ihendutse kuyikora. Ariko, hari ikwirakwira ry’inyongeramusaruro za 5-MTHF zitanga imiterere ikora neza, ibi bikaba byagirira akamaro abantu bafite ikibazo cyo guhindura aside folike.
Ingaruka mbi za aside folike yo mu gisekuru cya kane (5-MTHF) muri rusange ni nkeya kandi ntizikabije, ariko ni ngombwa kumenya ingaruka zishobora kubaho:
Ubwivumbure:Kimwe n'inyongeramusaruro cyangwa imiti iyo ari yo yose, ingaruka z'ubwivumbure zirashoboka. Ibimenyetso bishobora kuba birimo kubyimba, kuribwa, kubyimba, kuzerera, cyangwa kugorwa no guhumeka. Niba ubonye kimwe muri ibi bimenyetso, shaka abaganga vuba.
Ibibazo by'igogora:Hari abantu bashobora kugira ibibazo byo mu gifu, nko kugira isesemi, kubyimba, umwuka cyangwa impiswi. Ibi bimenyetso akenshi biba iby'igihe gito kandi bigashira uko umubiri umenyera inyunganizi.
Imikoranire n'imiti:5-MTHF ishobora kugira ingaruka ku miti imwe n'imwe, harimo imiti ikoreshwa mu kuvura kanseri, imiti igabanya ububabare, methotrexate, na antibiyotike zimwe na zimwe. Ni ngombwa kuvugana n'umuganga wawe niba ufata imiti iyo ari yo yose kugira ngo umenye neza ko nta ngaruka zishobora kubaho.
Kurenza urugero cyangwa urugero rw'ibinure bya folate:Nubwo kurya folate cyane (harimo na 5-MTHF) bishobora gutuma folate igabanuka mu maraso. Ibi bishobora guhisha ibimenyetso byo kubura vitamine B12 no kugira ingaruka ku ndwara zimwe na zimwe. Ni ngombwa gukurikiza urugero rwatanzwe no kugisha inama abaganga kugira ngo baguhe ubuyobozi.
Ibindi byo kwitabwaho:Abagore batwite cyangwa abateganya gutwita bagomba kuganiriza abaganga babo mbere yo gufata doze nyinshi ya 5-MTHF, kuko gufata folate nyinshi bishobora guhisha ibimenyetso byo kubura vitamine B12, ari ingenzi mu mikurire y'imiyoboro y'ubwonko mu mwana uri mu nda.
Nkuko bimeze ku nyongeramusaruro cyangwa imiti iyo ari yo yose, ni ngombwa kuganira n'umuganga ku ikoreshwa rya aside folike yo mu gisekuru cya kane (5-MTHF), cyane cyane niba ufite ibibazo by'ubuzima cyangwa urimo gufata indi miti. Bashobora kuguha inama ku giti cyawe bitewe n'ibyo ukeneye no kugufasha gukurikirana ingaruka zishobora kubaho.
Aside folike yo mu gisekuru cya kane, izwi kandi nka 5-methyltetrahydrofolate (5-MTHF), ni ubwoko bwa folike bukora neza mu mubiri kandi umubiri uhita winjizwa kandi ugakoresha neza ugereranije n’inyongera ya aside folike isanzwe. Dore bimwe mu bushakashatsi bwa siyansi bushyigikira imikorere yayo:
Kongera ubushobozi bwo kuboneka kw'ibinyabuzima:Byagaragaye ko 5-MTHF ifite ubushobozi bwo kuboneka mu mubiri kurusha aside folike. Ubushakashatsi bwasohotse mu kinyamakuru American Journal of Clinical Nutrition bwagereranije ubushobozi bwo kuboneka mu mubiri bwa aside folike na 5-MTHF ku bagore bazima. Bwagaragaje ko 5-MTHF yinjizwa vuba kandi bigatuma urugero rwa folike mu turemangingo dutukura tw’amaraso ruzamuka.
Imiterere ya folate yarushijeho kuba myiza:Ubushakashatsi bwinshi bwagaragaje ko kongera 5-MTHF bishobora kongera urugero rwa folate mu maraso. Mu igerageza ryakozwe ku buryo butaziguye ryasohotse mu kinyamakuru Journal of Nutrition, abashakashatsi bagereranije ingaruka zo kongera 5-MTHF na aside folic ku bagore bafite ubuzima bwiza. Basanze 5-MTHF ifite akamaro kanini mu kongera urugero rwa folate mu maraso kurusha aside folic.
Kongera imikorere y'aside folike:Byagaragaye ko 5-MTHF inyuranya n’intambwe za enzyme zisabwa kugira ngo aside folike ikoreshwe kandi ikagira uruhare mu buryo butaziguye mu mikorere y’uturemangingo twa aside folike. Ubushakashatsi bwasohotse mu kinyamakuru Journal of Nutrition and Metabolism bwagaragaje ko kongerera 5-MTHF bifasha mu mikorere y’uturemangingo twa folike mu bantu bafite impinduka mu miterere y’uturemangingo mu mikorere y’uturemangingo.
Kugabanuka k'urugero rwa homocysteine:Ingano iri hejuru ya homocysteine, aside amine iri mu maraso, ifitanye isano no kwiyongera k'ibyago byo kurwara indwara z'umutima n'imitsi. Ubushakashatsi bwagaragaje ko inyunganizi ya 5-MTHF ishobora kugabanya neza urugero rwa homocysteine. Isesengura ryasohotse mu kinyamakuru cya American College of Nutrition ryasesenguye igerageza 29 ryagenzuwe ku buryo butaziguye maze ryemeza ko inyunganizi ya 5-MTHF yari nziza kurusha aside folike mu kugabanya urugero rwa homocysteine.
Ni ngombwa kumenya ko uburyo umuntu yitabira inyunganizi zishobora gutandukana, kandi akamaro ka 5-MTHF gashobora guterwa n'ibintu nk'impinduka mu miterere y'uturemangingo mu misemburo ya folate metabolisme ndetse n'uburyo rusange bwo kurya. Buri gihe ni byiza kugisha inama umuganga kugira ngo akugire inama ku bijyanye n'inyongeramusaruro no kuganira ku bibazo cyangwa ibibazo byihariye by'ubuzima.
