Ifu nziza ya Rotundine (l-tetrahydropalmatine ， l-THP)

Rotundine, izwi kandi nka l-tetrahydropalmatine (l-THP), ni uruganda rufite imiti ya farumasi igira ingaruka ku mitsi yo hagati y’imitsi n’imitsi y’imitsi. Byaravuzwe ko bifite ingaruka zidasanzwe, zidahwitse, hypnotic, na anxiolytique. Byongeye kandi, byagaragaye ko bifite ingaruka zo gukingira ubwonko bwubwonko na myocardial ischemia-reperfusion. Rotundine izwi kandi ku bushobozi bwo guhindura imiti myinshi mu ngirabuzimafatizo za kanseri ndetse na calcium yo guhagarika imiyoboro ya calcium.
Irashobora kuboneka mubijumba bya Stephania tetrandra na Corydalis yanhusuo, cyangwa hakoreshejwe uburyo bwa synthesis. Gukomatanya kuva tetrahydropalmatine binyuze mukugabanya, clavage, na alkalisation reaction. Tetrahydropalmatine iyode irashobora gukomoka kuri tetrahydropalmatine binyuze muri alkalisation na okiside kugirango isubiremo.
Kuri farumasi, Rotundine yakirwa neza nyuma yubuyobozi bwo munwa kandi ikwirakwizwa cyane mubice bya adipose, bigakurikirwa nibihaha, umwijima, nimpyiko. Isohoka cyane binyuze mu mpyiko. Ubushakashatsi bwakozwe ku nzoka n'inkwavu bwerekanye ko Rotundine ishobora kwinjira mu nzitizi y'amaraso n'ubwonko ikinjira mu bwonko, ubwonko bukaba buri munsi y'amaraso nyuma y'amasaha 2.
Ku ngaruka mbi, Rotundine irashobora gutera gusinzira, kuzunguruka, umunaniro, isesemi, ndetse rimwe na rimwe bikagira allergie. Mu kwirinda harimo kwirinda gukoreshwa ku bagore batwite n'abonsa, kumenya ubushobozi bwo kwihanganirana no gukoresha igihe kirekire, no gukoresha ubwitonzi igihe ufatanije n’imitsi yo hagati y’imitsi y’imitsi, hamwe n’ibikenewe bikwiye.
Muri make, Rotundine nuruvange rufite ingaruka zitandukanye za farumasi, kandi imiterere yarwo ituma iba ikintu gishishikaje mubushakashatsi butandukanye, harimo gucunga ububabare, ubuzima bwimitsi yumutima, no kuvura kanseri. Kubindi bisobanuro hamagaragrace@biowaycn.com.