Ishusho y'ifu ya Sinomenine Hydrochloride

Ifu ya Sinominine Hydrochloride

Irwanya ububyimbirwe: Igabanya ububyimbirwe.
Igabanya ububabare: Itanga ububabare buhagije.
Igabanya ubudahangarwa bw'umubiri: Igabanya imikorere y'ubudahangarwa bw'umubiri.
Irwanya rubagimpande: Ivura rubagimpande.
Utunyangingo tw'ubwonko: Turinda uturemangingo tw'imitsi kwangirika.
Anti-fibrotic: Irinda cyangwa ikagabanya fibrosis y'ingingo.

Ohereza imeri kuri twe

Ibisobanuro birambuye ku gicuruzwa

Ibirango by'ibicuruzwa

Intangiriro y'ibicuruzwa

Sinomenine Hydrochloride ni ikinyabutabire gikomoka ku kimera cyitwa Sinomenium acutum, gikunze kuboneka muri Aziya y'Iburasirazuba. Ni alkaloid yakoreshejwe mu buvuzi bw'Abashinwa kubera ubushobozi bwayo bwo kurwanya ububyimbirwe no kugabanya ububabare. Ubwoko bwa hydrochloride ni umunyu wongera ubushobozi bwo gushonga no kudahungabana kw'ikinyabutabire, bigatuma kiba cyiza cyane mu buvuzi.
Sinomenine Hydrochloride yakozweho ubushakashatsi ku ngaruka zayo zishobora kuvura indwara nka rubagimpande, bitewe n'ubushobozi bwayo bwo guhindura ubudahangarwa bw'umubiri no kugabanya ububyimbirwe. Ikora mu kubuza ikorwa rya cytokine zitera ububyimbirwe n'izindi ngirabuzimafatizo zigize uruhare mu gusubiza ububyimbirwe.
Uretse ingaruka zayo zo kurwanya ububyimbirwe no kugabanya ububabare, Sinomenine Hydrochloride yagaragaje ko ishobora no kurinda ubwonko, kurwanya fibrosis, no kurwanya kanseri mu bushakashatsi butandukanye bwakozwe mbere yo kuvura.

Ibisobanuro

Izina ryemewe: (9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-morphinan-6-one, monohydrochloride
Nimero ya CAS: 6080-33-7
Inyito: Cucoline NSC 76021
Formula ya Molecular： C19H23NO4 • HCl
Uburemere bwa formula: 365.9
Ubuziranenge: ≥98% Igikomeye cya kristali
Gushonga (Menya ibijyanye n'ihindagurika ry'ishonga)
DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 5 mg/ml
PBS (pH 7.2): 5 mg/ml
Inkomoko ： Igiterwa / Sinomenium acutum
Amakuru yo Kohereza no Kubika:
Ububiko -20°C
Kohereza: Ubushyuhe bw'icyumba
Ituze: ≥ imyaka 4

Ikintu	Ibisobanuro	Ibisubizo
Isuzuma (HPLC)	98.0%	98.12%
Isura	Ifu y'umweru	Amategeko n'amabwiriza
Ingano y'uduce duto	98% kugeza kuri mesh 80	Amategeko n'amabwiriza
Impumuro mbi	Ibiranga	Amategeko n'amabwiriza
Uburyohe	Ibiranga	Amategeko n'amabwiriza
Imiterere y'umubiri
Igihombo mu kumisha	≤0.5%	0.38%
Ivu	≤0.5%	0.46%
Ibyuma biremereye
Ibyuma bikomeye (nk'uko Pb)	Ibipimo ngenderwaho bya USP (<10ppm)	<10ppm
Arsenic (As)	≤2ppm	0.78ppm
Imbere (Pb)	≤2ppm	1.13ppm
Kadiyumu (Cd)	≤lpm	0.36ppm
Mercary (Hg)	≤0.1ppm	0.01ppm
Ibisigazwa by'imiti yica udukoko	Ntibyagaragaye	Ntibyagaragaye
Umubare w'ibice byose	NMT 10000cfu/g	680 cfu/g
Umusemburo wose n'ibimera	NMT 100cfu/g	87 cfu/g
E.Coli	NMT 30cfu/g	10 cfu/g
Salmonella	Ububi	Ububi
Umwanzuro	Bijyanye n'amahame y'ikigo

Ibiranga

Ingaruka z'ingenzi za Sinomenine Hydrochloride zirimo:
(1) Irwanya ububyimbirwe: Igabanya ububyimbirwe.
(2) Igabanya ububabare: Itanga ububabare buhagije.
(3) Igabanya ubudahangarwa bw'umubiri: Igabanya imikorere y'ubudahangarwa bw'umubiri.
(4) Irwanya rubagimpande: Ivura rubagimpande.
(5) Kurinda ubwonko: Birinda uturemangingo tw'imitsi kwangirika.
(6) Kurwanya fibrosis: Birinda cyangwa bigabanya fibrosis y'ingingo.

Porogaramu

Sinomenine Hydrochloride ikoreshwa cyane cyane mu bice bikurikira:
(1) Ikigonderabuzima: Kuvura rubagimpande.
(2) Kurwanya ububabare: Kugabanya ububabare budakira.
(3) Kurwanya ububyimbirwe: Kugabanya ububyimbirwe.
(4) Guhindura ubudahangarwa bw'umubiri: Guhindura ubudahangarwa bw'umubiri.
(5) Uburinzi bw'imitsi: Bushobora gukoreshwa mu kuvura indwara z'imitsi.

Ibisobanuro by'umusaruro

Uburyo bwo gukora ifu ya Sinomenine Hydrochloride bushobora gusobanurwa muri make ku buryo bukurikira:

Gutegura ibimera:Gusukura no kumisha ibimera bibisi.
Gukuramo:Gukoresha imiti ishongesha nk'iya ethanol kugira ngo ukuremo sinomenine mu bimera.
Kwibanda ku bintu:Guhindura umwuka kugira ngo habeho sinomenine nyinshi.
Uburyo bwo guhuza alkali:Guhindura pH kugira ngo sinomenine ihinduke umunyu wayo.
Gukuramo amazi n'amazi:Gusukura hakoreshejwe imiti ikomoka ku bimera nka anisole cyangwa 1-heptanol.
Gukaraba:Gukaraba amazi kugira ngo bikureho imyanda n'ibisigazwa by'amazi.
Gutera aside:Kugabanya pH kugira ngo sinomine hydrochloride itere imbere.
Guhindura kristalo:Gukora kristu za sinominine hydrochloride.
Gutandukana:Gushyiramo ibyuma bivangura cyangwa kuyungurura kugira ngo bitandure kristu n'umuti.
Kumisha:Gukuraho ubushuhe busigaye mu ma kristu.
Gusya:Gusya kristu zumye zikavamo ifu nziza.
Kwibira:Kugenzura ko ingano y'uduce duto ikwirakwira kimwe.
Igenzura ry'Ubuziranenge:Gupima ubuziranenge, ukwishyira hamwe, n'ibipimo ngenderwaho bya mikorobe.
Gupfunyika:Ipakiye neza kandi ifunze neza kugira ngo ikwirakwizwe.

Gupakira no gutanga serivisi

Kubika: Bika ahantu hakonje, humutse kandi hasukuye, Urinde ubushuhe n'urumuri rutaziguye.
Ipaki nini: 25kg/ingoma.
Igihe cyo gutanga serivisi: Iminsi 7 nyuma yo gutumiza.
Igihe cyo kuruhuka: Imyaka 2.
Icyitonderwa: Ibisobanuro byihariye nabyo birashobora kugerwaho.

Uburyo bwo kwishyura no gutanga

Ikoranabuhanga rigezweho
munsi ya 100kg, iminsi 3-5
Serivisi yo ku nzu n'inzu biroroshye gufata ibicuruzwa

Ku nkengero z'inyanja
Birenze 300kg, hafi iminsi 30
Hakenewe umuhuzabikorwa w'inzobere mu gutanga serivisi zo ku cyambu uvuye ku cyambu

Mu ndege
100kg-1000kg, iminsi 5-7
Hakenewe umuhuzabikorwa w'inzobere mu gutanga serivisi zo ku kibuga cy'indege kuva ku kibuga cy'indege kugeza ku kibuga cy'indege