Lycorine Hydrochloride
Lycorine hydrochloride ni ifu y'umweru kuva kuri lycorine ikomoka kuri alkaloid, iboneka mu bimera bya Lycoris radiata (L'Her.), kandi iri mu muryango wa Amaryllidaceae. Lycorine hydrochloride ifite ingaruka zitandukanye zishobora guterwa n'imiti, harimo kurwanya ikibyimba, kanseri, HCV, kurwanya ubushyuhe, kurwanya bagiteri, kurwanya virusi, kurwanya angiogenesis, no kurwanya malariya. Irashongesha mu mazi, DMSO, na ethanol. Imiterere yayo ya shimi irangwa n'imiterere ikomeye ya steroidi ifite uburyohe busharira hamwe n'amatsinda menshi y'imikorere, harimo hydroxyl na amine, bigira uruhare mu bikorwa byayo by'ibinyabuzima.
| Izina ry'igicuruzwa | Lycorine hydrochloride CAS: 2188-68-3 | ||
| Isoko y'ibimera | Lycoris | ||
| Imiterere y'ububiko | Bika ahantu hapfundikiye ubushyuhe bw'icyumba | Itariki y'itangazo | 2024.08.24 |
| Ikintu | Igisanzwe | Ibisubizo |
| Ubwiza(cyangwa seHPLC) | Lycorine hydrochloride≥98% | 99.7% |
| Isura | Ifu y'umweru idakora neza | Bihuza |
| Imiterere y'umubiriics | ||
| Ingano y'uduce duto | NLT100% 80Umwobo | Bihuza |
| Igihombo ku kumisha | ≤1.0% | 1.8% |
| Biremereye icyuma | ||
| Ibyuma byose hamwe | ≤10.0ppm | Bihuza |
| Umuyobozi | ≤2.0ppm | Bihuza |
| Mercure | ≤1.0ppm | Bihuza |
| Kadimu | ≤0.5ppm | Bihuza |
| Udukoko duto | ||
| Umubare wose wa bagiteri | ≤1000cfu/g | Bihuza |
| Umusemburo | ≤100cfu/g | Bihuza |
| Escherichia coli | Ntabwo biri muri | Ntibyagaragaye |
| Salmonella | Ntabwo biri muri | Ntibyagaragaye |
| Stafilokokasi | Ntabwo biri muri | Ntibyagaragaye |
| Umwanzuro | Abafite Impamyabushobozi | |
Ibiranga:
(1) Ubwiza Buhanitse:Igicuruzwa cyacu gitunganywa neza kugira ngo gikoreshwe mu buryo bworoshye, ibyo bikaba ari ingenzi cyane kugira ngo gikore neza kandi gitekanye mu bikorwa bitandukanye.
(2) Imiterere yo kurwanya kanseri:Yagaragaje ingaruka zikomeye ku ndwara ya kanseri ku bwoko butandukanye bwa kanseri, haba mu buryo bwa vitro no mu buryo bwa vivo, binyuze mu buryo nko gutuma uruhererekane rw'uturemangingo ruhagarara, gutera apoptosis, no kubuza angiogenesis.
(3) Igikorwa cy’intego nyinshi:Bivugwa ko Lycorine hydrochloride ikorana n'ibintu byinshi bitera kanseri, bigatuma irushaho kugira ingaruka nziza ku turemangingo twa kanseri.
(4) Uburozi buke:Igaragaza uburozi buke ku turemangingo dusanzwe, ibyo bikaba ari ikintu cy'ingenzi mu ikoreshwa ryayo nk'umuti uvura.
(5) Imiterere y'imiti:Uyu muti wakoreweho ubushakashatsi ku bijyanye n'imiterere y'imiti, ugaragaza ko winjizwa vuba kandi uvanwa mu maraso vuba, ibyo bikaba ari ingenzi mu gutanga imiti no gutegura uburyo bwo kuvura.
(6) Ingaruka zihuriweho:Lycorine hydrochloride yagaragaje ingaruka nziza iyo ikoreshejwe hamwe n'indi miti, ibyo bikaba byagira akamaro mu kurwanya ubudahangarwa bw'imiti no kunoza umusaruro w'ubuvuzi.
(7) Ubushakashatsi bushyigikiwe:Iki gicuruzwa gishyigikiwe n'ubushakashatsi bwimbitse, butanga ishingiro rikomeye ryo gukoreshwa kwacyo mu guteza imbere imiti no mu buvuzi.
(8) Igenzura ry'ubuziranenge:Ingamba zikomeye zo kugenzura ubuziranenge zirakurikizwa mu gihe cyose cyo gukora kugira ngo habeho ubwumvikane n'ubudahemuka bw'umusaruro.
(9) Porogaramu zikoreshwa mu buryo butandukanye:Ikwiriye gukoreshwa mu bushakashatsi no mu iterambere ry'imiti, harimo kuvumbura imiti no guteza imbere uburyo bwo kuvura kanseri.
(10) Gukurikiza amategeko:Byakozwe hakurikijwe amabwiriza ya GMP kugira ngo bigenzure umutekano n'imikorere y'ibicuruzwa.
(1) Inganda zikora imiti:Lycorine hydrochloride ikoreshwa mu guteza imbere imiti irwanya kanseri n'imiti irwanya virusi.
(2) Inganda z'ikoranabuhanga:Ikoreshwa mu bushakashatsi no guteza imbere imiti mishya ivura n'imiti.
(3) Ubushakashatsi ku bicuruzwa karemano:Lycorine hydrochloride irasuzumwa ku nyungu zayo ku buzima n'imiti ishobora kuyivura.
(4) Inganda zikora imiti:Ishobora gukoreshwa nk'ikintu cy'ingenzi mu guhuza ibindi bintu.
(5) Inganda z'ubuhinzi:Lycorine hydrochloride yakozweho ubushakashatsi ku bushobozi bwayo nk'umuti urwanya udukoko n'imikurire y'ibimera karemano.
Uburyo bwo gukuramo lycorine hydrochloride busanzwe bukubiyemo intambwe z'ingenzi zikurikira kugira ngo umuti ugire isuku no kunoza igipimo cyo kugarura:
(1) Guhitamo no gutunganya ibikoresho mbere y'uko bikoreshwa:Hitamo ibikoresho fatizo by’ibimera bya Amaryllidaceae bikwiye, nk’utubuto twa Amaryllis, hanyuma ubisukemo amazi, ubihanagure kandi ubice kugira ngo urebe ko ibikoresho fatizo ari byiza kandi ushyireho urufatiro rwo kubikuramo nyuma.
(2)Uburyo bwo kuvura mbere y’uko enzyme ikorwa:Koresha enzymes zikomeye (nka cellulase na pectinase) kugira ngo uvure ibikoresho fatizo byasenyutse mbere yo kwangiza inkuta z'uturemangingo tw'ibimera no kunoza uburyo bwo kubikuramo nyuma.
(3)Kuramo aside hydrochloric leaching:Vanga ibikoresho fatizo byavuwe mbere n'umuti wa aside hydrochloric woroshye kugira ngo uvane lycorine. Gukoresha aside hydrochloric bifasha kongera ubushobozi bwo gushonga kwa lycorine, bityo bikanoza imikorere myiza yo kuyikuramo.
(4)Gukuramo hakoreshejwe ikoranabuhanga rigezweho:Gukoresha ikoranabuhanga ryo gukuramo ibintu hifashishijwe ikoranabuhanga rya ultrasonic bishobora kwihutisha inzira yo gushonga kwa lycorine mu kintu gishongesha ibintu kandi bikanoza imikorere myiza n'ubuziranenge bw'ibintu bishongesha ibintu.
(5)Gukuramo chloroform:Gukuramo ibintu bikorwa hifashishijwe imiti ikomoka ku bimera nka chloroform, maze lycorine ikava mu gice cy’amazi ijya mu gice cy’ibinyabuzima kugira ngo irusheho gusukura icyo kintu kigamije.
(6)Kugarura umuti ushongesha:Nyuma yo gukuramo, umuti uvanwa mu mwuka cyangwa mu gusya kugira ngo ugabanye ikoreshwa ry’umuti kandi wongere igiciro.
(7)Gusukura no kumisha:Binyuze mu nzira zikwiye zo gusukura no kumisha, ifu ya lycorine hydrochloride iboneka.
Mu gihe cyose cyo gukuramo amazi, kugenzura uburyo akoreshwa mu gukurura amazi, imiterere y’amazi akoreshwa mu gukurura amazi (nk’agaciro ka pH, ubushyuhe, n’igihe), hamwe n’intambwe zikurikiraho zo gutunganya amazi ni ingenzi mu kwemeza ko akoreshwa mu gukurura amazi no kunoza umuvuduko wo kuyagarura. Gukoresha ibikoresho bigezweho byo gukuramo amazi no kuyasukura, nka ultrasonic extractors na high-performance liquid chromatography (HPLC), nabyo bifasha kunoza imikorere myiza yo gukuramo amazi no kunoza ubwiza bw’ibicuruzwa.
Kubika: Bika ahantu hakonje, humutse kandi hasukuye, Urinde ubushuhe n'urumuri rutaziguye.
Ipaki nini: 25kg/ingoma.
Igihe cyo gutanga serivisi: Iminsi 7 nyuma yo gutumiza.
Igihe cyo kuruhuka: Imyaka 2.
Icyitonderwa: Ibisobanuro byihariye nabyo birashobora kugerwaho.
Ikoranabuhanga rigezweho
munsi ya 100kg, iminsi 3-5
Serivisi yo ku nzu n'inzu biroroshye gufata ibicuruzwa
Ku nkengero z'inyanja
Birenze 300kg, hafi iminsi 30
Hakenewe umuhuzabikorwa w'inzobere mu gutanga serivisi zo ku cyambu uvuye ku cyambu
Mu ndege
100kg-1000kg, iminsi 5-7
Hakenewe umuhuzabikorwa w'inzobere mu gutanga serivisi zo ku kibuga cy'indege kuva ku kibuga cy'indege kugeza ku kibuga cy'indege
Bioway Organic yabonye icyemezo cya USDA na EU organic, BRC, ISO, HALAL, KOSHER, na HACCP.
Lycorine ni alkaloid isanzwe iboneka mu bimera byinshi, cyane cyane mu muryango wa Amaryllidaceae. Dore bimwe mu bimera bizwiho kugira lycorine:
Lycoris radiata(izwi kandi nka lily y'umutuku cyangwa manjushage) ni ikimera gakondo cy'Abashinwa gikoreshwa mu kuvura kirimo lycorine.
Leucojum aestivum(urubura rwo mu mpeshyi), bizwi kandi ko birimo lycorine.
Ungernia sewertzowiini ikindi kimera cyo mu muryango wa Amaryllidaceae cyavuzwe ko kirimo lycorine.
Hippeastrum hybrid (Ilisi ya Pasika)n'ibindi bimera bifitanye isano na Amaryllidaceae ni isoko izwiho ya lycorine.
Ibi bimera bikwirakwira cyane mu turere dushyuha n’utwo mu turere dushyuha hirya no hino ku isi kandi bifite amateka maremare yo gukoreshwa mu buvuzi gakondo. Kuba lycorine iri muri ibi bimera byakorewe ubushakashatsi bitewe n’ubushobozi bwayo bwo mu rwego rw’imiti, harimo n’ingaruka zikomeye zo kurwanya kanseri nk’uko byagaragajwe mu bushakashatsi butandukanye.
Lycorine ni alkaloid karemano ifite ingaruka nyinshi mu buvuzi, harimo n'ikoreshwa ryayo mu kuvura kanseri. Nubwo yagaragaje ibisubizo byiza mu bushakashatsi butandukanye, hari ingaruka zimwe na zimwe zavuzwe n'ibintu bifitanye isano no kuyikoresha:
Uburozi buke: Lycorine n'umunyu wayo wa hydrochloride muri rusange bigaragaza uburozi buke, ibi bikaba ari umwihariko mwiza mu buvuzi. Byagaragaye ko igira ingaruka mbi nke ku turemangingo dusanzwe tw'umuntu n'imbeba nzima, bigaragaza ko hari urwego runaka rw'uburyo uturemangingo twa kanseri duhitamo uturemangingo dusanzwe.
Ingaruka z'igihe gito zo gushyuha: Isesemi no kuruka by'igihe gito byagaragaye nyuma yo guterwa lycorine hydrochloride mu jisho cyangwa mu mitsi, akenshi bigabanuka mu masaha 2.5 nta ngaruka zagize ku buzima bw'ibinyabutabire cyangwa imiterere y'amaraso.
Nta guhuza imiyoboro y'amaraso mu buryo butunguranye: Ubushakashatsi bwagaragaje ko dose ya lycorine idakora ku guhuza imiyoboro y'amaraso mu mbeba, nk'uko byagenzuwe n'ikizamini cya rotarod, bigaragaza ko idatera ingaruka mbi ku miyoboro y'amaraso yo mu mutwe (CNS) zijyanye no kugenzura imiyoboro y'amaraso.
Ingaruka ku bikorwa bya "Locomotor" bitunguranye: Ku gipimo cya 30 mg / kg, lycorine yagaragaye ko ibangamira imikorere ya "locomotor" mu mbeba, nk'uko bigaragazwa no kugabanuka k'imyitwarire yo kurera no kwiyongera k'ukudashobora kugenda.
Imyitwarire rusange n'imibereho myiza: Igipimo cya 10 mg / kg cya lycorine nticyagize ingaruka ku myitwarire rusange n'imibereho myiza y'imbeba, bigaragaza ko iki gipimo gishobora kuba cyiza mu isuzuma ry'imikorere y'ubuvuzi mu gihe kizaza.
Nta ngaruka mbi zikomeye ku buremere bw'umubiri cyangwa imiterere y'ubuzima: Gutanga lycorine na lycorine hydrochloride nta ngaruka mbi zagize ku buremere bw'umubiri cyangwa imiterere y'ubuzima muri rusange mu mbeba zifite ikibyimba.
Ni ngombwa kumenya ko nubwo lycorine yagaragaje ubushobozi mu bushakashatsi bwa mbere y’ubuvuzi, isuzuma ry’uburozi bw’igihe kirekire riracyari hasi. Hakenewe ubundi bushakashatsi kugira ngo dusobanukirwe neza imiterere y’umutekano wayo, cyane cyane iyo ikoreshwa igihe kirekire no mu buvuzi. Ingaruka mbi n’umutekano wa lycorine bishobora gutandukana bitewe n’ingano, uburyo itangwa, n’imiterere y’umurwayi ku giti cye. Buri gihe banza uganire n’umuganga w’inzobere mu by’ubuzima mbere yo gutekereza gukoresha inyongeramusaruro nshya cyangwa uburyo bwo kuvura.
