Umuyoboro mwiza wa methyltehyhfolate ya calcium (5hthf-ca)
Methyltetrahydrothelos Numunyu wa calcium ya methyltetrahydrofolate, nuburyo bukora bwa folate mumubiri. Folate ni vitamine y'ingenzi b igira uruhare runini mu nzira zitandukanye, harimo synthesis zitandukanye, umusaruro wamaraso utukura, umusaruro wamaraso, hamwe n'imikorere ya sisitemu y'imitsi.
Mthf-ca ikunze gukoreshwa nkinyongera yimirire kugirango ishyigikire urwego rwibitere imbere kubantu bashobora kugira ikibazo cyo kumenya cyangwa gukurura imiterere ya synthique ya aside folic habonetse ibiryo bikomeye hamwe nubwato. Ni ingirakamaro cyane kubantu bafite imiterere ya genetike ishobora kubangamira metabolism.
Guhura na Mthf-Ca birashobora gufasha gushyigikira ubuzima rusange ndetse numubiri, cyane cyane mubuzima bwamajipo, iterambere ryumutima, mugihe cyo gutwita, nimikorere yubwenge, no kuyobora. Ni ngombwa kumenya ko Mthf-Ca agomba gukoreshwa ayobowe numwuga wubuzima, cyane cyane kubantu bafite uburwayi bwihariye cyangwa abafata imiti imwe.
| Izina ry'ibicuruzwa: | L-5-methyltehyhyDolalate calcium |
| Synonyme: | 6S-5-methyltehyhfolate ya calcium; calcium l-5-methyltehyhyDofolate; jaomerafolate calcium |
| Formulare ya molecular: | C20H23CAN7O6 |
| Uburemere bwa molekile: | 497.52 |
| CAS NO: | 151533-22-1 |
| Ibirimo: | ≥ 95.00% by HPLC |
| Kugaragara: | Cyera kugeza urumuri rwumuhondo kuri kristu |
| IGIHUGU CY'INKOMOKO: | Ubushinwa |
| Ipaki: | 20Kg / ingoma |
| Ubuzima Bwiza: | Amezi 24 |
| Ububiko: | Komeza ahantu hakonje & humye. |
| Ibintu | Ibisobanuro | Ibisubizo |
| Isura | Ifu yera cyangwa yera | Kwemeza |
| Indangamuntu | Byiza | Kwemeza |
| Calcium | 7.0% -8.5% | 8.4% |
| D-5-methyfolate | ≤1.0 | Ntibimenyekana |
| Ibisigisigi | ≤0.5% | 0.01% |
| Amazi | ≤17.0% | 13.5% |
| Isuzuma (hplc) | 95.0% -102.0% | 99.5% |
| Ivu | ≤0.1% | 0.05% |
| Ibyuma biremereye | Ppm | Kwemeza |
| Ikibanza cyose cyo kubara | ≤1000cfu / g | Bujuje ibisabwa |
| Umusemburo & Mold | ≤100CFU / G. | Bujuje ibisabwa |
| E.coil | Bibi | Bibi |
| Salmonella | Bibi | Bibi |
BIOVAVAIILIYLIY:Mthf-ca ni uburyo bwibinyabuzima bugaragara bwa folate, bivuze ko ishobora kwishora byoroshye kandi ikoreshwa numubiri. Ibi ni ngombwa kuko abantu bamwe bashobora kuba bafite ikibazo cyo guhindura aside fornthetic acide muburyo bwacyo.
Ifishi ikora ya folate:Mthf-ca nuburyo bukora bwa folate, buzwi nka methyltehhyrofolate. Iyi fomu ikoreshwa byoroshye numubiri kandi ntabwo isaba inzira zose zo guhindura.
Umunyu wa Calcium:Mthf-ca ni umunyu wa calcium, bivuze ko zihambiriye calcium. Ibi bitanga inyungu ziyongereye zo kwiyongera kwa Kalisi hamwe ninkunga ya Litelate. Calcium ni ngombwa mu buzima bwamagufwa, imikorere yimitsi, kohereza imitsi, nibindi bikorwa byumubiri.
Bikwiranye nabantu bafite ubwoko bwihariye bwa genetike:Mthf-Ca ni ingirakamaro cyane kubantu bafite imiterere ya genetike ishobora kubangamira metabolism. Ibi bitandukanya genetike birashobora kugira ingaruka kubushobozi bwumubiri bwo guhindura aside folic muburyo bwayo, bigatuma ari folate ikora ikenewe.
Shyigikira ibintu bitandukanye by'ubuzima:Inyongera ya Mthf-Cu irashobora gushyigikira ubuzima rusange n'imibereho myiza. Ni ingirakamaro cyane cyane kubuzima bwumubiri, iterambere rya neire tube mugihe batwite, imikorere yubwenge, hamwe namategeko ava.
Methyltetrahyhfolate ya Calcium (Mthf-ca) itanga inyungu nyinshi zubuzima:
Folate metabolism ishyigikiye:Mthf-ca ni ibintu biboneka cyane kandi bifite ishusho ya folate. Ifasha gushyigikira folate yumubiri metabolism, ingenzi kuri synthesis ya ADN, umusaruro wamaraso utukura, kandi imikorere ya selile.
Ubuzima bw'imitima:Urwego ruhagije rwingenzi ningirakamaro kubuzima bwumutima. Inyongera ya Mthf-Cubake zirashobora kugabanya urwego rwa homocysteine, acide amino ibyo, ubwo byazamuwe, bifitanye isano no guhura numutima wumutima.
Inkunga yo gutwita:Mthf-ca ningirakamaro mugihe utwite, kuko bifasha gukumira inenge zubuhanga mugutezimbere. Birasabwa kubagore bafite imyaka yo kubyara kugirango barebe ko bafite urwego ruhagije rwa folate, cyane cyane mugihe cyibanze cyo gutwita.
Amabwiriza meza:Folate igira uruhare rukomeye muri synthesis. Urwego ruhagije rushyigikira umusaruro wa Serotonine, Dopamine, na Norepinephrine, ari ngombwa mu mategeko meza. Kwiyongera kwa Mthf-Cu birashobora kuba ingirakamaro kubantu bafite ubumuga bwo kutabona, nko kwiheba.
Imikorere yo kumenya:Folate ni ngombwa mu mikorere yo kumenya n'ubwonko. Inyongera ya Mthf-Ca irashobora gushyigikira kwibuka, kwibanda, nuburyo imikorere yubwenge rusange, cyane cyane mubakuze.
Inkunga y'imirire:Indwara ya Mthf-Cu ingirakamaro kubantu bafite imiterere ya genetike igira ingaruka kuri metabolism. Aba bantu barashobora kugira ikibazo cyo guhindura aside fornthetique muburyo bwacyo. MTHF-CA itanga uburyo bukora bwa folate butaziguye, izenguruka ibibazo byose.
Nutraceuticals ningendo zimirire:Mthf-ca akunze gukoreshwa nkibyingenzi muburyo bwimirire nuburato. Itanga uburyo bwibinyabuzima bugaragara bwa folate, butanga inyungu zubuzima, nkuko byavuzwe haruguru.
Ibiryo n'ibinyobwa:Mthf-ca irashobora kwinjizwa mubiryo n'ibinyobwa kugirango bikomeze na folate. Ibi ni ngombwa cyane cyane kubicuruzwa bitagukana abaturage hamwe no gutandukanya cyangwa kwiyongera gukurikiza ibikenewe, nkabagore batwite cyangwa abantu bafite ubuzima runaka.
Ibikorwa bya farumasi:Mthf-ca irashobora gukoreshwa muri farumasi yibikoresho nkibikorwa bikora. Irashobora gukoreshwa mumiti yibasiye ibintu byihariye bijyanye no kubura kubura cyangwa kubangamira induru metabolism, nka anemia cyangwa indwara za genetiya.
Kwitaho kugiti cyawe no kwisiga:MTHF-CA rimwe na rimwe ishyirwa mubicuruzwa byita kugiti cyawe no kwisiga kubera inyungu zayo zishoboka kubuzima bwuruhu. Folate igira uruhare mubikorwa bitandukanye byuruhu kandi bishobora kugira uruhare mubuzima bwacyo no kugaragara.
Kugaburira amatungo:Mthf-ca irashobora kandi kwinjizwa kubiryo byinyamanswa kugirango byuzuze inyamaswa. Ibi birakenewe cyane cyane amatungo n'inganda zikositimu, aho kwemeza imirire ihagije yo gukura no kubaho ari ngombwa.
Ibi bisabwa bigaragaza uburyo bwa Mthf-ca kandi ishobora gukoresha munganda zitandukanye kugirango ikemure ibibazo byubuzima bifatika hamwe nibikenewe byimirire. Ariko, ni ngombwa gukurikiza umurongo ngenderwaho ukwiye kandi ugisha inama abanyamwuga mugihe ushyiramo Mthf-ca mubicuruzwa byose cyangwa formulate.
Gutesha agaciro ibikoresho fatizo:Inzira itangirana no gutorebanya ibikoresho byibanze. Ibikoresho byibanze byibanze kugirango umusaruro wa Mthf-ca ni aside folike na calcium.
Guhindura aside folike kuri 5,10-methylenetetrahydhfolate (5,10-Mthf):Acide folike yahinduwe muri 5,10-Mthf binyuze muburyo bwo kugabanya. Iyi ntambwe ikubiyemo gukoresha abakozi kugabanya nka sodium borohydride cyangwa undi museke ukwiye.
Guhindura 5,10-Mthf kuri Mthf-ca:5,10-mthf yongeye gutwarwa numunyu ubereye calcium, nka calcium hydroxide cyangwa calcium carboum, kugirango ikore methyltehyhfolate calcium (Mthf-ca). Iyi nzira ikubiyemo kuvanga reaction no kubemerera kubyitwaramo kugenzurwa, harimo ubushyuhe, PH, n'ibihe.
Gusunika no kugisimba:Nyuma yibyo, igisubizo cya Mthf-ca yo kwezwa nka cyuma, centrifugation, cyangwa ubundi buryo bwo gutandukana kugirango bakureho umwanda nibibi nibicuruzwa bishobora kuba byarakozwe mugihe cyimyitwarire.
Kuma no gukomera:Igisubizo cya Mthf-cha-ca noneho gitunganizwa kugirango ukureho ubushuhe burenze kandi dushimangira ibicuruzwa byanyuma. Ibi birashobora kugerwaho binyuze muburyo bwo gukanda cyangwa gukonjesha-byumye, bitewe nuburyo bwibicuruzwa byifuzwa.
Kugenzura ubuziranenge no kwipimisha:Ibicuruzwa byanyuma bya Mthf-ca bikoreshwa neza uburyo bukomeye bwo kugenzura kugirango tubunganire, gushikama, no kubahiriza ibipimo ngenderwaho byagenwe. Ibi birashobora kubamo kugerageza umwanda, imbaraga, nibindi bipimo bireba.
Gupakira no kubika:Mthf-ca yapakiwe mubintu bibereye, kugirango akemure ikirango aboneye nububiko kugirango akomeze ubunyangamugayo no gutuza. Mubisanzwe bibikwa mumwanya wumye, ukonje kure yumucyo wizuba.
Ububiko: Gumana ahantu hakonje, byumye, kandi usukuye, urinde umucyo kandi utaziguye.
Paki nyinshi: 25Kg / ingoma.
Kugeza igihe: Iminsi 7 nyuma yo gutumiza kwawe.
Ubuzima bwa Shelf: imyaka 2.
Ijambo: Ibisobanuro byateganijwe nabyo birashobora kugerwaho.
20Kg / Umufuka 5KG / Pallet
Gupakira
Umutekano wa logistique
Express
Munsi ya 100kg, 3-5 iminsi
Umuryango wa serivisi yumuryango byoroshye gufata ibicuruzwa
Inyanja
Hejuru300KG, hafi iminsi 30
Icyambu cya serivisi ya Port wabigize umwuga Broker birakenewe
N'umwuka
100kg-1000kg, 5-7 iminsi
Ikibuga cy'indege cya serivisi yikibuga cya serivisi Umunyabwenge Birakenewe
Igihombo cya methyltehyhfolate ya calcium (5-mthf-ca)byemejwe hamwe nicyemezo cyi iso, icyemezo cya Halal, hamwe na kosher icyemezo.
Itandukaniro riri hagati yigisekuru cya kane cya acide folike (5-mthf) na aside ya folike iryamye mumiterere yabo ya shimi hamwe numubiri.
Imiterere yimiti:Ubukorikori bwa folike nuburyo bwa sinthetike ya folate bukeneye guhindukira intambwe nyinshi zo guhindura mumubiri mbere yuko rikoreshwa. Kurundi ruhande, igisekuru cya kane cya folike, kizwi kandi nka 5-mthytehyhydrofolate, nuburyo bukora bwa folate budasaba guhinduka.
BIOAVIAILAVATION:Acide gakondo ya folike akeneye guhindurwa muburyo bwacyo, 5-mthf, binyuze muburyo bwiza bwo mu mubiri. Iyi nzira yo guhindura iratandukanye kubantu kandi irashobora guterwa na genetic itandukaniro cyangwa ibindi bintu. Ibinyuranye, 5-MTHF isanzwe muburyo bwayo, bigatuma byoroshye kuboneka kwa seldoulaline no gukoresha neza.
Kwinjira no gukoresha:Kwinjiza aside gakondo ya folike bibaho mumara mato, aho bikeneye guhinduka muburyo bukora bwa enzyme diyctase yo kugabanya imirongo (DHFR). Ariko, iyi nzira yo guhindura ntabwo ikora neza kubantu bamwe, biganisha kuri biowaiaveuility. 5-Mthf, kuba ifishi ikora, yahise yinjira kandi ikoreshwa numubiri, ishira inzira yo guhinduka. Ibi bituma habaho uburyo bwatoranijwe kubantu bafite imiterere ya genetique cyangwa ibintu bigira ingaruka kuri folate metabolism.
Fitness kubantu bamwe:Kubera itandukaniro ryinjira no gukoresha, 5-MTHF ifatwa nkaho ikwiranye nabantu bamwe batandukana na moneti, nka mthr gene, ishobora kubangamira ihinduka rya folic aside foid. Kuri abo bantu, bakoresheje MTHF 5 mu buryo butaziguye barashobora kwemeza urwego rukwiye mu mubiri no gushyigikira imirimo itandukanye y'ibinyabuzima.
INKINGI:Acide gakondo ya folike akunze kuboneka munyongera, ibiryo bikomejwe, nibiryo byatunganijwe, nkuko bihamye kandi bidahenze kubyara. Ariko, hari kuboneka kwiyongera kwunyongera 5-MTHF bitanga uburyo bukora muburyo butaziguye, bushobora kuba ingirakamaro kubantu bafite ikibazo cyo guhindura aside folike.
Ingaruka zo kuruhande rwamagana-acide ya folike (5-Mthf) muri rusange ni gake kandi witonda, ariko ni ngombwa kumenya ibitekerezo bishobora kuba:
Ibisubizo bya Allergic:Nk'inyongera cyangwa imiti, reactions allergique birashoboka. Ibimenyetso bishobora kuba birimo guhubuka, kunaniza, kubyimba, kuzunguruka, cyangwa guhumeka. Niba hari icyo ubona muri ibyo bimenyetso, shakisha ubuvuzi bwihuse.
Ibibazo by'igikoresho:Abantu bamwe barashobora guhura na Distrointestisal, nka Nasesea, babyimba, gaze, cyangwa impiswi. Ibi bimenyetso mubisanzwe byigihe gito kandi bigabanuka nkuko umubiri umenya inyongera.
Imikoranire n'imiti:5-MTHF irashobora gukorana n'imiti imwe n'imwe, harimo imiti ikoreshwa mu kuvura kanseri, anticonvulisants, uburyo, na antibiyotike zimwe. Ni ngombwa kuvugana nuwatanze ubuzima niba urimo gufata imiti kugirango utange imikoranire ishobora.
Kurenza urugero cyangwa birenze urugero:Mugihe udasanzwe, gufata cyane kuri folate (harimo 5-mthf) birashobora kuganisha ku nshuro maremare ya maraso ya folate. Ibi birashobora guhisha ibimenyetso bya vitamine B12 kandi bigira ingaruka kubijyanye no gusuzuma no kuvura ibintu bimwe. Ni ngombwa gukurikiza dosiye isabwa no kubaza inzobere mu buzima bwo kuyobora.
Ibindi Bwibitekerezo:Abagore batwite cyangwa abateganya gutwita bagomba kuvugana n'abashinzwe ubuzima mbere yo gufata dosiye nyinshi za 5-Mthf, nk'ibyinshi cyane ku rukebe rw'ibisobanuro bya Vitamine.
Nko hamwe ninyongera yimirire cyangwa imiti, birakenewe kuganira kubijyanye no gukoresha ibisekuruza bya folike-5-MTHF hamwe nuwatanze ubuzima, cyane cyane niba ufite ubuzima bwubuzima bwibanze cyangwa ufata indi miti. Barashobora gutanga inama zihariye zishingiye kubyo ukeneye byihariye kandi bifasha gukurikirana ingaruka zose zishoboka.
Igisekuru cya kane cya folike, kizwi kandi nka methyltehyhfolate (5-mthf), ni uburyo bukora bwibinyabuzima bwa folate byoroshye gufatwa kandi bikoreshwa numubiri ugereranije ninyongera gakondo. Hano hari ubushakashatsi bwa siyansi bushyigikira imikorere yacyo:
Kwiyongera BiriowaiLALALATIVE:5-MTHF yerekanwe kugira ibinyabuzima bikabije kuruta aside folike. Ubushakashatsi bwasohotse mu kinyamakuru cy'Abanyamerika cy'imirire y'amavuriro ugereranije na bioakaiaility ya acide ya folike na 5-mthf mu bagore bazima. Yasanze 5-Mthf yakiriwe vuba kandi igayobora ku rwego rwo hejuru muri selile zitukura.
Ibyiza bya folateUbushakashatsi bwinshi bwerekanye ko kuzuzanya hamwe na 5-MTHF bishobora kongera neza inzego. Mu rubanza rugenzurwa ruteganijwe rwatangajwe mu kinyamakuru cy'imirire, abashakashatsi bagereranije ingaruka za 5-mthf na folike acide acide ku nkombe za folate mu bagore bafite ubuzima bwiza. Basanze 5-Mthf yari ifite akamaro mu kongera urwego rwamaraso atukura kuruta aside folike.
Kuzamura metabolism folic:5-Mthf yerekanwe kurenga intambwe enye zisabwa kugirango zikore folike acd kandi zigire uruhare mu buryo butaziguye muri metaboliaction ya FOLC. Ubushakashatsi bwasohotse mu kinyamakuru cy'imirire na Metabolism bwerekanye ko inyongera 5 z'amashuri 5 yotthf yateje imbere imashini itembera mu miterere ku giti cye hamwe na enzymes mu bikorwa bya FOLCMEs.
Kugabanya urwego rwa homocsteine:Urwego rwo hejuru rwa Homocysteine, aside amino mu maraso, ifitanye isano no guhura n'indwara z'umutima. Ubushakashatsi bwerekanye ko ishuri rya 5-MTHF rirashobora kugabanya neza urwego rwa homocsteine. Meta-Isesengura ryatangajwe mu kinyamakuru Ishuri Rikuru ry'Abanyamerika ryasesenguwe 29 ryakozwe ku bigeragezo bigenzurwa maze rinzura ko inyongera 5 yo korezo rya Flic mu kugabanya incide ya homocsteine.
Ni ngombwa kumenya ko ibisubizo byihariye byo kwiyongera bishobora gutandukana, kandi imikorere ya 5-MTHF irashobora guterwa mubintu nkibitandukanye bya felate muri folate metabolasm na muri rusange. Buri gihe birasabwa kugisha inama uwatanze ubuzima ku nama yihariye yerekeranye no kwiyongera no kuganira kubibazo byihariye byubuzima cyangwa ibihe.
