Stephania Gukuramo ifu ya Cepharanthine
Ifu ya Stephania Ikuramo ifu ya Cepharanthine ni ibintu biva mu birayi byikimera Stephania cephalantha Hayata (Stephania japonica （Thunb.） Miers) cyangwa Stephania epigaea Lo / Stephania yunnanensis HSLo. Cepharanthine nigicuruzwa gisanzwe gitandukanijwe niki kimera kandi cyakorewe ubushakashatsi butandukanye bitewe nubushobozi bwa farumasi. Byagaragaye ko byerekana ibikorwa birwanya SARS-CoV-2, byerekana akamaro ko guhashya ikwirakwizwa rya virusi. Byongeye kandi, Cepharanthine yerekanye ubushobozi bwo guhindura P-glycoproteine (P-gp) igereranya na multidrug irwanya selile zimwe na zimwe kandi ikongerera imbaraga imiti igabanya ubukana bwa moderi yubushakashatsi. Byongeye kandi, byagaragaye ko bifite ingaruka zibuza umwijima cytochrome P450 enzymes CYP3A4, CYP2E1, na CYP2C9, kandi ifitanye isano na antitumor, anti-inflammatory, na antinociceptive.
Muri make, Ifu ya Stephania ikuramo ifu ya Cepharanthine nuburyo bwifu yibicuruzwa bisanzwe Cepharanthine ikomoka ku gihingwa cya Stephania cephalantha, cyerekanye ubushobozi mubikorwa bitandukanye bya farumasi.
| Ibicuruzwa | Cepharanthine |
| URUBANZA | 481-49-2 |
| Suzuma | 80% ~ 99% |
| Kugaragara | Ifu yera |
| Gupakira | 1KG / Umufuka wuzuye |
| Ingingo | Ibisobanuro |
| Kugaragara | ifu yera yera, impumuro itabogamye, hygroscopique cyane |
| Kumenyekanisha | TLC: Igisubizo gisanzwe hamwe nigisubizo cyibisubizo ahantu hamwe, RF |
| Suzuma (Ishingiro ryumye) | 98.0% - 102.0% |
| Ibyiza byihariye | -2.4 ° ~ -2.8 ° |
| PH | 4.5 ~ 7.0 |
| Ibyuma Biremereye (Nka Pb) | ≤10ppm |
| As | ≤1ppm |
| Pb | ≤0.5ppm |
| Cd | ≤1ppm |
| Hg | ≤0.1ppm |
| Ibintu bifitanye isano | Ikibanza ntabwo kinini kuruta igisubizo gisanzwe |
| Ibisigisigi | <0.5% |
| Ibirimo Amazi | <2% |
Ifumbire ya Stephania Ifu ya Cepharanthine nigicuruzwa gisanzwe gikomoka ku gihingwa Stephania cephalantha Hayata. Byagaragaye ko bifite imiti myinshi ya farumasi, harimo:
1. Ibikorwa byo kurwanya SARS-CoV-2
2. Ingaruka zo gukumira ikwirakwizwa rya virusi
3. Guhindura P-glycoprotein-yunganirwa na multidrug irwanya
4. Kongera imbaraga zo kumva imiti igabanya ubukana
5. Ingaruka zibuza umwijima cytochrome P450 enzymes CYP3A4, CYP2E1, na CYP2C9
6. Antitumor, anti-inflammatory, na antinociceptive ingaruka
Biosynthesis ya cepharanthine muri Stephania itangirana no kwegeranya dopamine na 4-hydroxyphenylacetaldehyde (4-HPAA, 5) binyuze muri synthase ya Norcoclaurine (NCS), itanga Norcoclaurine.
Cepharanthine irashobora gushonga mumashanyarazi nka Ethanol, DMSO, na dimethyl formamide (DMF). Ubushobozi bwa cepharanthine muri iyi mashanyarazi ni hafi 2, 5, na 10 mg / ml. Cepharanthine irashonga cyane mumazi yo mumazi.
Inganda zisaba ifu ya Stephania ikuramo ifu ya Cepharanthine irimo Pharmaceutical, Nutraceutical, Biotechnology, na Medicine Herbal, ibyifuzo nyamukuru nibi bikurikira:
Ibishobora gukoreshwa mubuvuzi bwa virusi
Birashoboka nkibishobora kuvura kanseri
Ibishobora gukoreshwa mukuvura anti-inflammatory
Birashoboka nkumuti udasanzwe
Izi porogaramu zigaragaza uburyo butandukanye bwo gukoresha ifu ya Stephania ikuramo ifu ya Cepharanthine muburyo butandukanye bwo kuvura.
Gupakira na serivisi
Gupakira
* Igihe cyo Gutanga: Hafi y'iminsi 3-5 y'akazi nyuma yo kwishyura.
* Ipaki: Mu ngoma ya fibre ifite imifuka ibiri ya plastike imbere.
* Uburemere bwuzuye: 25kgs / ingoma, Uburemere rusange: 28kgs / Ingoma
* Ingano yingoma & Umubumbe: ID42cm × H52cm, 0.08 m³ / Ingoma
* Ububiko: Ubitswe ahantu humye kandi hakonje, irinde urumuri rukomeye nubushyuhe.
* Ubuzima bwa Shelf: Imyaka ibiri iyo ibitswe neza.
Kohereza
* DHL Express, FEDEX, na EMS kumubare uri munsi ya 50KG, mubisanzwe bita serivisi ya DDU.
* Kohereza inyanja kurenza kg 500; no kohereza mu kirere birahari kuri kg 50 hejuru.
* Kubicuruzwa bifite agaciro kanini, nyamuneka hitamo kohereza ikirere hamwe na DHL Express kubwumutekano.
* Nyamuneka wemeze niba ushobora gukora ibicuruzwa mugihe ibicuruzwa bigeze kuri gasutamo mbere yo gutanga itegeko. Ku baguzi baturutse muri Mexico, Turukiya, Ubutaliyani, Rumaniya, Uburusiya, n'utundi turere twa kure.
Uburyo bwo Kwishura no Gutanga
Express
Munsi ya 100kg, Iminsi 3-5
Serivisi ku muryango byoroshye gufata ibicuruzwa
Ku nyanja
Kurenga 300 kg, Hafi Iminsi 30
Icyambu kugeza ku cyambu serivisi yumwuga yemewe arakenewe
Na Air
100kg-1000kg, Iminsi 5-7
Ikibuga cyindege cya serivise yikibuga cyumwuga gikenewe
Ibisobanuro birambuye ku musaruro (Imbonerahamwe yerekana)
1. Gushakisha no Gusarura
2. Gukuramo
3. Kwibanda no kwezwa
4. Kuma
5. Ibipimo ngenderwaho
6. Kugenzura ubuziranenge
7. Gupakira 8. Gukwirakwiza
Icyemezo
It byemejwe na ISO, HALAL, na KOSHER ibyemezo.
