Lycorine Hydrochloride
Lycorine Hydrochloride niwe cyera gutaba ifu ya lycorine ya AlkaloIID, iboneka mubimera bya Lycoris Rariata (l'we.), Kandi ni uw'umuryango wa Imaridaceae. Lycorine Hydrochloride ifite ingaruka zinyuranye zidasanzwe, zirimo kurwanya ibibyimba, kurwanya kanseri, anti-virusi, kurwanya antilasizi, na malariya. Birashonje mumazi, Dmso, na Ethanol. Imiterere yayo ya chimique irangwa ningingo zigoye zifite uburyohe hamwe nitsinda ryimikorere myinshi, harimo hydroxyl na amino amatsinda, bigira uruhare mubikorwa byayo.
| Izina ry'ibicuruzwa | Lycorine Hydrochloride CAS: 2188-68-3 | ||
| Inkomoko y'ibimera | Lycoris | ||
| Imiterere | Ububiko hamwe na kashe yubushyuhe bwicyumba | Raporo itariki | 202.08.24 |
| Ikintu | Bisanzwe | Ibisubizo |
| Ubuziranenge(Hplc) | Lycorine Hydrochloride≥98% | 99.7% |
| Isura | Ifu yera | Guhuza |
| Kuranga umubiriics | ||
| Ibice-ingano | NLT100% 80Mesh | Guhuza |
| Gutakaza Kuma | ≤1.0% | 1.8% |
| Biremereye ibyuma | ||
| Ibyuma byose | ≤10.0ppm | Guhuza |
| Kuyobora | ≤2.0ppm | Guhuza |
| Mercure | ≤1.0ppm | Guhuza |
| Cadmium | ≤0.5ppm | Guhuza |
| Microorganism | ||
| Umubare wa bagiteri | ≤1000cfu / g | Guhuza |
| Umusemburo | ≤100CFU / G. | Guhuza |
| Escherichia Coli | Ntabwo birimo | Ntibimenyekana |
| Salmonella | Ntabwo birimo | Ntibimenyekana |
| Staphylococcus | Ntabwo birimo | Ntibimenyekana |
| UMWANZURO | Bujuje ibisabwa | |
Ibiranga:
(1) Isuku yo hejuru:Ibicuruzwa byacu byatunganijwe neza kugirango habeho ubuziranenge bwerure, aribwo bungenzi mubyiza n'umutekano muburyo butandukanye.
(2) Ibintu bidateganya:Yerekanye ingaruka zikomeye zidateganijwe ku bwoko butandukanye bwa kanseri, haba muri vitro no muri Viro, binyuze muri Vivo, binyuze muri Vivo, binyuze muri vivo, gukurura apoptosis, kandi bikabuza angiogesisi.
(3) ibikorwa byinshi:Bycorine Hydrochloride yizera ko ikorana n'intego nyinshi za molekile, zitanga umusaruro mugari urwanya kanseri.
(4) Uburozi buke:Iragaragaza uburozi buke kuri selile zisanzwe, nikintu cyingenzi mugukoresha nkumukozi wa Therapeutic.
(5) Umwirondoro wa Farumasitotic:Ibicuruzwa byibazwe kuri farumasique yayo, kwerekana ibyihuta kandi bikuraho byihuse kuva muri plasma, ari ngombwa mugutegura no kuvura.
(6) Ingaruka za Synorgistic:Lycorine Hydrochloride yerekanwe ingaruka zongerewe mugihe ikoreshwa muguhuza nibindi biyobyabwenge, bishobora kuba ingirakamaro mugutsinda ibiyobyabwenge no kunoza umusaruro wo kuvura ibiyobyabwenge.
(7) Gushyigikirwa -Ibicuruzwa bishyigikiwe nubushakashatsi bwimbitse, butanga urufatiro rukomeye kugirango rukoreshe mu iterambere rya farumasi hamwe nibisabwa.
(8) Ubwishingizi bwiza:Ingamba zidasanzwe zo kugenzura zirahari hose kugirango zibeho guhuza kandi kwizerwa kubicuruzwa.
(9) Porogaramu zitandukanye:Birakwiriye gukoreshwa mubushakashatsi no guteza imbere ibyifuzo bya farumasi, harimo no kuvumbura ibiyobyabwenge no guteza imbere kanseri.
(10) kubahiriza:Yakozwe nyuma ya GMP kugirango umutekano wigicuruzwa nibikorwa.
(1) Inganda za farumasi:Lycorine Hydrochloride ikoreshwa mugutezimbere imiti irwanya kurwanya no kurwanya.
(2) Inganda zibinyabuzima:Irakoreshwa mubushakashatsi no guteza imbere abakozi bashya bashya hamwe nibiyobyabwenge.
(3) Ubushakashatsi bwibicuruzwa bisanzwe:Lycorine Hydrochloride yizwe ku nyungu zubuzima nubuvuzi.
(4) Inganda zimiti:Irashobora gukoreshwa nkimiti yo hagati muri synthesis yibindi bigo.
(5) Inganda zubuhinzi:Lycorine Hydrochloride iperereza iperereza kubushobozi bwayo nkimiti yica udukoko hamwe no gukura gutera.
Inzira yo gukuramo Lycorine ya Lycorine ya hycorine yubusanzwe ikubiyemo intambwe zingenzi zikurikira kugirango umuntu arekure kandi anoze igipimo cyo gukira:
(1) Guhitamo ibikoresho bya Raw no Kwitegura:Hitamo AmariDiDidaceae Ibikoresho bitera Ibikoresho bibisi, nka Amaryllis, hanyuma ukarabe, byumye kandi ushishikarire kwemeza ubuziranenge bwibikoresho fatizo bikashyirwaho.
(2)Comzyite Enzyme Pretreatment:Koresha enzymes igoye (nka selile na pectinase) kugirango uhindure ibikoresho fatizo bimenetse kugirango utandure inkuta za selile no kunoza imikorere yakurikiyeho.
(3)Dilute Hydrochloric Acide:Kuvanga ibikoresho fatizo byateguwe hamwe na hydrochloric igisubizo cyo gukuramo lycorine. Gukoresha aside hydrochloric bifasha kongera igisubizo cya lycorine, bityo bigatuma kuzamura imikorere.
(4)Ultrasonic-afasha:Gukoresha ikoranabuhanga rikururwa-bivuga ko ikoranabuhanga rishobora kwihutisha inzira yo gusebanya ya Lycorine muri soteve no kunoza imikorere yo gutwika no kweza.
(5)Gukuramo chloroform:Gukuramo bikorwa hamwe na chloroform nka chloroform, kandi lycoroform, kandi lycorine yimuriwe mu cyiciro giteganijwe mu cyiciro kama kugirango areshya neza.
(6)Gukira neza:Nyuma yo gukuramo inzira, igisubizo cyagaruwe binyuze mu guhumeka cyangwa gutandukana kugirango ugabanye ibyo kurya no guteza imbere ubukungu.
(7)Gusukura no Kuma:Binyuze mu kwezwa no kumuma intambwe zumye, ifu ya hycorine ya lycorine ifata.
Muburyo bwose bwo gukuramo, kugenzura guhitamo gukemurwa, imiterere yo gukuramo (nka PH agaciro, ubushyuhe, nigihe cyo kwezwa Gukoresha ibikoresho bigezweho no kweza ibikoresho bya Ultrasonic nibikorwa byinshi byamazi ya chromatografi (HPLC), nabyo bifasha kunoza imikorere no gutanga umusaruro.
Ububiko: Gumana ahantu hakonje, byumye, kandi usukuye, urinde umucyo kandi utaziguye.
Paki nyinshi: 25Kg / ingoma.
Kugeza igihe: Iminsi 7 nyuma yo gutumiza kwawe.
Ubuzima bwa Shelf: imyaka 2.
Ijambo: Ibisobanuro byateganijwe nabyo birashobora kugerwaho.
Express
Munsi ya 100kg, 3-5 iminsi
Umuryango wa serivisi yumuryango byoroshye gufata ibicuruzwa
Inyanja
Hejuru300KG, hafi iminsi 30
Icyambu cya serivisi ya Port wabigize umwuga Broker birakenewe
N'umwuka
100kg-1000kg, 5-7 iminsi
Ikibuga cy'indege cya serivisi yikibuga cya serivisi Umunyabwenge Birakenewe
Organic Organic yabonye USDA na EU kama, BRC, ISO, Halal, Kosher, na Serivisi za Haccp.
Lycorine ni alkaloid isanzwe ishobora kuboneka mubiti byinshi, cyane cyane mumuryango wa amarshidaceae. Dore ibimera bimwe bizwi kugirango birimo Lycorine:
Lycoris Radiata.
Leucojum Aestivum(Impeshyi y'urubura), izwi kandi ko irimo lycorine.
Ungernia SewerttowiiEse ikindi gihingwa kiva mu muryango wa amaryllidaceae wagejwe no kubamo Licorine.
HIPPEASTRUM HYRBID (POLATER MOLY)nibindi bifitanye isano nibirylidaceae bizwi inkomoko ya lycorine.
Ibi bimera bikwirakwizwa mu turere dushyuha kandi dushyuha ku isi kandi dufite amateka maremare yo gukoresha mubuvuzi gakondo. Kuba Lycorine muri ibi bimera byabaye ikibazo cyubushakashatsi kubera ibintu byayo bishobora gukoreshwa bya farmacologiya, harimo ingaruka zikomeye zidasanzwe nkuko byerekanwe muburyo butandukanye.
Lycorine ni alkaloide karemano ifite ingaruka nini cyane yingaruka za farumasi, harimo no gukoresha ibishobora gukoreshwa muri kanseri. Mugihe yerekanye ingaruka zizere mubyigisho bitandukanye, hari ingaruka zimwe na zimwe zavuzwe hamwe nibitekerezo bifitanye isano no gukoresha:
Uburozi buke: Lycorine hamwe na hycorine umunyu wa hydrololoride muri rusange byerekana uburozi buke, buranga ibintu byiza kubisaba amavuriro. Yarerekanwe ko ifite ingaruka mbi ku ngaruka mbi ku tugari dusanzwe z'abantu n'imbeba zizima, utanga urwego runaka rwo guhitamo kanseri hejuru y'imirongo isanzwe.
Ingaruka zidasanzwe: Isesera yinzoga no kuruka byagaragaye nyuma yo gutwarwa no gukabya hycorine ya lycorine ya hycorloloride, ubusanzwe igandukamo amasaha 2,5 atabangamira umutekano wa biokimike cyangwa abahendutse.
Nta guhuza moteri yangiritse: Ubushakashatsi bwerekanye ko dosiye ya Lycorine idashobora kugira ingaruka ku bufatanye bwa rotarodi, byerekana ko itageragejwe na sisitemu yo hagati (CNS) ijyanye no kugenzura moteri.
Ingaruka ku gikorwa cya Lokomotoous: Ku gipimo cya 30 mg / kg, Lycorine yagaragaye ko yangijwe na Locomotor ibikorwa bya LokoMotor mu mibiri, nk'uko bigaragazwa no kugabanuka mu myitwarire no kwiyongera.
Imyitwarire rusange n'imibereho myiza: igipimo cya 10 mg / kg ya lycorine ntabwo bibangamira imyitwarire rusange n'imibereho myiza yimbeba, vuga ko ibi bishobora kuba dose nziza kubisuzuma byatanzwe.
Nta ngaruka mbi zikaze kuburemere bwumubiri cyangwa imiterere yubuzima: Ubuyobozi bwa Lycorine na Lycorine Hydroloride ntabwo byateye imbaraga zubuzima bugaragara cyangwa ubuzima bwiza bwimbeba.
Ni ngombwa kumenya ko mugihe Lycorine yerekanye ubushobozi mubiperereza ryibanze, isuzumabumenyi ndende riracyabura. Ubushakashatsi burakenewe kugirango bumve neza umwirondoro wacyo wumutekano, cyane cyane gukoresha igihe kirekire no mubuvuzi. Ingaruka z'umutekano n'umutekano wa Lycorine birashobora gutandukana bitewe na dosage, uburyo bwo kuyobora, no kuranga umuntu ku giti cye. Buri gihe ujye ugisha inama inzobere mubuzima mbere yo gusuzuma ikoreshwa ryinyongera cyangwa kuvura.
