Lycorine Hydrochloride

Synonyme:Lycorine chloride; Lycorine HCl; Lycorine (hydrochloride)
MOQ:10G
URUBANZA OYA.:2188-68-3
Isuku:NLT 98%
Kugaragara:Ifu yera
Ingingo yo gushonga:206ºC
Ingingo yo guteka:385.4 ± 42.0ºC
Ubucucike:1.03 ± 0.1g / cm3
Gukemura:Buhoro buhoro muri 95% inzoga, ntabwo ari mumazi, ntabwo muri chloroform
Ububiko:Ihagaze neza, ibike kuri + 4 ° C, ahantu hijimye.


Ibicuruzwa birambuye

Ibicuruzwa

Kumenyekanisha ibicuruzwa

Lycorine hydrochloride ni ifu yera kandi yera yera ikomoka kuri alkaloide lycorine, iboneka mu bimera bya Lycoris radiata (L'Her.), Kandi ikomoka mu muryango wa Amaryllidaceae. Hydrochloride ya Lycorine igira ingaruka zitandukanye za farumasi, harimo kurwanya ibibyimba, kurwanya kanseri, kurwanya HCV, kurwanya inflammatory, anti-bagiteri, anti-virusi, anti-angiogenez, hamwe na malariya. Irashobora gushonga mumazi, DMSO, na Ethanol. Imiterere yimiti irangwa nuburyo bugoye bwa steroidal hamwe nuburyohe bukaze hamwe nitsinda ryinshi rikora, harimo hydroxyl na amino amatsinda, bigira uruhare mubikorwa byibinyabuzima.

Ibisobanuro

Izina ryibicuruzwa Lycorine hydrochloride CAS: 2188-68-3
Inkomoko y'Ibimera Lycoris
Imiterere y'ububiko Bika hamwe na kashe mubushyuhe bwicyumba Itariki yo gutanga raporo 2024.08.24

 

Ingingo Bisanzwe Igisubizo
IsukuHPLC Lycorine hydrochloride≥98% 99.7%
Kugaragara Ifu yera Guhuza
Ibiranga umubiriics    
Ingano-nini NLT100% 80Mesh Guhuza
Gutakaza kumisha ≤1.0% 1.8%
Biremereye icyuma    
Ibyuma byose ≤10.0ppm Guhuza
Kuyobora ≤2.0ppm Guhuza
Mercure ≤1.0ppm Guhuza
Cadmium ≤0.5ppm Guhuza
Microorganism    
Umubare wa bagiteri 0001000cfu / g Guhuza
Umusemburo ≤100cfu / g Guhuza
Escherichia coli Ntabwo arimo Ntibimenyekana
Salmonella Ntabwo arimo Ntibimenyekana
Staphylococcus Ntabwo arimo Ntibimenyekana
Umwanzuro Yujuje ibyangombwa

Ibiranga

Ibiranga:
(1) Isuku ryinshi:Ibicuruzwa byacu bitunganijwe neza kugirango harebwe urwego rwo hejuru rwisuku, rukaba ari ingenzi kubikorwa byacyo n'umutekano mubikorwa bitandukanye.
(2) Indwara ya Anticancer:Yerekanye ingaruka zikomeye za anticancer zirwanya ubwoko butandukanye bwa kanseri, haba muri vitro ndetse no muri vivo, hakoreshejwe uburyo nko gutera ingirabuzimafatizo, gutera apoptose, no kubuza angiogenez.
(3) Igikorwa Cyinshi:Lycorine hydrochloride yizera ko ishobora guhura na molekile nyinshi, itanga uburyo bunini bwo kurwanya kanseri.
(4) Uburozi buke:Yerekana uburozi buke mu ngirabuzimafatizo zisanzwe, kikaba ari ikintu cyingenzi mu mikoreshereze yacyo nk'umuti wo kuvura.
(5) Umwirondoro wa Pharmacokinetic:Igicuruzwa cyakorewe ubushakashatsi kuri farumasi yacyo, cyerekana kwinjiza vuba no kurandura vuba muri plasma, ifite akamaro kanini mugutegura no kuvura.
(6) Ingaruka zo Guhuza:Lycorine hydrochloride yerekanye ingaruka nziza iyo ikoreshejwe ifatanije nindi miti, ishobora kugirira akamaro gutsinda ibiyobyabwenge no kunoza imiti ivura.
(7) Ubushakashatsi bushyigikiwe:Igicuruzwa gishyigikirwa nubushakashatsi bwimbitse, butanga urufatiro rukomeye rwo gukoresha mugutezimbere imiti no kuvura.
(8) Ubwishingizi bufite ireme:Ingamba zikomeye zo kugenzura ubuziranenge zirahari murwego rwo kubyara umusaruro kugirango ibicuruzwa byuzuzwe kandi byizewe.
(9) Porogaramu zitandukanye:Birakwiye gukoreshwa mubushakashatsi niterambere mugukoresha imiti, harimo kuvumbura imiti no guteza imbere imiti ya kanseri.
(10) Kubahiriza:Yakozwe ikurikiza ibipimo bya GMP kugirango umutekano wibicuruzwa bigerweho neza.

Gusaba

(1) Inganda zimiti:Lycorine hydrochloride ikoreshwa mugutezimbere imiti igabanya ubukana na anticancer.
(2) Inganda zikoresha ikoranabuhanga:Ikoreshwa mubushakashatsi no guteza imbere imiti mishya yo kuvura no gufata imiti.
(3) Ubushakashatsi bwibicuruzwa bisanzwe:Lycorine hydrochloride yizwe kubwinyungu zayo zubuzima hamwe nubuvuzi.
(4) Inganda zikora imiti:Irashobora gukoreshwa nkimiti igereranya muguhuza ibindi bintu.
(5) Inganda zubuhinzi:Hydrochloride ya Lycorine yakozweho ubushakashatsi ku bushobozi bwayo nk'imiti yica udukoko karemano kandi igenzura imikurire y'ibihingwa.

Ibisobanuro birambuye

Uburyo bwo kuvoma hydrocloride ya lycorine mubusanzwe burimo intambwe zingenzi zikurikira kugirango harebwe isuku yumuti no kuzamura igipimo cyo gukira:
(1) Guhitamo ibikoresho bito no kwitegura:Hitamo Amaryllidaceae ikwiye ibikoresho bibisi, nkibimuri bya Amaryllis, hanyuma ukarabe, byumye kandi ubijanjagura kugirango umenye neza ibikoresho fatizo hanyuma ushireho urufatiro rwo kubikuramo nyuma.
(2)Guteranya imisemburo ya enzyme:Koresha imisemburo igoye (nka selile na pectinase) kugirango witegure ibikoresho fatizo byajanjaguwe kugirango ubore urukuta rw'utugingo ngengabuzima kandi tunoze neza.
(3)Koresha hydrochloric acide:Kuvanga ibikoresho bibisi byateguwe hamwe na acide hydrochloric acide kugirango ukuremo lycorine. Gukoresha aside hydrochloric bifasha kongera imbaraga za lycorine, bityo bikazamura umusaruro.
(4)Gukuramo Ultrasonic:Gukoresha tekinoroji yo gukuramo ultrasonic irashobora kwihutisha uburyo bwo gusesa lycorine mumashanyarazi no kunoza imikorere yo gukuramo no kwera.
(5)Gukuramo Chloroform:Gukuramo bikorwa hamwe na solge organic nka chloroform, na lycorine yimurwa kuva mumazi yo mumazi ikajya mubice kama kugirango irusheho kweza uruganda.
(6)Gusubirana ibisubizo:Nyuma yo kuvoma, ibishishwa bigarurwa binyuze mu guhumeka cyangwa kuyungurura kugirango igabanye ibicuruzwa kandi bizamura ubukungu.
(7)Kweza no gukama:Binyuze mu kweza neza no gukama, haboneka ifu ya hydrocloride ya lycorine.
Muburyo bwose bwo kuvoma, kugenzura guhitamo ibisubizo, uburyo bwo kuvoma (nkagaciro ka pH, ubushyuhe, nigihe), hamwe nintambwe yo kweza nyuma nurufunguzo rwo kwemeza isuku no kuzamura igipimo cyo gukira. Gukoresha ibikoresho bigezweho byo kuvoma no kweza, nkibikurura ultrasonic hamwe na sisitemu ya chromatografiya ikora cyane (HPLC), nayo ifasha kunoza imikorere yo kuvoma nubuziranenge bwibicuruzwa.

Gupakira na serivisi

Ububiko: Bika ahantu hakonje, humye, kandi hasukuye, Kurinda ubushuhe n’umucyo utaziguye.
Igipapuro kinini: 25kg / ingoma.
Igihe cyo kuyobora: iminsi 7 nyuma yo gutumiza.
Ubuzima bwa Shelf: imyaka 2.
Icyitonderwa: Ibisobanuro byihariye nabyo birashobora kugerwaho.

gupakira

Uburyo bwo Kwishura no Gutanga

Express
Munsi ya 100kg, Iminsi 3-5
Serivisi ku muryango byoroshye gufata ibicuruzwa

Ku nyanja
Kurenga 300 kg, Hafi Iminsi 30
Icyambu kugeza ku cyambu serivisi yumwuga yemewe arakenewe

Na Air
100kg-1000kg, Iminsi 5-7
Ikibuga cyindege cya serivise yikibuga cyumwuga gikenewe

trans

Icyemezo

Bioway Organic yabonye USDA na EU organic, BRC, ISO, HALAL, KOSHER, na HACCP.

CE

Ibibazo (Ibibazo bikunze kubazwa)

Ni ibihe bimera birimo lycorine?

Lycorine ni alkaloide isanzwe iboneka mu bimera byinshi, cyane cyane mu muryango wa Amaryllidaceae. Hano hari ibihingwa bizwiho kuba birimo lycorine:
Lycoris radiata(bizwi kandi nk'igitagangurirwa gitukura lili cyangwa manjushage) nicyatsi gakondo cyimiti yubushinwa kirimo lycorine.
Leucojum aestivum(urubura rwo mu mpeshyi), bizwi kandi ko birimo lycorine.
Ungernia sewertzowiini ikindi gihingwa cyo mu muryango wa Amaryllidaceae bivugwa ko kirimo lycorine.
Imvange ya Hippeastrum (lili ya pasika)nibindi bifitanye isano na Amaryllidaceae nibimera bizwi bya lycorine.
Ibi bimera bikwirakwizwa cyane mu turere dushyuha no mu turere dushyuha kandi dufite amateka maremare yo gukoresha mu buvuzi gakondo. Kubaho kwa lycorine muri ibyo bimera byakorewe ubushakashatsi kubera imiterere y’imiti, harimo n'ingaruka zikomeye za anticancer nkuko bigaragara mu bushakashatsi butandukanye.

Ni izihe ngaruka mbi za lycorine?

Lycorine ni alkaloide isanzwe ifite ingaruka zitandukanye za farumasi, harimo no kuyikoresha mu kuvura kanseri. Mugihe yerekanye ibisubizo bitanga umusaruro mubushakashatsi butandukanye, haribintu bimwe byavuzwe ingaruka n'ingaruka zijyanye no gukoresha:
Uburozi buke: Lycorine n'umunyu wa hydrochloride muri rusange byerekana uburozi buke, ibyo bikaba ari byiza kuranga amavuriro. Byagaragaye ko bifite ingaruka nkeya ku ngirabuzimafatizo zisanzwe z’imbeba n’imbeba nzima, byerekana urwego runaka rwo guhitamo ingirabuzimafatizo za kanseri ku ngingo zisanzwe.
Ingaruka z'igihe gito: Isesemi nigihe cyo kuruka byagaragaye nyuma yo guterwa insimburangingo cyangwa imitsi yatewe na hydrochloride ya lycorine, ubusanzwe igabanuka mugihe cyamasaha 2.5 bitagize ingaruka kumutekano wibinyabuzima cyangwa hematologiya.
Nta guhuza ibinyabiziga byangiritse: Ubushakashatsi bwerekanye ko dosiye ikurikirana ya lycorine itagira ingaruka ku guhuza ibinyabiziga mu mbeba, nkuko byageragejwe na test ya rotarod, byerekana ko bidatera ingaruka mbi za sisitemu yo hagati (CNS) ingaruka zijyanye no kugenzura moteri.
Ingaruka ku gikorwa cya Lokomoteri Yikora: Ku gipimo cya 30 mg / kg, lycorine yagaragaye ko ibangamira ibikorwa bya moteri yimbeba mu mbeba, nkuko bigaragazwa no kugabanuka kwimyitwarire yo kurera no kwiyongera kwubudahangarwa.
Imyitwarire rusange n'imibereho myiza: Igipimo cya mg / kg 10 ya lycorine nticyigeze kibangamira imyitwarire rusange n'imibereho myiza yimbeba, byerekana ko iyi ishobora kuba igipimo cyiza cyo gusuzuma neza imiti ivura.
Nta ngaruka zikomeye zigira ku buremere bw'umubiri cyangwa uko ubuzima bumeze: Ubuyobozi bwa hydrocloride ya lycorine na lycorine ntabwo bwateje ingaruka zigaragara ku buremere bw'umubiri cyangwa ku buzima rusange muri rusange bwerekana imbeba zifite ibibyimba.
Ni ngombwa kumenya ko mugihe lycorine yerekanye ubushobozi mu iperereza ryibanze, isuzuma ryuburozi bwigihe kirekire riracyabura. Ubundi bushakashatsi burakenewe kugirango wumve neza imiterere yumutekano wabwo, cyane cyane kubikoresha igihe kirekire no mubuvuzi. Ingaruka n’umutekano bya lycorine birashobora gutandukana bitewe na dosiye, uburyo bwo kuyobora, nibiranga abarwayi kugiti cyabo. Buri gihe ujye ubaza inzobere mu by'ubuzima mbere yo gusuzuma ikoreshwa ry'inyongera cyangwa imiti.


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